Bryan W. Luikart
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View article: Dentate Granule Cell Capacitance Is Stable across the Light/Dark Cycle
Dentate Granule Cell Capacitance Is Stable across the Light/Dark Cycle Open
The plasma membrane acts as a capacitor that plays a critical role in neuronal excitability and signal propagation. Neuronal capacitance is proportional to the area of the cell membrane; thus it is often used as a measure of the cell size …
View article: Pathogenic variants in autism gene <i>KATNAL2</i> cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics
Pathogenic variants in autism gene <i>KATNAL2</i> cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamics Open
Enlargement of the cerebrospinal fluid (CSF)–filled brain ventricles (cerebral ventriculomegaly), the cardinal feature of congenital hydrocephalus (CH), is increasingly recognized among patients with autism spectrum disorders (ASD). KATNAL…
View article: Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids Open
Mutations in the phosphatase and tensin homolog (PTEN) gene are associated with severe neurodevelopmental disorders. Loss of PTEN leads to hyperactivation of the mechanistic target of rapamycin (mTOR), which functions in two distinct prote…
View article: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells
Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells Open
The cell-type-specific expression of ligand/receptor and cell-adhesion molecules is a fundamental mechanism through which neurons regulate connectivity. Here, we determine a functional relevance of the long-established mutually exclusive e…
View article: Author Response: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells
Author Response: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells Open
View article: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells
Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells Open
Summary The cell-type specific expression of ligand/receptor and cell-adhesion molecules is a fundamental mechanism through which neurons regulate connectivity. Here we determine a functional relevance of the long-established mutually excl…
View article: Author Response: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells
Author Response: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells Open
The cell-type specific expression of ligand/receptor and cell-adhesion molecules is a fundamental mechanism through which neurons regulate connectivity. Here we determine a functional relevance of the long-established mutually exclusive ex…
View article: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells
Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells Open
Summary The cell-type specific expression of ligand/receptor and cell-adhesion molecules is a fundamental mechanism through which neurons regulate connectivity. Here we determine a functional relevance of the long-established mutually excl…
View article: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells
Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells Open
The cell-type-specific expression of ligand/receptor and cell-adhesion molecules is a fundamental mechanism through which neurons regulate connectivity. Here, we determine a functional relevance of the long-established mutually exclusive e…
View article: TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons
TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons Open
View article: Toward a better understanding of PHTS heterogeneity: commentary on ‘Cell-type specific deficits in <i>PTEN</i>-mutant cortical organoids converge on abnormal circuit activity’
Toward a better understanding of PHTS heterogeneity: commentary on ‘Cell-type specific deficits in <i>PTEN</i>-mutant cortical organoids converge on abnormal circuit activity’ Open
Journal Article Toward a better understanding of PHTS heterogeneity: commentary on 'Cell-type specific deficits in PTEN-mutant cortical organoids converge on abnormal circuit activity' Get access Zhibing Tan, Zhibing Tan Genomic Medicine I…
View article: Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells
Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells Open
Summary The cell-type specific expression of ligand/receptor and cell-adhesion molecules is a fundamental mechanism through which neurons regulate connectivity. Here we determine a functional relevance of the long-established mutually excl…
View article: Dual impact of PTEN mutation on CSF dynamics and cortical networks via the dysregulation of neural precursors and their interneuron descendants
Dual impact of PTEN mutation on CSF dynamics and cortical networks via the dysregulation of neural precursors and their interneuron descendants Open
SUMMARY Expansion of the cerebrospinal fluid (CSF)-filled cerebral ventricles (ventriculomegaly) is the quintessential feature of congenital hydrocephalus (CH) but also seen in autism spectrum disorder (ASD) and several neuropsychiatric di…
View article: TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons
TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons Open
Genetic variation in the transcription factor 4 ( TCF4) gene is associated with risk for a variety of developmental and psychiatric conditions, which includes a syndromic form of ASD called Pitt Hopkins Syndrome (PTHS). TCF4 encodes an act…
View article: mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures
mTORC2 Inhibition Improves Morphological Effects of PTEN Loss, But Does Not Correct Synaptic Dysfunction or Prevent Seizures Open
Hyperactivation of PI3K/PTEN-mTOR signaling during neural development is associated with focal cortical dysplasia (FCD), autism, and epilepsy. mTOR can signal through two major hubs, mTORC1 and mTORC2, both of which are hyperactive followi…
View article: Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss
Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss Open
View article: <i>Pten</i> heterozygosity restores neuronal morphology in fragile X syndrome mice
<i>Pten</i> heterozygosity restores neuronal morphology in fragile X syndrome mice Open
Significance Phosphatase and tensin homolog protein (PTEN) and fragile X mental retardation protein (FMRP) play a vital role in neuronal development and function. This work provides new evidence for the genetic interaction of Pten and Fmr1…
View article: Single-cell RNA sequencing of conditional <i>Pten</i> knockout neurons in mice
Single-cell RNA sequencing of conditional <i>Pten</i> knockout neurons in mice Open
PTEN is a well-known tumor suppressor whose mutations are also strongly associated with Autism Spectrum Disorder (ASD). The activity and function of PTEN in neurons have been studied extensively in various settings, whereas animal models o…
View article: PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate
PTEN Regulates Dendritic Arborization by Decreasing Microtubule Polymerization Rate Open
Phosphatase and tensin homolog (PTEN) is a major negative regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway. Loss-of-function mutations in PTEN have been found in a subset of patients …
View article: Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease Open
Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeostasis of phosphatidylinositol 4,5-bispho…
View article: Dreadds: Use and application in behavioral neuroscience.
Dreadds: Use and application in behavioral neuroscience. Open
Technological advances over the last decade are changing the face of behavioral neuroscience research. Here we review recent work on the use of one such transformative tool in behavioral neuroscience research, chemogenetics (or Designer Re…
View article: Activity-dependent dendritic elaboration requires Pten
Activity-dependent dendritic elaboration requires Pten Open
View article: Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy
Restrained Dendritic Growth of Adult-Born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy Open
The dentate gyrus (DG) is a region of the adult rodent brain that undergoes continuous neurogenesis. Seizures and loss or dysfunction of GABAergic synapses onto adult-born dentate granule cells (GCs) alter their dendritic growth and migrat…
View article: The Role of PTEN in Neurodevelopment
The Role of PTEN in Neurodevelopment Open
PTEN is a lipid and protein phosphatase that regulates cell growth and survival. Mutations to PTEN are highly penetrant for autism spectrum disorder (ASD). Here, we briefly review the evidence linking PTEN mutations to ASD and the mouse mo…
View article: The Role of Neurogenesis in Brain Disorders
The Role of Neurogenesis in Brain Disorders Open
View article: A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma
A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma Open
Informed by the genetic alterations observed in human GBM, we engineered a novel mouse model of proneural GBM. While reflecting many of the advantages of transgenic mice, this model allows for the facile in vivo testing of gene function in…
View article: MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation
MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation Open
Neurogenesis is a highly-regulated process occurring in the dentate gyrus that has been linked to learning, memory, and antidepressant efficacy. MicroRNAs (miRNAs) have been previously shown to play an important role in the regulation of n…
View article: A Neurodevelopmental Perspective for Autism-Associated Gene Function
A Neurodevelopmental Perspective for Autism-Associated Gene Function Open
Large-scale genetic sequencing studies have identified a wealth of genes in which mutations are associated with autism spectrum disorder (ASD). Understanding the biological function of these genes sheds light onto the neurodevelopmental ba…
View article: A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse
A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse Open
View article: Can fearlessness come in a tiny package?
Can fearlessness come in a tiny package? Open
A molecule called microRNA-153 helps to prevent rats associating new environments with fear.