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View article: Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model Open
View article: Predatory Bacteria can Reduce<i>Pseudomonas aeruginosa</i>Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model
Predatory Bacteria can Reduce<i>Pseudomonas aeruginosa</i>Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model Open
Purpose Pseudomonas aeruginosa keratitis is a severe ocular infection that can lead to perforation of the cornea. In this study we evaluated the role of bacterial quorum sensing in generating corneal perforation and bacterial proliferation…
View article: Investigating the Transient Regenerative Potential of Cardiac Muscle Using a Neonatal Pig Partial Apical Resection Model
Investigating the Transient Regenerative Potential of Cardiac Muscle Using a Neonatal Pig Partial Apical Resection Model Open
Researchers have shown that adult zebrafish have the potential to regenerate 20% of the ventricular muscle within two months of apex resection, and neonatal mice have the capacity to regenerate their heart after apex resection up until day…
View article: Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa
Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa Open
View article: Spatial distribution and network morphology of epicardial, endocardial, interstitial, and Purkinje cell-associated elastin fibers in porcine left ventricle
Spatial distribution and network morphology of epicardial, endocardial, interstitial, and Purkinje cell-associated elastin fibers in porcine left ventricle Open
Cardiac extracellular matrices (ECM) play crucial functional roles in cardiac biomechanics. Previous studies have mainly focused on collagen, the major structural ECM in heart wall. The role of elastin in cardiac mechanics, however, is poo…
View article: A Workflow for 3D Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network
A Workflow for 3D Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network Open
A comprehensive characterization of the 3D vascular network of the optic nerve head (ONH) is critical to understanding eye physiology and pathology. Current in vivo imaging technologies, however, do not have simultaneous high spatial resol…
View article: Lamina cribrosa vessel and collagen beam networks are distinct
Lamina cribrosa vessel and collagen beam networks are distinct Open
View article: Lamina cribrosa vessel and collagen beam networks are distinct
Lamina cribrosa vessel and collagen beam networks are distinct Open
Our goal was to analyze the spatial interrelation between vascular and collagen networks in the lamina cribrosa (LC). Specifically, we quantified the percentages of collagen beams with/without vessels and of vessels inside/outside of colla…
View article: 3D eye-specific analysis of factors influencing lamina cribrosa oxygen concentration
3D eye-specific analysis of factors influencing lamina cribrosa oxygen concentration Open
View article: Front Cover
Front Cover Open
Instant polarized light microscopy (IPOL) allows for direct visualization of collagen with a single image encoding orientation and retardance in color and intensity, respectively, without post‐processing. The high spatiotemporal resolution…
View article: Biomechanical properties of acellular scar ECM during the acute to chronic stages of myocardial infarction
Biomechanical properties of acellular scar ECM during the acute to chronic stages of myocardial infarction Open
View article: So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult
So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult Open
Missing LC connective tissues can mitigate IOP-induced neural tissue insult, suggesting that the role of the LC connective tissues is more complex than simply fortifying against IOP. The numerical models further predict that partial loss o…
View article: Instant polarized light microscopy for imaging collagen microarchitecture and dynamics
Instant polarized light microscopy for imaging collagen microarchitecture and dynamics Open
Collagen fibers are a primary load‐bearing component of connective tissues and are therefore central to tissue biomechanics and pathophysiology. Understanding collagen architecture and behavior under dynamic loading requires a quantitative…
View article: Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases
Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases Open
Although high capillary tortuosity is sometimes regarded as potentially problematic because it can reduce blood flow, LC capillary tortuosity may provide slack that mitigates against reduced flow and structural damage caused by excessive s…
View article: Collagen fiber interweaving is central to sclera stiffness
Collagen fiber interweaving is central to sclera stiffness Open
View article: Factors influencing oxygen concentration in the lamina cribrosa
Factors influencing oxygen concentration in the lamina cribrosa Open
View article: Local decreases in lamina cribrosa oxygen concentration under elevated IOP are not correlated with the degree of IOP-induced compression
Local decreases in lamina cribrosa oxygen concentration under elevated IOP are not correlated with the degree of IOP-induced compression Open
View article: Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution
Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution Open
View article: One beam-one vessel is not true: lamina cribrosa vessel and collagen beam networks have distinct topologies
One beam-one vessel is not true: lamina cribrosa vessel and collagen beam networks have distinct topologies Open
View article: Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics
Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics Open
View article: Heart valve tissue‐derived hydrogels: Preparation and characterization of mitral valve chordae, aortic valve, and mitral valve gels
Heart valve tissue‐derived hydrogels: Preparation and characterization of mitral valve chordae, aortic valve, and mitral valve gels Open
Heart valve (HV) diseases are among the leading causes of death and continue to threaten public health worldwide. The current clinical options for HV replacement include mechanical and biological prostheses. However, an ongoing problem wit…
View article: Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues
Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues Open
Collagen is a major constituent of the eye and understanding its architecture and biomechanics is critical to preserve and restore vision. We, recently, demonstrated polarized light microscopy (PLM) as a powerful technique for measuring pr…
View article: Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams
Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams Open
Our results suggest heterogeneity in LC beam mechanical properties. Thin beams were less wavy than their thicker counterparts, suggesting that thin beams may stiffen at lower IOP than thick beams. This difference may allow thin beams to su…
View article: Don’t judge a beam by its width; thin lamina cribrosa beams have different collagen microstructure than thick beams
Don’t judge a beam by its width; thin lamina cribrosa beams have different collagen microstructure than thick beams Open
View article: Simultaneous in-situ visualization and quantification of lamina cribrosa collagen beams and capillaries at normal and elevated IOPs
Simultaneous in-situ visualization and quantification of lamina cribrosa collagen beams and capillaries at normal and elevated IOPs Open
Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera Open
View article: Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear
Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear Open
In this study, the damage evolution of liver tissue was quantified at the microstructural level under tensile, compression, and shear loading conditions using an interrupted mechanical testing method. To capture the internal microstructura…
View article: Infarcted rat myocardium: Data from biaxial tensile and uniaxial compressive testing and analysis of collagen fibre orientation
Infarcted rat myocardium: Data from biaxial tensile and uniaxial compressive testing and analysis of collagen fibre orientation Open
Myocardial infarction was experimentally induced in rat hearts and harvested immediately, 7, 14 and 28 days after the infarction induction. Anterior wall infarct samples underwent biaxial tensile and uniaxial compressive testing. Orientati…
View article: Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System
Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System Open
There is a great need for living valve replacements for patients of all ages. Such constructs could be built by tissue engineering, with perspective of the unique structure and biology of the aortic root. The aortic valve root is composed …
View article: Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma
Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma Open
Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these inj…