Bryan M. Krause
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View article: Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants
Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants Open
View article: Wearable peripheral nerve stimulator reduces essential tremor symptoms through targeted brain modulation
Wearable peripheral nerve stimulator reduces essential tremor symptoms through targeted brain modulation Open
In sum, TAPS likely reduces tremor in ET by modulating the VIM and connected nodes in the cerebello-thalamo-cortical pathway.
View article: Dexmedetomidine produces more sleep-like brain activity compared to propofol
Dexmedetomidine produces more sleep-like brain activity compared to propofol Open
Introduction Dexmedetomidine is a selective α 2 -adrenergic agonist used as an anesthesia adjunct to produce a state of sleep-like sedation. However, how brain activity compares quantitatively during dexmedetomidine anesthesia to that duri…
View article: Human forebrain neural synchronization and entrainment to breathing during wakefulness, sleep, and external mechanical ventilation
Human forebrain neural synchronization and entrainment to breathing during wakefulness, sleep, and external mechanical ventilation Open
View article: Changes in cortical delta power during chronic invasive epilepsy monitoring
Changes in cortical delta power during chronic invasive epilepsy monitoring Open
Objective Cortical delta band (1–4 Hz) activity is considered a biomarker for states of altered consciousness, with increased delta power observed during anesthesia, sleep, coma, and delirium. The current study sought to characterize delta…
View article: Transcutaneous afferent patterned stimulation reduces essential tremor symptoms through modulation of neural activity in the ventral intermediate nucleus of the thalamus
Transcutaneous afferent patterned stimulation reduces essential tremor symptoms through modulation of neural activity in the ventral intermediate nucleus of the thalamus Open
Essential tremor (ET), the most common movement disorder in adults, presents with involuntary shaking of the arms during postural hold and kinetic tasks linked to dysfunction in the cerebello-thalamo-cortical (CTC) network. Recently, trans…
View article: Diabetes Mellitus Is Not a Risk Factor for Difficult Intubation Among Critically Ill Adults: A Secondary Analysis of Multicenter Trials
Diabetes Mellitus Is Not a Risk Factor for Difficult Intubation Among Critically Ill Adults: A Secondary Analysis of Multicenter Trials Open
OBJECTIVES: Diabetes mellitus has been associated with greater difficulty of tracheal intubation in the operating room. This relationship has not been examined for tracheal intubation of critically ill adults. We examined whether diabetes …
View article: Co-administration of midazolam and psilocybin: differential effects on subjective quality versus memory of the psychedelic experience
Co-administration of midazolam and psilocybin: differential effects on subjective quality versus memory of the psychedelic experience Open
View article: Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank
Association between surgical admissions, cognition, and neurodegeneration in older people: a population-based study from the UK Biobank Open
View article: Co-administration of midazolam and psilocybin: Differential effects on subjective quality versus memory of the psychedelic experience
Co-administration of midazolam and psilocybin: Differential effects on subjective quality versus memory of the psychedelic experience Open
Aspects of the acute experience induced by the serotonergic psychedelic psilocybin predict symptomatic relief in multiple psychiatric disorders and improved well-being in healthy participants, but whether these therapeutic effects are imme…
View article: Divergent Effects of Ketamine and the Serotoninergic Psychedelic 2,5-Dimethoxy-4-Iodoamphetamine on Hippocampal Plasticity and Metaplasticity
Divergent Effects of Ketamine and the Serotoninergic Psychedelic 2,5-Dimethoxy-4-Iodoamphetamine on Hippocampal Plasticity and Metaplasticity Open
Introduction: Serotonergic psychedelics and ketamine produce rapid and long-lasting symptomatic relief in multiple psychiatric disorders. Evidence suggests that despite having distinct molecular targets, both drugs may exert therapeutic be…
View article: Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology
Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology Open
Understanding central auditory processing critically depends on defining underlying auditory cortical networks and their relationship to the rest of the brain. We addressed these questions using resting state functional connectivity derive…
View article: Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep
Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep Open
Theories of consciousness suggest that brain mechanisms underlying transitions into and out of unconsciousness are conserved no matter the context or precipitating conditions. We compared signatures of these mechanisms using intracranial e…
View article: High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors
High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors Open
View article: High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors
High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors Open
Data to reproduce figures in submitted manuscript "High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors" https://www.biorxiv.org/content/10.1101/2022.11.18.516669v1
View article: High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors
High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors Open
Data to reproduce figures in submitted manuscript "High-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors" https://www.biorxiv.org/content/10.1101/2022.11.18.516669v1
View article: Control of contextual memory through interneuronal α5-GABAA receptors
Control of contextual memory through interneuronal α5-GABAA receptors Open
γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABAARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal neuron dendrites have long …
View article: Improved high-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors
Improved high-dimensional multivariate autoregressive model estimation of human electrophysiological data using fMRI priors Open
Multivariate autoregressive (MVAR) model estimation enables assessment of causal interactions in brain networks. However, accurately estimating MVAR models for high-dimensional electrophysiological recordings is challenging due to the exte…
View article: Consciousness is indexed by analogous cortical reorganization during sleep and anesthesia
Consciousness is indexed by analogous cortical reorganization during sleep and anesthesia Open
Although sleep and anesthesia are predicted to share common neural signatures of transitions into and out of unconsciousness, supportive evidence has been elusive. We identified these signatures using intracranial electroencephalography in…
View article: Scheduled methadone reduces overall opioid requirements after pediatric posterior spinal fusion: A single center retrospective case series
Scheduled methadone reduces overall opioid requirements after pediatric posterior spinal fusion: A single center retrospective case series Open
Background Posterior spinal fusion to correct adolescent idiopathic scoliosis is associated with significant postoperative pain. Different modalities have been reported as part of a multimodal analgesic plan. Intravenous methadone acts as …
View article: Connected consciousness after tracheal intubation in young adults: an international multicentre cohort study
Connected consciousness after tracheal intubation in young adults: an international multicentre cohort study Open
View article: Impact of perioperative inflammation on days alive and at home after surgery
Impact of perioperative inflammation on days alive and at home after surgery Open
View article: Multivariate autoregressive model estimation for high-dimensional intracranial electrophysiological data
Multivariate autoregressive model estimation for high-dimensional intracranial electrophysiological data Open
View article: Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology
Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology Open
Critical details remain unresolved about the organization of the human auditory cortical hierarchy and its relationship to higher order brain networks. We investigated this organization using diffusion map embedding (DME) applied to restin…
View article: Control of contextual memory through interneuronal α5-GABA<sub>A</sub>receptors
Control of contextual memory through interneuronal α5-GABA<sub>A</sub>receptors Open
γ-aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABA A Rs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal neuron dendrites have lon…
View article: Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology
Functional geometry of auditory cortical resting state networks derived from intracranial electrophysiology Open
Understanding central auditory processing critically depends on defining underlying auditory cortical networks and their relationship to the rest of the brain. We addressed these questions using resting state functional connectivity derive…
View article: Topological Classification in a Wasserstein Distance Based Vector Space
Topological Classification in a Wasserstein Distance Based Vector Space Open
Classification of large and dense networks based on topology is very difficult due to the computational challenges of extracting meaningful topological features from real-world networks. In this paper we present a computationally tractable…
View article: Association of Major Surgical Admissions With Quality of Life
Association of Major Surgical Admissions With Quality of Life Open
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View article: Multivariate autoregressive model estimation for high dimensional intracranial electrophysiological data
Multivariate autoregressive model estimation for high dimensional intracranial electrophysiological data Open
Fundamental to elucidating the functional organization of the brain is the assessment of causal interactions between different brain regions. Multivariate autoregressive (MVAR) modeling techniques applied to multisite electrophysiological …
View article: Fast Topological Clustering with Wasserstein Distance
Fast Topological Clustering with Wasserstein Distance Open
The topological patterns exhibited by many real-world networks motivate the development of topology-based methods for assessing the similarity of networks. However, extracting topological structure is difficult, especially for large and de…