Explanipedia

Low circulating miR-190a-5p predicts progression of chronic kidney disease Open

David Baird, Jinnan Zang, Katie Connor, Oliver Teenan, Maximilian Reck , et al. · 2025

Major complications of percutaneous native and transplant kidney biopsy: a complete 10-year national prospective cohort study Open

Colin Geddes, Samira Bell, Kate Buck, Bryan R. Conway, Vishal Dey , et al. · 2025

Background Previous reports of incidence of major complications (MC) of kidney biopsy vary depending on definitions of MC, single or multicentre analysis, and prospective or retrospective data collection. We aimed to provide accurate, unbi…

Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype Open

Maximilian Reck, David Baird, Stefan Veizades, Callum Sutherland, Rachel Bell , et al. · 2025

Maladaptive proximal tubular (PT) epithelial cells have been implicated in progression of chronic kidney disease (CKD), however the complexity of epithelial cell states within the fibrotic niche remains incompletely understood. Hence, we i…

Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression Open

David Baird, Maximilian Reck, Ross Campbell, Marie-Helena Docherty, Piotr P. Janas , et al. · 2025

Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study Open

Emilie Lambourg, Edouard L. Fu, Stuart J. McGurnaghan, Bryan R. Conway, Neeraj Dhaun , et al. · 2024

Low circulating miR-190a-5p predicts progression of chronic kidney disease. Open

David Baird, Jinnan Zang, Katie Connor, Oliver Teenan, Ryan Wong , et al. · 2024

MicroRNAs (miRs) have the potential to be employed as diagnostic and prognostic biomarkers of chronic kidney disease (CKD) and are functionally important in disease pathogenesis. To identify novel miR biomarkers we performed small RNA-sequ…

Low circulating miR-190a-5p predicts progression of chronic kidney disease. Open

David Baird, Jinnan Zang, Katie Connor, Oliver Teenan, Ryan Wong , et al. · 2024

MicroRNAs (miRs) have the potential to be employed as diagnostic and prognostic biomarkers of chronic kidney disease (CKD) and are functionally important in disease pathogenesis. To identify novel miR biomarkers we performed small RNA-sequ…

Urinary Clusterin is a biomarker of renal epithelial senescence and predicts human kidney disease progression Open

David Baird, Maximillian Reck, Ross Campbell, Marie-Helena Docherty, Matthieu Vermeren , et al. · 2024

Cellular senescence drives organ fibrosis and ageing, and accumulating evidence supports the ability of senescence-depleting drugs to improve outcomes in experimental models of disease. The lack of non-invasive biomarkers represents a majo…

Multiomic analysis of human kidney disease identifies a tractable inflammatory, pro-fibrotic tubular cell phenotype Open

Bryan R. Conway, Maximilian Reck, David Baird, Callum Sutherland, Rachel Bell , et al. · 2024

Maladaptive proximal tubular cells have been implicated in failure of repair following renal injury in rodent models, however whether this translates to human kidney disease is unknown. Hence, we integrated snRNA-ATAC-seq with single-cell …

Exploration of Metabolomic Markers Associated With Declining Kidney Function in People With Type 2 Diabetes Mellitus Open

Justina Krasauskaite, Bryan R. Conway, Christopher J. Weir, Zhe Huang, Jackie F. Price · 2023

Background Metabolomics, the study of small molecules in biological systems, can provide valuable insights into kidney dysfunction in people with type 2 diabetes mellitus (T2DM), but prospective studies are scarce. We investigated the asso…

#5506 NATIVE KIDNEY BIOPSY: A NATIONAL SURVEY ON, DIAGNOSES AND OUTCOMES Open

Emily P. McQuarrie, Samira Bell, Jacqueline Campbell, Chrissie Watters, Joe Lakey , et al. · 2023

Background and Aims Since 2014, all adult native kidney biopsies undertaken in Scotland have been recorded by the Scottish Renal Registry (SRR). We aimed to report current data on indications for kidney biopsy, and outcomes following biops…

#3022 REDUCED TUBULAR MIR-190A-5P: A NOVEL BIOMARKER FOR STRATIFICATION OF PATIENTS WITH CHRONIC KIDNEY DISEASE Open

David Baird, Jinnan Zang, Ryan Wong, Katie Connor, Carolynn Cairns , et al. · 2023

Background and Aims Circulating microRNA (miRNAs) have been proposed as potential diagnostic and prognostic biomarkers and are functionally important in disease pathogenesis. In this study, we used an unbiased measurement of circulating mi…

#5475 SAFETY OF NATIVE AND TRANSPLANT KIDNEY BIOPSY IN A NATIONAL COHORT Open

Emily P. McQuarrie, Samira Bell, Jacqueline Campbell, Chrissie Watters, Joe Lakey , et al. · 2023

Background and Aims Safety of kidney biopsy is variably reported in different published series. Since 2014, all native kidney biopsies undertaken in the 9 adult renal units in Scotland have been recorded by the Scottish Renal Registry (SRR…

Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis Open

Eoin O’Sullivan, Katie J. Mylonas, Cuiyan Xin, David Baird, Cyril Carvalho , et al. · 2023

Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1 + ) cells are a major source of activated fibroblasts in multiple organs…

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis Open

Eoin O’Sullivan, Katie J. Mylonas, Rachel Bell, Cyril Carvalho, David Baird , et al. · 2022

Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with aging and after injury and are implicated in organ fibrosis, but the mechanisms by…

Frequency and Phenotype Associations of Rare Variants in 5 Monogenic Cerebral Small Vessel Disease Genes in 200,000 UK Biobank Participants Open

Amy Ferguson, Sophie Thrippleton, David Henshall, Ed Whittaker, Bryan R. Conway , et al. · 2022

While putative pathogenic rare variants in monogenic cSVD genes occur in 1:200 people in the UKB population, only approximately half of variant carriers have a relevant disease phenotype recorded in their linked health data. We could not r…

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis Open

Eoin O’Sullivan, Katie J. Mylonas, R. Bryan Bell, Cyril Carvalho, David Baird , et al. · 2022

Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with ageing and after injury and are implicated in organ fibrosis, but the mechanisms b…

Frequency and phenotype associations of rare variants in five monogenic cerebral small vessel disease genes in 200,000 UK Biobank participants with whole exome sequencing data Open

Amy Ferguson, Sophie Thrippleton, David Henshall, Ed Whittaker, Bryan R. Conway , et al. · 2021

Based on previous case reports and disease-based cohorts, a minority of patients with cerebral small vessel disease (cSVD) have a monogenic cause, with many also manifesting extra-cerebral phenotypes. We investigated the frequency, penetra…

scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain Open

Cara Brown, L. J. Mullins, Katrina Wesencraft, Gail McConnell, Mariana Beltrán , et al. · 2021

BACKGROUND/AIMS: The role of podocytes is well conserved across species from drosophila to teleosts, and mammals. Identifying the molecular markers that actively maintain the integrity of the podocyte will enable a greater understanding of…

O45: DEFINING CELL-ENRICHED MICRORNAS TO SUPPORT RATIONAL BIOMARKER SELECTION IN HUMAN RENAL TRANSPLANTATION Open

Katie Connor, Oliver Teenan, Rhodri Thomas, Victoria Banwell, S. J. Finnie , et al. · 2021

Introduction MicroRNAs are promising biomarkers of renal disease, however the cellular origin of their expression is usually unclear limiting their interpretation when measured in renal biopsies and urine. We hypothesised that by first def…

Identifying cell-enriched miRNAs in kidney injury and repair Open

Katie Connor, Oliver Teenan, Carolynn Cairns, Victoria Banwell, Rachel Thomas , et al. · 2020

Small noncoding RNAs, miRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression, or therapeutic efficacy. Bulk tissue small RNA-sequencing…

A National Registry Study of Patient and Renal Survival in Adult Nephrotic Syndrome Open

A. Kolb, Peter J. Gallacher, Jacqueline Campbell, Martin O’Neill, James R. Smith , et al. · 2020

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease Open

Bryan R. Conway, Eoin O’Sullivan, Carolynn Cairns, James O’Sullivan, Daniel J. Simpson , et al. · 2020

Significance Statement The innate immune system is central to injury and repair in the kidney, but the heterogeneity of myeloid cell subsets behind these processes is unknown. Complementary technologies—including bulk tissue transcriptomic…

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease Open

Bryan R. Conway, Eoin O’Sullivan, Carolynn Cairns, James O’Sullivan, Daniel J. Simpson , et al. · 2020

The kidney has a limited capacity to repair following injury, however, the endogenous reparative pathways are not well understood. Here we employ integrated droplet- and plate-based scRNA-seq in the murine reversible unilateral ureteric ob…

Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation Open

Natalie K. Jones, Kevin Stewart, Alicja Czopek, Robert Menzies, Adrian Thomson , et al. · 2020

GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and kidney, but roles in nonadipose tissues are poorl…

Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction Open

James O’Sullivan, Sarah Finnie, Oliver Teenan, Carolynn Cairns, Andy Boyd , et al. · 2019

Chronic kidney disease (CKD) is prevalent worldwide and is associated with significant co-morbidities including cardiovascular disease (CVD). Traditionally, the subtotal nephrectomy (remnant kidney) experimental model has been performed in…

The Efficacy of Puromycin and Adriamycin for Induction of Glomerular Failure in Larval Zebrafish Validated by an Assay of Glomerular Permeability Dynamics Open

S. Rider, Finnius A. Bruton, Richard Collins, Bryan R. Conway, John J. Mullins · 2018

Defects in the glomerular filtration barrier (GFB) play a major role in the onset of human renal diseases. Highly ramified glomerular cells named podocytes are a critical component of the GFB. Injury to podocytes results in abnormal excret…

Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes Open

Sara Jenks, Bryan R. Conway, Stela McLachlan, Wei Leng Teoh, R. Williamson , et al. · 2017

Renal disease pathophysiology and treatment: contributions from the rat Open

L. J. Mullins, Bryan R. Conway, Robert Menzies, Laura Denby, John J. Mullins · 2016

The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments i…

Wnt6: another player in the yin and yang of renal Wnt signaling Open

Laura Denby, Bryan R. Conway · 2016

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