Bryan L. Fahl
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View article: Significant Suppression of Multiple Sclerosis in the Mouse EAE Model Using the PrC-210 Aminothiol
Significant Suppression of Multiple Sclerosis in the Mouse EAE Model Using the PrC-210 Aminothiol Open
Multiple sclerosis (MS) is a complex disease marked by chronic neuroinflammation and reactive oxygen species (ROS) toxicity in the central nervous system (CNS). Based on this ROS-driven mechanism, we tested whether PrC-210—a new aminothiol…
View article: Significant Reduction of Radiation-Induced Death in Mice Treated with PrC-210 and G-CSF after Irradiation
Significant Reduction of Radiation-Induced Death in Mice Treated with PrC-210 and G-CSF after Irradiation Open
The search for single or combined radiation countermeasures that mitigate the development of Acute Radiation Syndrome (ARS) after radiation exposure remains a prominent goal of the U.S. government. This study was undertaken to determine wh…
View article: Significant reduction of ischemia‐reperfusion cell death in mouse myocardial infarcts using the immediate‐acting PrC‐210 ROS‐scavenger
Significant reduction of ischemia‐reperfusion cell death in mouse myocardial infarcts using the immediate‐acting PrC‐210 ROS‐scavenger Open
Managing myocardial infarction (MI) to reduce cardiac cell death relies primarily on timely reperfusion of the affected coronary site, but reperfusion itself induces cell death through a toxic, ROS‐mediated process. In this study, we deter…