Bryan Laraway
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Understanding Comorbidities in Hypermobile Ehlers-Danlos Syndrome: Could a Viral Infection Lead to a Diagnosis? Open
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be…
View article: Mondo: Integrating Disease Terminology Across Communities
Mondo: Integrating Disease Terminology Across Communities Open
Precision medicine aims to enhance diagnosis, treatment, and prognosis by integrating multimodal data at the point of care. However, challenges arise due to the vast number of diseases, differing methods of classification, and conflicting …
Why we need all the organisms: an exploration of the Monarch knowledge graph to aid mechanism discovery Open
Research done using model organisms has been fundamental to the biological understanding of human genes, diseases and phenotypes. Model organisms provide tractable systems for experiments to enhance understanding of biological mechanisms c…
Insights from an N3C RECOVER EHR-based cohort study characterizing SARS-CoV-2 reinfections and Long COVID Open
Background Although the COVID-19 pandemic has persisted for over 3 years, reinfections with SARS-CoV-2 are not well understood. We aim to characterize reinfection, understand development of Long COVID after reinfection, and compare severit…
View article: The Monarch Initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species
The Monarch Initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species Open
Bridging the gap between genetic variations, environmental determinants, and phenotypic outcomes is critical for supporting clinical diagnosis and understanding mechanisms of diseases. It requires integrating open data at a global scale. T…
View article: The Human Phenotype Ontology in 2024: phenotypes around the world
The Human Phenotype Ontology in 2024: phenotypes around the world Open
The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through seman…
View article: Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed i…
View article: Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
View article: Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Data from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed i…
View article: Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland Open
Supplementary Methods, Table 1, Figures 1-4 from Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
SARS-CoV-2 Reinfection is Preceded by Unique Biomarkers and Related to Initial Infection Timing and Severity: an N3C RECOVER EHR-Based Cohort Study Open
Although the COVID-19 pandemic has persisted for over 2 years, reinfections with SARS-CoV-2 are not well understood. We use the electronic health record (EHR)-based study cohort from the National COVID Cohort Collaborative (N3C) as part of…
Metformin is Associated with Reduced COVID-19 Severity in Patients with Prediabetes Open
Background With the continuing COVID-19 pandemic, identifying medications that improve COVID-19 outcomes is crucial. Studies suggest that use of metformin, an oral antihyperglycemic, is associated with reduced COVID-19 severity in individu…
Post-COVID Phenotypic Manifestations are Associated with New-Onset Psychiatric Disease: Findings from the NIH N3C and RECOVER Studies Open
Acute COVID-19 infection can be followed by diverse clinical manifestations referred to as Post Acute Sequelae of SARS-CoV2 Infection (PASC). Studies have shown an increased risk of being diagnosed with new-onset psychiatric disease follow…
View article: A method for comparing multiple imputation techniques: a case study on the U.S. National COVID Cohort Collaborative
A method for comparing multiple imputation techniques: a case study on the U.S. National COVID Cohort Collaborative Open
Healthcare datasets obtained from Electronic Health Records have proven to be extremely useful to assess associations between patients' predictors and outcomes of interest. However, these datasets often suffer from missing values in a high…
Generalizable Long COVID Subtypes: Findings from the NIH N3C and RECOVER Programs Open
Accurate stratification of patients with post-acute sequelae of SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, the natural history of long COVID is incompletely understood and char…
View article: Risk of new‐onset psychiatric sequelae of <scp>COVID</scp>‐19 in the early and late post‐acute phase
Risk of new‐onset psychiatric sequelae of <span>COVID</span>‐19 in the early and late post‐acute phase Open
Recent publications have documented that a proportion of COVID-19 patients develop psychiatric symptoms during or after acute infection1. We investigated this risk in the context of the National COVID Cohort Collaborative (N3C) – a central…
View article: Increased risk of psychiatric sequelae of COVID-19 is highest early in the clinical course
Increased risk of psychiatric sequelae of COVID-19 is highest early in the clinical course Open
Summary Background COVID-19 has been shown to increase the risk of adverse mental health consequences. A recent electronic health record (EHR)-based observational study showed an almost two-fold increased risk of new-onset mental illness i…
View article: The GA4GH Phenopacket schema: A computable representation of clinical data for precision medicine
The GA4GH Phenopacket schema: A computable representation of clinical data for precision medicine Open
Despite great strides in the development and wide acceptance of standards for exchanging structured information about genomic variants, there is no corresponding standard for exchanging phenotypic data, and this has impeded the sharing of …
Feeding Activated <i>Bifidobacterium infantis</i> EVC001 to Very Low Birth Weight Infants is Associated with Significant Reduction in Rates of Necrotizing Enterocolitis Open
Objectives To assess the effects of Bifidobacterium infantis EVC001 administration on the rate of necrotizing enterocolitis (NEC) in preterm infants in a single Level IV NICU. Study Design This was a retrospective observational analysis of…
The Monarch Initiative: An integrative data and analytic platform connecting phenotypes to genotypes across species Open
The principles of genetics apply across the whole tree of life: on a cellular level, we share mechanisms with species from which we diverged millions or even billions of years ago. We can exploit this common ancestry at the level of sequen…
The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species Open
The correlation of phenotypic outcomes with genetic variation and environmental factors is a core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient phenotypes may not match known diseases, candidate varia…