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View article: Machine learning in the prediction of diabetic peripheral neuropathy: a systematic review
Machine learning in the prediction of diabetic peripheral neuropathy: a systematic review Open
Objective This systematic review provides an overview of machine learning (ML) methods for predicting diabetic peripheral neuropathy (DPN). Method We searched PubMed, Embase, Cochrane Library, and Web of Science databases with the search p…
View article: Modular striatal dynamics and reciprocal inhibition orchestrate skilled action sequencing
Modular striatal dynamics and reciprocal inhibition orchestrate skilled action sequencing Open
The basal ganglia, particularly the striatum, are critical for orchestrating skilled behavioral sequences, yet the precise mechanisms underlying this process remain unclear. Using high-resolution kinematic tracking and neural recordings in…
View article: Effectiveness of oral <i>vs</i> intravenous acetaminophen on pain management following total joint arthroplasty: A systematic review and meta-analysis
Effectiveness of oral <i>vs</i> intravenous acetaminophen on pain management following total joint arthroplasty: A systematic review and meta-analysis Open
BACKGROUND In the management of postoperative pain following total joint arthroplasty (TJA), the use of nonsteroidal anti-inflammatory drugs, including acetaminophen, plays a key role in alleviating pain. However, the comparison between in…
View article: A2A-Positive Neurons in the Nucleus Accumbens Core Regulate Effort Exertion
A2A-Positive Neurons in the Nucleus Accumbens Core Regulate Effort Exertion Open
Previous work has implicated the nucleus accumbens (NAc) in the regulation of effort, defined as the amount of work an animal is willing to perform for a given reward, but little is known about the specific contributions of neuronal popula…
View article: GABAergic neurons in the ventral tegmental area represent and regulate force vectors
GABAergic neurons in the ventral tegmental area represent and regulate force vectors Open
The ventral tegmental area (VTA), a midbrain region associated with motivated behaviors, contains mostly dopaminergic (DA) neurons and GABAergic (GABA) neurons. Previous work has suggested that VTA GABA neurons provide a reward prediction …
View article: GABAergic Neurons from the Ventral Tegmental Area Represent and Regulate Force Vectors
GABAergic Neurons from the Ventral Tegmental Area Represent and Regulate Force Vectors Open
The ventral tegmental area (VTA), a midbrain region associated with motivated behaviors, consists predominantly of dopaminergic (DA) neurons and GABAergic (GABA) neurons. Previous work has suggested that VTA GABA neurons provide a reward p…
View article: A2A-positive neurons in the nucleus accumbens core regulate effort exertion
A2A-positive neurons in the nucleus accumbens core regulate effort exertion Open
Previous work has implicated the nucleus accumbens (NAc) in the regulation of effort, defined as the amount of work an animal is willing to perform for a given reward, but little is known about the specific contributions of neuronal popula…
View article: GABAergic neurons from the ventral tegmental area represent and regulate force vectors
GABAergic neurons from the ventral tegmental area represent and regulate force vectors Open
Summary The ventral tegmental area (VTA), a midbrain region associated with motivated behaviors, consists predominantly of dopaminergic (DA) neurons and GABAergic (GABA) neurons. Previous work has suggested that VTA GABA neurons provide a …
View article: Norepinephrine versus phenylephrine for managing maternal hypotension during cesarean delivery under spinal anesthesia: a meta-analysis of maternal and neonatal outcomes
Norepinephrine versus phenylephrine for managing maternal hypotension during cesarean delivery under spinal anesthesia: a meta-analysis of maternal and neonatal outcomes Open
Norepinephrine or phenylephrine administration to prevent and treat hypotension during spinal anesthesia for cesarean section has been a significant topic of discussion. This meta-analysis aimed to update existing evidence and provide furt…
View article: Mechanical analysis of the femoral neck dynamic intersection system with different nail angles and clinical applications
Mechanical analysis of the femoral neck dynamic intersection system with different nail angles and clinical applications Open
Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMT…
View article: Effectiveness of Patient-Controlled Intravenous Analgesia (PCIA) with Sufentanil Background Infusion for Post-Cesarean Analgesia: A Randomized Controlled Trial
Effectiveness of Patient-Controlled Intravenous Analgesia (PCIA) with Sufentanil Background Infusion for Post-Cesarean Analgesia: A Randomized Controlled Trial Open
Background infusion increased the total consumption of sufentanil within 36 h after cesarean section. Although it did not reduce uterine contraction pain and wound pain at 36 h, it significantly reduced the pain at 6, 12, and 24 h after ce…
View article: Circulating Osteocalcin is Associated with Time in range and other Metrics Assessed by Continuous Glucose Monitoring in Type 2 Diabetes
Circulating Osteocalcin is Associated with Time in range and other Metrics Assessed by Continuous Glucose Monitoring in Type 2 Diabetes Open
Background: Osteocalcin is a sort of protein secreted by osteoblast exclusively,and new observations have verified that glucose balance can be modulated by it in some ways. TIR has attracted more and more attention as an emerging blood glu…
View article: CD8-positive Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract: Case Report and Literature Review.
CD8-positive Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract: Case Report and Literature Review. Open
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPD-GI), a primary tumor forming in the GI tract, represents a rarely diagnosed clonal T-cell disease with a protracted clinical course. This report presents a 4…
View article: Time in Range, Especially Overnight Time in Range, Is Associated With Sudomotor Dysfunction in Patients With Type 1 Diabetes
Time in Range, Especially Overnight Time in Range, Is Associated With Sudomotor Dysfunction in Patients With Type 1 Diabetes Open
Background: To research the relationship between time in range (TIR) including overnight TIR and sudomotor function detected by SUDOSCAN in type 1 diabetes (T1D).Methods: 95 patients with T1D were enrolled. TIR of 3.9-10.0 mmol/L was evalu…
View article: NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission Open
Significance The large cytosolic GTPase dynamin-related protein 1 (Drp1) self-assembles around mitochondria to mechanoenzymatically constrict and divide the double-membrane–bound organelle. Although Drp1 recruitment to the mitochondrial su…
View article: Apoptosis detection: a purpose-dependent approach selection
Apoptosis detection: a purpose-dependent approach selection Open
Apoptosis is closely associated with many diseases. Detection of apoptosis can be achieved by morphology, biochemistry, molecular biology, immunology, and other techniques. However, as technologies are increasingly used for the detection o…
View article: Retraction: Efficacy and safety of tripterygium glycosides for active moderate to severe Graves’ ophthalmopathy: a randomised, observer-masked, single-centre trial
Retraction: Efficacy and safety of tripterygium glycosides for active moderate to severe Graves’ ophthalmopathy: a randomised, observer-masked, single-centre trial Open
"Retraction: Efficacy and safety of tripterygium glycosides for active moderate to severe Graves’ ophthalmopathy: a randomised, observer-masked, single-centre trial" published on Apr 2021 by Bioscientifica Ltd.
View article: Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission
Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission Open
The self-assembling, mechanoenzymatic dynamin superfamily GTPase, dynamin-related protein 1 (Drp1), catalyzes mitochondrial and peroxisomal fission. Distinct intrinsically disordered regions (IDRs) in Drp1 substitute for the canonical plec…
View article: A systematic review and meta-analysis into the effect of lateral wedge arch support insoles for reducing knee joint load in patients with medial knee osteoarthritis
A systematic review and meta-analysis into the effect of lateral wedge arch support insoles for reducing knee joint load in patients with medial knee osteoarthritis Open
Although meta-analysis outcomes of all studies indicated statistically significant associations between LWAS and reductions of the first peak EKAM, second peak EKAM and KAAI in people with medial knee OA while walking, different results ex…
View article: Effects of Intracranial Pressure Monitoring on Mortality in Patients with Severe Traumatic Brain Injury: A Meta-Analysis
Effects of Intracranial Pressure Monitoring on Mortality in Patients with Severe Traumatic Brain Injury: A Meta-Analysis Open
Superior survival was observed in severe TBI patients with ICP monitoring since the third edition of "Guidelines for the Management of Severe Traumatic Brain Injury," which included "Indications for intracranial pressure monitoring," was p…
View article: Detection of TORCH pathogens in children with congenital cataracts
Detection of TORCH pathogens in children with congenital cataracts Open
The aim of the present study was to investigate the correlation between infection rates with TORCH pathogens including toxoplasma, rubella virus, cytomegalovirus, and herpes simplex virus (HSV) I and II and congenital cataracts. In total, …
View article: The destructive effect of botulinum neurotoxins on the SNARE protein: SNAP-25 and synaptic membrane fusion
The destructive effect of botulinum neurotoxins on the SNARE protein: SNAP-25 and synaptic membrane fusion Open
Synaptic exocytosis requires the assembly of syntaxin 1A and SNAP-25 on the plasma membrane and synaptobrevin 2 (VAMP2) on the vesicular membrane to bridge the two opposite membranes. It is believed that the three SNARE proteins assemble i…