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View article: Acute aortic syndromes after esophageal endoscopic submucosal dissection
Acute aortic syndromes after esophageal endoscopic submucosal dissection Open
Background Endoscopic Submucosal Dissection (ESD) is established as a primary therapeutic approach for early esophageal cancer, with perforation, bleeding, and stricture recognized as the most significant complications. Current evidence re…
View article: Single-cell and spatial transcriptomic analysis reveal cellular heterogeneity and cancer cell-intrinsic major histocompatibility complex II expression in urothelial carcinoma
Single-cell and spatial transcriptomic analysis reveal cellular heterogeneity and cancer cell-intrinsic major histocompatibility complex II expression in urothelial carcinoma Open
Muscle-invasive (MI) urothelial carcinoma (UC) is a clinically challenging malignancy with a poor prognosis. Understanding the cellular dynamics that drive UC progression is critical for the development of optimized therapeutic strategies.…
View article: Clinical characteristics and survival analysis of cancer of unknown primary
Clinical characteristics and survival analysis of cancer of unknown primary Open
Cancer of unknown primary (CUP) is a diagnosis that the primary lesion cannot be confirmed by a series of imaging, endoscopic and pathological examinations. The present study aimed to assess the clinical characteristics and survival outcom…
View article: I-PAttnGAN: An Image-Assisted Point Cloud Completion Network Based on Attention GAN
I-PAttnGAN: An Image-Assisted Point Cloud Completion Network Based on Attention GAN Open
Ensuring the consistency and accuracy of point cloud data is crucial for building 3D scenes. However, obtaining dense and uniformly distributed features is challenging due to limitations in LiDAR hardware. The presence of sparse regions in…
View article: Regulation of Cancer Metastasis by PAK2
Regulation of Cancer Metastasis by PAK2 Open
PAK2 is a serine-threonine kinase and a member of the p21-activated kinase (PAK) family. PAK2 is activated by GTP-bound rho family GTPases, Rac, and Cdc42, and it regulates actin dynamics, cell adhesion to the extracellular matrix, and cel…
View article: ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation
ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation Open
Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR [ db/db (diabetes)] and leptin [ ob/ob (obese)] are not identical, and the cause remains unclear. Here, we show that db/db …
View article: Synthesis and biological evaluation of novel 1,2,3-triazole hybrids of cabotegravir: identification of potent antitumor activity against lung cancer
Synthesis and biological evaluation of novel 1,2,3-triazole hybrids of cabotegravir: identification of potent antitumor activity against lung cancer Open
In pursuit of discovering novel anticancer agents, we designed and synthesized a series of novel 1,2,3-triazole hybrids based on cabotegravir analogues. These compounds were subjected to initial biological evaluations to assess their antic…
View article: Identifification of amino acid metabolic signature to predict prognosis and guide clinical therapy in patients with Hepatocellular carcinoma
Identifification of amino acid metabolic signature to predict prognosis and guide clinical therapy in patients with Hepatocellular carcinoma Open
Background The high heterogeneity of Hepatocellular carcinoma (HCC) has led to poor clinical outcomes. The critical role of amino acid metabolic reprogramming in tumor growth is gradually emerging. However, amino acid metabolism in HCC is …
View article: Pan-cancer analysis of the prognostic and immunological role of GJB2: a potential target for survival and immunotherapy
Pan-cancer analysis of the prognostic and immunological role of GJB2: a potential target for survival and immunotherapy Open
Background GJB2 plays an essential role in the growth and progression of several cancers. However, asystematic pan-cancer analysis of GJB2 is lacking. Therefore, in this study, we performed a comprehensive pan-cancer analysis to determine …
View article: SDHB reduction promotes oral lichen planus by impairing mitochondrial respiratory function
SDHB reduction promotes oral lichen planus by impairing mitochondrial respiratory function Open
Our study suggests that SDHB reduction promotes OLP by impairing mitochondrial respiratory function.
View article: LncRNA XIST promotes metastasis in ESCC by sponging miR-34a to regulate ZEB1 Expression
LncRNA XIST promotes metastasis in ESCC by sponging miR-34a to regulate ZEB1 Expression Open
Objective LncRNA X-inactive specific transcript (XIST) is the master regulator of transcriptional silencing of X chromosome. We will study the mechanism that XIST regulates the metastasis of ESCC by regulating ZEB1. Materials and Methods W…
View article: A peptoid interleukin‐15 receptor antagonist suppresses inflammation and arthritis in mice
A peptoid interleukin‐15 receptor antagonist suppresses inflammation and arthritis in mice Open
Objective To discover a novel peptoid antagonist that targets the interleukin‐15 (IL‐15) receptor and to evaluate its therapeutic efficacy in the treatment of inflammation and arthritis. Methods A new compound (IFRA3, interleukin‐15 recept…
View article: Distribution characteristics of SARS-CoV-2 IgM and IgG in false-positive results detected by Chemiluminescent immunoassay
Distribution characteristics of SARS-CoV-2 IgM and IgG in false-positive results detected by Chemiluminescent immunoassay Open
There have been several false-positive results in the antibody detection of the COVID-19. This study aims to analyze the distribution characteristics of SARS-CoV-2 IgM and IgG in false-positive results detected using chemiluminescent immun…
View article: Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19
Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19 Open
Background: Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection, without any available targeted therapies. The high mortality rate of COVID-19 is speculated to be related to immune damage. Methods: In thi…
View article: “Molecular Masks” for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry
“Molecular Masks” for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry Open
Coronavirus Disease 2019 (COVID-19) remains a global health crisis, despite the development and success of vaccines in certain countries. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, uses it…
View article: Long Non-Coding RNA JPX Contributes to Tumorigenesis by Regulating miR-5195-3p/VEGFA in Non-Small Cell Lung Cancer
Long Non-Coding RNA JPX Contributes to Tumorigenesis by Regulating miR-5195-3p/VEGFA in Non-Small Cell Lung Cancer Open
JPX facilitated proliferation, colony number, invasion, migration, EMT, and repressed apoptosis by miR-5195-3p/VEGFA axis, offering a possible therapeutic strategy for NSCLC.
View article: <p>A Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle</p>
A Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle Open
Metal nanoparticles are being extensively used in biomedical fields due to their small size-to-volume ratio and extensive thermal stability. Gold nanoparticles (AuNPs) are an obvious choice for biomedical applications due to their amenabil…
View article: The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series
The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series Open
Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. However, the quality control of CP and individual variation in patients in different studies make it rathe…
View article: Combined effect of recombinant human adenovirus p53 and curcumin in the treatment of liver cancer
Combined effect of recombinant human adenovirus p53 and curcumin in the treatment of liver cancer Open
The development of an effective therapeutic intervention for liver cancer is a worldwide challenge that remains to be adequately addressed. Of note, TP53, which encodes the p53 protein, is an important tumor suppressor gene, 61% of TP53 is…
View article: Chemopreventive Agent 3,3′-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells
Chemopreventive Agent 3,3′-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells Open
3,3′-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. …