Bryan Stanfill
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View article: Sensing analytical instrument parameters, specimen characteristics, or both from sparse datasets
Sensing analytical instrument parameters, specimen characteristics, or both from sparse datasets Open
Disclosed are methods for sensing conditions of an electron microscope system and/or a specimen analyzed thereby. Also disclosed are sensor systems and electron microscope systems able to sense system conditions, and/or conditions of the s…
View article: Plasma protein biomarkers predict both the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity: the TEDDY Study
Plasma protein biomarkers predict both the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity: the TEDDY Study Open
Type 1 diabetes (T1D) results from an autoimmune destruction of pancreatic β cells. A significant gap in understanding the disease cause is the lack of predictive biomarkers for each of its developmental stages. Here, we conducted a blinde…
View article: Deciphering the microbial and molecular responses of geographically diverse Setaria accessions grown in a nutrient-poor soil
Deciphering the microbial and molecular responses of geographically diverse Setaria accessions grown in a nutrient-poor soil Open
The microbial and molecular characterization of the ectorhizosphere is an important step towards developing a more complete understanding of how the cultivation of biofuel crops can be undertaken in nutrient poor environments. The ectorhiz…
View article: Circulating Tumour Cell Numbers Correlate with Platelet Count and Circulating Lymphocyte Subsets in Men with Advanced Prostate Cancer: Data from the ExPeCT Clinical Trial (CTRIAL-IE 15-21)
Circulating Tumour Cell Numbers Correlate with Platelet Count and Circulating Lymphocyte Subsets in Men with Advanced Prostate Cancer: Data from the ExPeCT Clinical Trial (CTRIAL-IE 15-21) Open
Interactions between circulating tumour cells (CTCs) and platelets are thought to inhibit natural killer(NK)-cell-induced lysis. We attempted to correlate CTC numbers in men with advanced prostate cancer with platelet counts and circulatin…
View article: Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2
Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2 Open
This report summarizes and analyzes the data collected on a second test matrix of 42 low-activity waste (LAW) glass compositions intended to expand the LAW glass composition region over which glass property-composition models are valid. Th…
View article: Deciphering the Source of Primary Biological Aerosol Particles: A Pollen Case Study
Deciphering the Source of Primary Biological Aerosol Particles: A Pollen Case Study Open
Primary biological aerosol particles (PBAPs) are microscopic solids suspended in the atmosphere emitted by biological systems and play critical roles in the atmosphere and the atmosphere–biosphere system, impacting human health, climate, a…
View article: Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2
Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2 Open
The U.S. Department of Energy’s (DOE) Office of River Protection (ORP) requested Pacific Northwest National Laboratory (PNNL) to support the River Protection Project vitrification in an effort to support operations upon completion of start…
View article: Deciphering the microbial and molecular responses of geographically diverse Setaria accessions grown in a nutrient-poor soil
Deciphering the microbial and molecular responses of geographically diverse Setaria accessions grown in a nutrient-poor soil Open
The microbial and molecular characterization of the ectorhizosphere is an important step towards developing a more complete understanding of how the cultivation of biofuel crops can be undertaken in nutrient poor environments. The ectorhiz…
View article: Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial
Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial Open
Background Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine the effectiveness of a structured exercise programme in modulating l…
View article: Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers
Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers Open
Background The Environmental Determinants of the Diabetes in the Young (TEDDY) study has prospectively followed, from birth, children at increased genetic risk of type 1 diabetes. TEDDY has collected heterogenous data longitudinally to gai…
View article: Enhanced Hanford Low-Activity Waste Glass Property Data Development (Phase 3)
Enhanced Hanford Low-Activity Waste Glass Property Data Development (Phase 3) Open
This work was performed for the U.S. Department of Energy (DOE) Office of River Protection (ORP) to provide expert evaluation and experimental work in support of the River Protection Project vitrification technology development1. The long-…
View article: Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2
Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2 Open
This report summarizes and analyzes the data collected on a second test matrix of 42 low-activity waste (LAW) glass compositions intended to expand the LAW glass composition region over which glass property-composition models are valid. Th…
View article: Machine Learning for Rapid Biomarker Discovery via Image-Omic Fusion
Machine Learning for Rapid Biomarker Discovery via Image-Omic Fusion Open
In this project we proposed to accelerate biomarker discovery and improve disease prediction by combining image and omic data using a single, unified modelling approach. We hypothesized that much richer information could be derived from bo…
View article: Liquidus Temperature: Assessing Standard Glasses for Furnace Calibration
Liquidus Temperature: Assessing Standard Glasses for Furnace Calibration Open
Standard glasses are used to ensure accurate liquidus temperature measurements and furnace temperatures. The supply of the standard glasses used at Pacific Northwest National Laboratory (Standard Reference Material 773 [SRM-773]) has been …
View article: Machine learning predictions of electronic couplings for charge transport calculations of P3HT
Machine learning predictions of electronic couplings for charge transport calculations of P3HT Open
The purpose of this work is to lower the computational cost of predicting charge mobilities in organic semiconductors, which will benefit the screening of candidates for inexpensive solar power generation. We characterize efforts to minimi…
View article: Controlling the spatio-temporal dose distribution during STEM imaging by subsampled acquisition: <i>In-situ</i> observations of kinetic processes in liquids
Controlling the spatio-temporal dose distribution during STEM imaging by subsampled acquisition: <i>In-situ</i> observations of kinetic processes in liquids Open
Subsampled image acquisition followed by image inpainting in a scanning transmission electron microscope is a novel approach to control dose and increase the image frame rate during experiments, thereby allowing independent control of the …
View article: Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2
Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2 Open
The U.S. Department of Energy’s (DOE) Office of River Protection (ORP) requested Pacific Northwest National Laboratory (PNNL) to provide expert evaluation and experimental work in support of the River Protection Project vitrification techn…
View article: When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All?
When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All? Open
Malignant pleural mesothelioma (MPM) is an aggressive inflammatory cancer with a poor survival rate. Treatment options are limited at best and drug resistance is common. Thus, there is an urgent need to identify novel therapeutic targets i…
View article: <i>pmartR</i>: Quality Control and Statistics for Mass Spectrometry-Based Biological Data
<i>pmartR</i>: Quality Control and Statistics for Mass Spectrometry-Based Biological Data Open
Prior to statistical analysis of mass spectrometry (MS) data, quality control (QC) of the identified biomolecule peak intensities is imperative for reducing process-based sources of variation and extreme biological outliers. Without this s…
View article: Extending Classification Algorithms to Case-Control Studies
Extending Classification Algorithms to Case-Control Studies Open
Classification is a common technique applied to ’omics data to build predictive models and identify potential markers of biomedical outcomes. Despite the prevalence of case-control studies, the number of classification methods available to…
View article: stanfill/QC-ART
stanfill/QC-ART Open
Dynamic, unsupervised quality control methodology for mass spectrometry
View article: pmartR/peppuR
pmartR/peppuR Open
peppuR provides a machine learning pipeline for the integrative analysis of multiple and disparate data types coupled with an optimized ensemble feature selection method. The peppuR package is a suite of tools used to discover important in…
View article: Implementing Sparse Sub-Sampling Methods for Low-Dose/High Speed STEM
Implementing Sparse Sub-Sampling Methods for Low-Dose/High Speed STEM Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Using Sub-Sampling/Inpainting to Control the Kinetics and Observation Efficiency of Dynamic Processes in Liquids
Using Sub-Sampling/Inpainting to Control the Kinetics and Observation Efficiency of Dynamic Processes in Liquids Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data
Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data Open
Liquid chromatography-mass spectrometry (LC-MS)-based proteomics studies of large sample cohorts can easily require from months to years to complete. Acquiring consistent, high-quality data in such large-scale studies is challenging becaus…