Bryan J. Xie
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View article: Donor regulatory T-cell therapy to prevent graft-versus-host disease
Donor regulatory T-cell therapy to prevent graft-versus-host disease Open
Allogeneic hematopoietic cell transplantation is a curative therapy limited by graft-versus-host disease (GVHD). In preclinical studies and early-phase clinical studies, enrichment of donor regulatory T cells (Tregs) appears to prevent GVH…
View article: Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD
Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD Open
Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for hematological malignancies for which graft-versus-host disease (GVHD) remains a major complication. The use of donor T-regulatory cells (Tregs) to prevent GVHD a…
View article: Immunoregulatory effects of RGMb in gut inflammation
Immunoregulatory effects of RGMb in gut inflammation Open
Graft-versus-host disease (GvHD) is a major complication after allogeneic hematopoietic cell transplantation (HCT). Current strategies to prevent GvHD with immunosuppressive drugs carry significant morbidity and may affect the graft-versus…
View article: 403 Rapid and multiplexed identification of novel TCRs for TCR-T cell therapy
403 Rapid and multiplexed identification of novel TCRs for TCR-T cell therapy Open
Background T cell receptor (TCR)-based therapeutics have displayed clinical proof-of-concept, however challenges remain to robustly identify both novel targets and therapeutically active TCRs against endogenous targets. Methods Here, we ha…
View article: Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection
Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection Open
View article: Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection
Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection Open
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find…
View article: High-parametric evaluation of human invariant natural killer T cells to delineate heterogeneity in allo- and autoimmunity
High-parametric evaluation of human invariant natural killer T cells to delineate heterogeneity in allo- and autoimmunity Open
Human invariant natural killer T (iNKT) cells are a rare innate-like lymphocyte population that recognizes glycolipids presented on CD1d. Studies in mice have shown that these cells are heterogeneous and are capable of enacting diverse fun…
View article: Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients
Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients Open
BACKGROUNDIn preclinical murine and early clinical studies of hematopoietic cell transplantation, engineering of donor grafts with defined ratios of CD4+CD25+FoxP3+ Tregs to conventional T cells (Tcons) results in the prevention of graft-v…
View article: Donor-Derived Cytokine-Induced Killer Cell Infusion as Consolidation after Nonmyeloablative Allogeneic Transplantation for Myeloid Neoplasms
Donor-Derived Cytokine-Induced Killer Cell Infusion as Consolidation after Nonmyeloablative Allogeneic Transplantation for Myeloid Neoplasms Open
View article: 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition
4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition Open