Bryan Nicol
YOU?
Author Swipe
View article: Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8 <sup>+</sup> Regulatory T Cells
Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8 <sup>+</sup> Regulatory T Cells Open
Altogether, these results suggest a defect in the number and function of CD8+CD45RClow Tregs during MS relapse and an association of CD8+CD45RClow Tregs dysfunction with MS severity. Thus, CD8+CD45RClow/neg T cells might bring new insights…
View article: An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis
An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8+ T cells involved in multiple sclerosis Open
Several lines of evidence support a key role for CD8+ T cells in central nervous system tissue damage of patients with multiple sclerosis. However, the precise phenotype of the circulating CD8+ T cells that may be recruited from the periph…
View article: IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients
IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients Open
The involvement of TEMRA CD8 is evident in a large array of immunological conditions ranging from auto- to allo-immunity. Nevertheless, the factors leading to their accumulation and activation remain ill-defined and, efficient therapeutics…
View article: Involvement of CD8+ T Cells in Multiple Sclerosis
Involvement of CD8+ T Cells in Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by focal demyelination patches associated with inflammatory infiltrates containing T lymphocytes. For decades, CD4(+) T cells have been rec…
View article: Expanded<scp>CD</scp>8 T‐cell sharing between periphery and<scp>CNS</scp>in multiple sclerosis
Expanded<span>CD</span>8 T‐cell sharing between periphery and<span>CNS</span>in multiple sclerosis Open
This study highlights the predominant implication of CD8(+) T cells in MS pathophysiology and demonstrates that potentially aggressive CD8(+) T cells can be easily identified and characterized from blood and CSF samples.