Bu‐Fan Yao
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View article: 21 A first-in-human phase 1 study of SIM0417, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
21 A first-in-human phase 1 study of SIM0417, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects Open
Introduction Safe and efficacious antiviral therapeutics are in urgent need for treatment of coronavirus disease 2019. SIM0417 is a selective 3C-like protease inhibitor that can effectively inhibit severe acute respiratory syndrome coronav…
View article: 18 Use of machine learning for dosage individualization of vancomycin in neonates
18 Use of machine learning for dosage individualization of vancomycin in neonates Open
Introduction High variability in vancomycin exposure in neonates requires advanced individualized dosing regimens. Achieving steady-state trough concentration (C0) and steady-state area-under-curve (AUC0-24) targets are important to optimi…
View article: Optimal use of β-lactams in neonates: machine learning-based clinical decision support system
Optimal use of β-lactams in neonates: machine learning-based clinical decision support system Open
View article: A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects Open
Safe and efficacious antiviral therapeutics are in urgent need for the treatment of coronavirus disease 2019. Simnotrelvir is a selective 3C-like protease inhibitor that can effectively inhibit severe acute respiratory syndrome coronavirus…
View article: Developmental Population Pharmacokinetics-Pharmacodynamics of Meropenem in Chinese Neonates and Young Infants: Dosing Recommendations for Late-Onset Sepsis
Developmental Population Pharmacokinetics-Pharmacodynamics of Meropenem in Chinese Neonates and Young Infants: Dosing Recommendations for Late-Onset Sepsis Open
The pharmacokinetic (PK) studies of meropenem in Chinese newborns with late-onset sepsis (LOS) are still lacking. Causative pathogens of LOS and their susceptibility patterns in China differ from the data abroad. We, therefore, conducted a…
View article: Multi-Objective Optimization Design of Vehicle Side Crashworthiness Based on Machine Learning Point-Adding Method
Multi-Objective Optimization Design of Vehicle Side Crashworthiness Based on Machine Learning Point-Adding Method Open
Multi-objective optimization problems are often accompanied by complex black-box functions which not only increases the difficulty of solving, but also increases the solving time. In order to reduce the computational cost of solving such m…
View article: Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction
Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction Open
View article: Population Pharmacokinetic Study of Cefathiamidine in Infants With Augmented Renal Clearance
Population Pharmacokinetic Study of Cefathiamidine in Infants With Augmented Renal Clearance Open
Objectives: Augmented renal clearance (ARC) of primarily renally eliminated antibacterial agents may result in subtherapeutic antibiotic concentrations and, as a consequence, worse clinical outcomes. Cefathiamidine is frequently used as em…
View article: Developmental Population Pharmacokinetics and Dosing Optimization of Cefepime in Neonates and Young Infants
Developmental Population Pharmacokinetics and Dosing Optimization of Cefepime in Neonates and Young Infants Open
A population pharmacokinetic model of cefepime in neonates and young infants was established. According to simulation results based on the developmental pharmacokinetics-pharmacodynamics, different dosage regimens should be given depending…
View article: Aciclovir CSF concentration in children with viral encephalitis: is it adequate?
Aciclovir CSF concentration in children with viral encephalitis: is it adequate? Open