Bryan Lizza
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View article: Machine learning to predict vasopressin responsiveness in patients with septic shock
Machine learning to predict vasopressin responsiveness in patients with septic shock Open
Study Objectives The objective of this study was to develop and externally validate a model to predict adjunctive vasopressin response in patients with septic shock being treated with norepinephrine for bedside use in the intensive care un…
View article: Impact of Stress Ulcer Prophylaxis Discontinuation Guidance in Mechanically Ventilated, Critically Ill Patients: A Pre-Post Cohort Study
Impact of Stress Ulcer Prophylaxis Discontinuation Guidance in Mechanically Ventilated, Critically Ill Patients: A Pre-Post Cohort Study Open
Purpose: Recent data highlight unclear efficacy and potential negative sequelae of stress ulcer prophylaxis (SUP) in the intensive care unit (ICU). Minimizing SUP exposure has pertinent clinical and other implications. This study assessed …
View article: Table of Contents
Table of Contents Open
View article: New Perspectives on Antimicrobial Agents: Ceftolozane-Tazobactam
New Perspectives on Antimicrobial Agents: Ceftolozane-Tazobactam Open
Ceftolozane-tazobactam (C/T) is a new fifth-generation cephalosporin/beta-lactamase inhibitor combination approved by the Food and Drug Administration and the European Medicines Agency for treatment of complicated intraabdominal infections…
View article: The Feasibility and Validity of Objective and Patient-Reported Measurements of Cognition During Early Critical Illness Recovery
The Feasibility and Validity of Objective and Patient-Reported Measurements of Cognition During Early Critical Illness Recovery Open
View article: Circadian Gene Expression Rhythms During Critical Illness
Circadian Gene Expression Rhythms During Critical Illness Open
Objectives: Core clock genes regulate tissue-specific transcriptome oscillations that synchronize physiologic processes throughout the body, held in phase by the central circadian rhythm. The central circadian rhythm rapidly dampens with o…
View article: Factors Disrupting Melatonin Secretion Rhythms During Critical Illness
Factors Disrupting Melatonin Secretion Rhythms During Critical Illness Open
Objectives: The circadian system modulates many important physiologic processes, synchronizing tissue-specific functions throughout the body. We sought to characterize acute alterations of circadian rhythms in critically ill patients and t…
View article: Stress-Induced Behavioral Quiescence and Abnormal Rest-Activity Rhythms During Critical Illness
Stress-Induced Behavioral Quiescence and Abnormal Rest-Activity Rhythms During Critical Illness Open
Objectives: To characterize acute alterations of circadian and ultradian rest-activity rhythms in critically ill patients and their association with brain dysfunction, systemic multiple organ dysfunction, and melatonin rhythms. Design: Pro…
View article: Rapid Detection of Methicillin-Resistant Staphylococcus aureus in BAL
Rapid Detection of Methicillin-Resistant Staphylococcus aureus in BAL Open
View article: Pharmacist Education at Discharge Correlates with Reduced 30-Day Readmissions in Heart Failure Patients
Pharmacist Education at Discharge Correlates with Reduced 30-Day Readmissions in Heart Failure Patients Open
View article: Refining Prognosis for Intracerebral Hemorrhage by Early Reassessment
Refining Prognosis for Intracerebral Hemorrhage by Early Reassessment Open
Background: Prognostic assessments, which are crucial for decision-making in critical illnesses, have shown unsatisfactory reliability. We compared the accuracy of a widely used prognostic score against a model derived from c…
View article: Supplementary Material for: Refining Prognosis for Intracerebral Hemorrhage by Early Reassessment
Supplementary Material for: Refining Prognosis for Intracerebral Hemorrhage by Early Reassessment Open
Background: Prognostic assessments, which are crucial for decision-making in critical illnesses, have shown unsatisfactory reliability. We compared the accuracy of a widely used prognostic score against a model derived from c…
View article: Supplementary Material for: Refining Prognosis for Intracerebral Hemorrhage by Early Reassessment
Supplementary Material for: Refining Prognosis for Intracerebral Hemorrhage by Early Reassessment Open
Background: Prognostic assessments, which are crucial for decision-making in critical illnesses, have shown unsatisfactory reliability. We compared the accuracy of a widely used prognostic score against a model derived from c…
View article: Tree-Based Models for Predicting Mortality in Gram-Negative Bacteremia: Avoid Putting the CART before the Horse
Tree-Based Models for Predicting Mortality in Gram-Negative Bacteremia: Avoid Putting the CART before the Horse Open
Increasingly, infectious disease studies employ tree-based approaches, e.g., classification and regression tree modeling, to identify clinical thresholds. We present tree-based-model-derived thresholds along with their measures of uncertai…
View article: 23.4% Saline Decreases Brain Tissue Volume in Severe Hepatic Encephalopathy as Assessed by a Quantitative CT Marker
23.4% Saline Decreases Brain Tissue Volume in Severe Hepatic Encephalopathy as Assessed by a Quantitative CT Marker Open
Total cerebrospinal fluid and ventricular volumes increased after 23.4% hypertonic saline, consistent with a reduction in brain tissue volume. Total cerebrospinal fluid and ventricular volume change may be useful quantitative measures to a…