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View article: Shared M0 macrophage infiltration-related gene signatures in osteoarthritis and osteomyelitis by integrating bulk and single-cell RNA transcriptome
Shared M0 macrophage infiltration-related gene signatures in osteoarthritis and osteomyelitis by integrating bulk and single-cell RNA transcriptome Open
This study identified five shared M0R-DEGs between OA and OM, linked to immune activation and response in various immune diseases. The diagnostic model revealed shared M0R-DEGs have good diagnostic efficacy, with significant differences in…
View article: Metabolomic profiling reveals novel biomarkers and therapeutic targets in Legg-Calvé-Perthes disease: a comprehensive analysis of peripheral blood and endothelial function
Metabolomic profiling reveals novel biomarkers and therapeutic targets in Legg-Calvé-Perthes disease: a comprehensive analysis of peripheral blood and endothelial function Open
Introduction Legg-Calvé-Perthes disease (LCPD) is juvenile idiopathic femoral head avascular necrosis with unclear pathophysiology. We aimed to identify circulating metabolic biomarkers and clarify the roles of peripheral inflammation and …
View article: Research Progress on Digital PCR in Detection of Foodborne Pathogenic Microorganisms
Research Progress on Digital PCR in Detection of Foodborne Pathogenic Microorganisms Open
Foodborne pathogenic microorganism is one of the main cause of food poisoning. Therefore, it is urgent to develop sensitive, accurate and fast detection methods for foodborne pathogenic microorganisms to prevent the contaminated food. As a…
View article: <scp>E3</scp> ubiquitin ligase <scp>TaSDIR1‐4A</scp> activates membrane‐bound transcription factor <scp>TaWRKY29</scp> to positively regulate drought resistance
<span>E3</span> ubiquitin ligase <span>TaSDIR1‐4A</span> activates membrane‐bound transcription factor <span>TaWRKY29</span> to positively regulate drought resistance Open
Summary Drought is a deleterious abiotic stress factor that constrains crop growth and development. Post‐translational modification of proteins mediated by the ubiquitin–proteasome system is an effective strategy for directing plant respon…
View article: Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response
Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response Open
This repository contains preprocessed resting-state fMRI data including two datasets of obsessive-compulsive disorder (OCD): patients in baseline and patients with capsulotomy. The baseline dataset consists 104 OCD patients and 82 healthy …
View article: Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response
Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response Open
This repository contains preprocessed resting-state fMRI data including two datasets of obsessive-compulsive disorder (OCD): patients in baseline and patients with capsulotomy. The baseline dataset consists 104 OCD patients and 82 healthy …
View article: Noncoding transcripts are linked to brain resting-state activity in non-human primates
Noncoding transcripts are linked to brain resting-state activity in non-human primates Open
Brain-derived transcriptomes are known to correlate with resting-state brain activity in humans. Whether this association holds in nonhuman primates remains uncertain. Here, we search for such molecular correlates by integrating 757 transc…
View article: Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning
Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning Open
Machine learning approaches are increasingly being applied to neuroimaging data from patients with psychiatric disorders to extract brain-based features for diagnosis and prognosis. The goal of this review is to discuss recent practices fo…
View article: IAG Regulates the Expression of Cytoskeletal Protein-Encoding Genes in Shrimp Testis
IAG Regulates the Expression of Cytoskeletal Protein-Encoding Genes in Shrimp Testis Open
Insulin-like androgenic gland hormone (IAG) is the master regulator of sexual differentiation and testis development in male crustaceans. However, the molecular mechanism on how IAG functions during testis development is still largely unkn…
View article: Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: MicroRNA editing level is a potential novel biomarker
Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: MicroRNA editing level is a potential novel biomarker Open
Background: With the continued advancement of RNA-seq (RNA-sequencing), microRNA (miRNA) editing events have been demonstrated to play an important role in different malignancies. However, there is yet no description of the miRNA editing e…
View article: TaNBR1, a Novel Wheat NBR1-like Domain Gene Negatively Regulates Drought Stress Tolerance in Transgenic Arabidopsis
TaNBR1, a Novel Wheat NBR1-like Domain Gene Negatively Regulates Drought Stress Tolerance in Transgenic Arabidopsis Open
Drought stress is an important factor that severely affects crop yield and quality. Autophagy has a crucial role in the responses to abiotic stresses. In this study, we explore TaNBR1 in response to drought stress. Expression of the TaNBR1…
View article: Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography
Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography Open
Resolving trajectories of axonal pathways in the primate prefrontal cortex remains crucial to gain insights into higher-order processes of cognition and emotion, which requires a comprehensive map of axonal projections linking demarcated s…
View article: Characterization of the Dual Functions of LvCrustinVII from Litopenaeus vannamei as Antimicrobial Peptide and Opsonin
Characterization of the Dual Functions of LvCrustinVII from Litopenaeus vannamei as Antimicrobial Peptide and Opsonin Open
Crustin are a family of antimicrobial peptides that play an important role in protecting against pathogens infection in the innate immune system of crustaceans. Previously, we identified several novel types of crustins, including type VI a…
View article: Author response: Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography
Author response: Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Abstract Resolving traject…
View article: Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution: relevance to diffusion tractography
Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution: relevance to diffusion tractography Open
Resolving trajectories of axonal pathways in the primate prefrontal cortex remains crucial to gain insights into higher-order processes of cognition and emotion, which requires a comprehensive map of axonal projections linking demarcated s…
View article: Bakuchiol Dimers From Psoraleae Fructus That Inhibit Nitric Oxide Production in RAW264.7 Macrophages Cells
Bakuchiol Dimers From Psoraleae Fructus That Inhibit Nitric Oxide Production in RAW264.7 Macrophages Cells Open
Background: Dried fruit of Psoralea corylifolia L. (Psoraleae Fructus) is one of the most popular traditional Chinese medicine with treatment for nephritis, spermatorrhea, pollakiuria, asthma, and various inflammatory diseases. Bakuchiol i…
View article: Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway
Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway Open
Inhibition of activated macrophages is an alternative therapeutic strategy for asthma. We investigated whether a coumarin compound, osthole, isolated from Cnidium monnieri (L.) Cuss, alleviated macrophage activation in vivo and in vitro . …
View article: The Role of Macrophage Migration Inhibitory Factor (MIF) in Asthmatic Airway Remodeling
The Role of Macrophage Migration Inhibitory Factor (MIF) in Asthmatic Airway Remodeling Open
MIF can increase asthmatic airway remodeling by enhancing ASMC autophagy. Macrophage-derived MIF can promote ASMC autophagy by targeting CD74.
View article: Radiomics models for diagnosing microvascular invasion in hepatocellular carcinoma: which model is the best model?
Radiomics models for diagnosing microvascular invasion in hepatocellular carcinoma: which model is the best model? Open
Radiomics can be used for the preoperative, noninvasive diagnosis of MVI, but different dimensionality reduction and modeling methods will affect the diagnostic performance of the final model. The model established with the LASSO+GBDT meth…
View article: Brain Map of Intrinsic Functional Flexibility in Anesthetized Monkeys and Awake Humans
Brain Map of Intrinsic Functional Flexibility in Anesthetized Monkeys and Awake Humans Open
Emerging neuroimaging studies emphasize the dynamic organization of spontaneous brain activity in both human and non-human primates, even under anesthesia. In a recent study, we were able to characterize the heterogeneous architecture of i…
View article: Dissociable Changes of Frontal and Parietal Cortices in Inherent Functional Flexibility across the Human Life Span
Dissociable Changes of Frontal and Parietal Cortices in Inherent Functional Flexibility across the Human Life Span Open
Extensive evidence suggests that frontoparietal regions can dynamically update their pattern of functional connectivity, supporting cognitive control and adaptive implementation of task demands. However, it is largely unknown whether this …
View article: Identification of Key Proteins and Networks Related to Grain Development in Wheat (Triticum aestivum L.) by Comparative Transcription and Proteomic Analysis of Allelic Variants in TaGW2-6A
Identification of Key Proteins and Networks Related to Grain Development in Wheat (Triticum aestivum L.) by Comparative Transcription and Proteomic Analysis of Allelic Variants in TaGW2-6A Open
In wheat, coding region allelic variants of TaGW2-6A are closely associated with grain width and weight, but the genetic mechanisms involved remain unclear. Thus, to obtain insights into the key functions regulated by TaGW2-6A during wheat…