Barbara Nell
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View article: Myopia in Beagles in a Family of 12 Individuals
Myopia in Beagles in a Family of 12 Individuals Open
This case report investigated the cause of visual impairment at night in Beagle dogs in a family of 12 individuals. Four related adult male Beagles with impaired night vision and eight related Beagles (three females, five males) underwent …
View article: Detection of vasculogenic mimicry in equine ocular, oronasal, and genital squamous cell carcinoma
Detection of vasculogenic mimicry in equine ocular, oronasal, and genital squamous cell carcinoma Open
Squamous cell carcinoma (SCC) is the most common malignant tumor disease in horses. It predominantly affects the ocular, oronasal, and anogenital region. Equine SCC is difficult to treat, also because important aspects of SCC development a…
View article: Studying the Impact of the DDB2 T338M Missense Mutation on the Development of Equine Squamous Cell Carcinoma and Sarcoid
Studying the Impact of the DDB2 T338M Missense Mutation on the Development of Equine Squamous Cell Carcinoma and Sarcoid Open
A missense mutation in damage-specific DNA binding protein 2 (DDB2 c.1013 C>T; p.Thr338Met) has been described as a risk factor for ocular squamous cell carcinoma (OSCC) in the Haflinger breed. Here, we examined the impact of DDB2 C>T alle…
View article: Preserved bevacizumab (Avastin®) eye drops for application in multidose containers – an in-vitro characterisation
Preserved bevacizumab (Avastin®) eye drops for application in multidose containers – an in-vitro characterisation Open
Equivalence tests demonstrated that bevacizumab is stable after dilution, storage and preservation with BAC. Our study shows that preserved bevacizumab applied in mutidose containers can be considered as a cost-effective alternative to the…
View article: Lateral Tarsorrhaphy and Fixation on the Orbital Ligament to Correct Macroblepharon in Dogs: 77 Palpebral Fissures
Lateral Tarsorrhaphy and Fixation on the Orbital Ligament to Correct Macroblepharon in Dogs: 77 Palpebral Fissures Open
Purpose To describe a surgical method for correcting lower lid entropion, lateral canthal entropion, and macroblepharon. Methods Lid margins were incised at a 45° angle, and lateral lid margins and a rhomboid shaped piece of skin were rese…
View article: Retrospective study on <i>Encephalitozoon cuniculi</i> infections in 118 cat and 9 dog eyes
Retrospective study on <i>Encephalitozoon cuniculi</i> infections in 118 cat and 9 dog eyes Open
Purpose This study aims to inform about the clinical image, diagnostic possibilities, and treatment options for cats and dogs diagnosed with ocular encephalitozoonosis. Materials and Methods Medical records of 7 dogs and 75 cats with ocula…
View article: Isolation-protocol, characterization, and in-vitro performance of equine umbilical vein endothelial cells
Isolation-protocol, characterization, and in-vitro performance of equine umbilical vein endothelial cells Open
Angiogenesis plays a crucial role in various physiological and pathological conditions. However, research in equine angiogenesis is relative limited, necessitating the development of suitable in-vitro models. To effectively analyze angioge…
View article: Evaluation of ocular surface parameters before and after cryo‐ and laser therapy for distichiasis in dogs: A pilot study
Evaluation of ocular surface parameters before and after cryo‐ and laser therapy for distichiasis in dogs: A pilot study Open
Objective The aim of this pilot study was to establish a satisfactory, scientific approach to effectively compare quantitative measurements of various ocular surface parameters before and after surgical treatment in dogs suffering from dis…
View article: Adjunctive bevacizumab therapy in an equine corneal stromal invasive squamous cell carcinoma with a 53-months follow-up
Adjunctive bevacizumab therapy in an equine corneal stromal invasive squamous cell carcinoma with a 53-months follow-up Open
A 17-year-old Appaloosa mare was referred for evaluation of presumed refractory keratitis of the left eye. Gross examination revealed ocular discomfort and corneal neovascularization with a nasal focal opacification affecting approximately…
View article: Bevacizumab Efficiently Inhibits VEGF-Associated Cellular Processes in Equine Umbilical Vein Endothelial Cells: An In Vitro Characterization
Bevacizumab Efficiently Inhibits VEGF-Associated Cellular Processes in Equine Umbilical Vein Endothelial Cells: An In Vitro Characterization Open
Anti-VEGF agents were found to have clinical implications for the successful treatment of vascular-driven diseases in humans. In this study, a detailed biological characterization of bevacizumab in a variety of in vitro assays was carried …
View article: Morphology and volume of Meibomian glands ex vivo pre and post partial tarsal plate excision, cryotherapy and laser therapy in the dog using <scp>microCT</scp>
Morphology and volume of Meibomian glands ex vivo pre and post partial tarsal plate excision, cryotherapy and laser therapy in the dog using <span>microCT</span> Open
Objective To determine the morphology and volume of Meibomian glands (MG) of dogs with microCT before and after partial tarsal plate excision (PTPE), cryotherapy, and laser therapy. Procedure MicroCT scans were made of 12 upper lids (ULs) …
View article: Detection of Equine Papillomaviruses and Gamma-Herpesviruses in Equine Squamous Cell Carcinoma
Detection of Equine Papillomaviruses and Gamma-Herpesviruses in Equine Squamous Cell Carcinoma Open
Squamous cell carcinoma (SCC) seriously compromises the health and welfare of affected horses. Although robust evidence points to equine papillomavirus type 2 (EcPV2) causing genital lesions, the etiopathogenesis of equine SCC is still poo…
View article: Feline intralenticular <i>Encephalitozoon cuniculi</i>: three cases from California
Feline intralenticular <i>Encephalitozoon cuniculi</i>: three cases from California Open
Case series summary Three domestic shorthair cats from California presented to veterinary ophthalmologists with immature cataracts. Other presenting clinical signs included corneal edema, anisocoria, anterior uveitis, elevated intraocular …
View article: Immunohistochemical staining of immunoglobulin G in healthy equine, canine, and feline corneas
Immunohistochemical staining of immunoglobulin G in healthy equine, canine, and feline corneas Open
Objective Establishing an immunohistochemical approach for semi‐quantitative assessment of the presence of immunoglobulin G (IgG) in equine, canine, and feline corneas. Procedures Healthy corneas of horses, dogs, and cats, euthanized becau…
View article: Topical bevacizumab for the treatment of corneal vascularization in dogs: A case series
Topical bevacizumab for the treatment of corneal vascularization in dogs: A case series Open
Objective To evaluate the effect and safety of topical anti‐human vascular endothelial growth factor bevacizumab in dogs with persistent corneal vascularization. Animals studied Prospective case series of 15 adult dogs (20 eyes). Procedure…
View article: Labial and buccal minor salivary glands of the dog – location, three‐dimensional arrangement and histology
Labial and buccal minor salivary glands of the dog – location, three‐dimensional arrangement and histology Open
Objective Transplantation of minor salivary glands (MSGs) to the conjunctiva is a treatment option for patients suffering from dry eye disease. As there is not enough information about labial and buccal MSGs in dogs, the aim of this study …
View article: Clinical utility, dose determination, and safety of ocular contrast‐enhanced ultrasonography in horses: A pilot study
Clinical utility, dose determination, and safety of ocular contrast‐enhanced ultrasonography in horses: A pilot study Open
Objective To determine efficacy of contrast‐enhanced ultrasonography (CEUS) using different sulfur hexafluoride (SF6) doses to assess blood flow and perfusion in equine eyes and to evaluate safety of SF6 in horses. Procedures Ocular B‐mode…
View article: Quantitative, noninvasive assessment of intra‐ and extraocular perfusion by contrast‐enhanced ultrasonography and its clinical applicability in healthy dogs
Quantitative, noninvasive assessment of intra‐ and extraocular perfusion by contrast‐enhanced ultrasonography and its clinical applicability in healthy dogs Open
Objective To assess quantitative perfusion of intra‐ and extraocular regions of interest (ROIs) in conscious, healthy dogs utilizing contrast‐enhanced ultrasonography (CEUS); to compare varying enhancement with the first and second bolus i…
View article: Morphological and immunohistochemical characteristics of the equine corneal epithelium
Morphological and immunohistochemical characteristics of the equine corneal epithelium Open
Objective The morphology of the corneal epithelium in two age groups of horses is described. Distribution patterns of proliferation‐, differentiation‐, stem cell‐associated markers and cell junction proteins were assessed. Methods Corneal …
View article: Serum vascular endothelial growth factor changes and safety after topical anti‐human VEGF antibody bevacizumab in healthy dogs
Serum vascular endothelial growth factor changes and safety after topical anti‐human VEGF antibody bevacizumab in healthy dogs Open
Objective To evaluate ocular and general safety of topical anti‐human VEGF bevacizumab and the effect on serum vascular endothelial growth factor (VEGF) values in healthy dogs. Procedures Nine university‐owned beagles received 0.05 mL of 0…
View article: Circulating cell-free DNA does not harbour a diagnostic benefit in cats with feline diffuse iris melanomas
Circulating cell-free DNA does not harbour a diagnostic benefit in cats with feline diffuse iris melanomas Open
Objectives Feline diffuse iris melanoma (FDIM) is the most common malignant primary intraocular tumour in cats, with reported metastases rates between 19% and 63%. Currently, the only available diagnostic tool for a tentative diagnosis is …
View article: Effects of three blood derived products on equine corneal cells, an <i>in vitro</i> study
Effects of three blood derived products on equine corneal cells, an <i>in vitro</i> study Open
Summary Background Despite advances in therapy of corneal ulcerative diseases in horses, a vast number of cases require surgical intervention, due to poor response to treatment. Topical application of serum has been used for many years, ba…
View article: Density and distribution of feline conjunctival goblet cells
Density and distribution of feline conjunctival goblet cells Open
Objectives The objective of this study was to examine the density and distribution of goblet cells (GCs) in the feline conjunctiva and to investigate a potential effect of age and sex on GC density (GCD). Methods Thirty-nine eyes of 21 cat…
View article: Introduction of the use of thermography and thermometry in the diagnosis of uveitis in horses: a pilot project
Introduction of the use of thermography and thermometry in the diagnosis of uveitis in horses: a pilot project Open
Aims and objectives To date assessment of changes in ocular temperature, as a hallmark of uveitis in horses has not been determined. Therefore the aim of the current study was to determine whether ocular temperature is increased in acute u…