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View article: Navigating academic integrity in biomedical research: the impact of large language models on current practices and future directions
Navigating academic integrity in biomedical research: the impact of large language models on current practices and future directions Open
As Large Language Models (LLMs) continue to advance, they have garnered widespread public attention and extensive application across numerous industries and academic disciplines. The proliferation of LLMs has sparked considerable research …
View article: Tumor‐Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma (Adv. Sci. 45/2025)
Tumor‐Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma (Adv. Sci. 45/2025) Open
View article: Vascular and neurological toxicity profile of Sipuleucel-T: a large-scale real world pharmacovigilance study
Vascular and neurological toxicity profile of Sipuleucel-T: a large-scale real world pharmacovigilance study Open
Background: As the first FDA-approved autologous cellular immunotherapy, Sipuleucel-T requires comprehensive safety evaluation, particularly regarding its neurological and cardiovascular adverse effects. Methods: This study analyzed advers…
View article: Temporal evolution of large language models (LLMs) in oncology
Temporal evolution of large language models (LLMs) in oncology Open
View article: Targeting RRM2 with dual-modal theranostic smart nanoresponder overcomes osimertinib resistance and triggers immune remodeling in NSCLC
Targeting RRM2 with dual-modal theranostic smart nanoresponder overcomes osimertinib resistance and triggers immune remodeling in NSCLC Open
Osimertinib (Osi) resistance limits its efficacy in EGFR-mutant non–small cell lung cancer (NSCLC). Here, we developed a pH-responsive cationic nanovesicle ( 124 I/Cy5.5-sO@FCLs), equipped with dual-modal positron emission tomography (PET)…
View article: Editorial: The crosstalk between emerging cell death and immune microenvironment remodeling in cancer progression and treatment
Editorial: The crosstalk between emerging cell death and immune microenvironment remodeling in cancer progression and treatment Open
View article: Large language models in clinical trials: applications, technical advances, and future directions
Large language models in clinical trials: applications, technical advances, and future directions Open
This paper provides a review of LLM applications in clinical trials with an emphasis on real-world integration. Comparative advantages over traditional NLP models, technical limitations, and future implementation challenges are also discus…
View article: Inside Front Cover: Unveiling large multimodal models in pulmonary CT: A comparative assessment of generative AI performance in lung cancer diagnostics (View 5/2025)
Inside Front Cover: Unveiling large multimodal models in pulmonary CT: A comparative assessment of generative AI performance in lung cancer diagnostics (View 5/2025) Open
View article: Computational approaches to druggable site identification: Current status and future perspective
Computational approaches to druggable site identification: Current status and future perspective Open
View article: Tumor‐Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma
Tumor‐Targeted FABP5/STING Cascade Promote Radiofrequency Ablation Induced Ferroptosis and Intratumoral Immune Rewiring in Hepatocellular Carcinoma Open
Radiofrequency ablation (RFA) has emerged as a critical therapeutic modality for hepatocellular carcinoma (HCC). Biomimetic magnetic nanoparticles further augment RFA efficacy by enhancing targeting precision and biocompatibility. This stu…
View article: The Future of Cancer Therapy: Nanomaterials and Tumor Microenvironment
The Future of Cancer Therapy: Nanomaterials and Tumor Microenvironment Open
View article: Delving Into the Dialogue between Epigenetic Modifications and Immunometabolism in Cancer
Delving Into the Dialogue between Epigenetic Modifications and Immunometabolism in Cancer Open
Tumor immunometabolism and epigenetic modifications are intricately linked in reshaping the tumor microenvironment, with their crosstalk offering novel insights into cancer biology. Nutrient deprivation and metabolic byproducts drive metab…
View article: The microbiome in cancer
The microbiome in cancer Open
The human microbiome is now recognized as a central regulator of cancer biology, intricately shaping tumor development, immune dynamics, and therapeutic response. This comprehensive review delineates the multifaceted roles of bacteria, vir…
View article: RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling
RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling Open
Hepatocellular carcinoma (HCC) is associated with high mortality rates despite the widespread application of radiofrequency ablation (RFA), which has limited therapeutic efficacy as a monotherapy. This study investigated ribonucleotide red…
View article: Erratum to 'Integrating Radiosensitivity Index and Radiation Resistance Related Index Improves Prostate Cancer Outcome Prediction' [Advances in Radiation Oncology (2025) 10, 101713].
Erratum to 'Integrating Radiosensitivity Index and Radiation Resistance Related Index Improves Prostate Cancer Outcome Prediction' [Advances in Radiation Oncology (2025) 10, 101713]. Open
View article: Sequential HAIC-TACE combined with targeted and immunotherapy in hepatocellular carcinoma: a quality improvement study
Sequential HAIC-TACE combined with targeted and immunotherapy in hepatocellular carcinoma: a quality improvement study Open
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality. Emerging evidence suggests that quadruple therapy – combining hepatic artery infusion chemotherapy (HAIC), transcatheter arterial chemoembolization (TA…
View article: Bridging artificial intelligence and biological sciences: a comprehensive review of large language models in bioinformatics
Bridging artificial intelligence and biological sciences: a comprehensive review of large language models in bioinformatics Open
Large language models (LLMs), representing a breakthrough advancement in artificial intelligence, have demonstrated substantial application value and development potential in bioinformatics research, particularly showing significant progre…
View article: Evaluating the potential risks of employing large language models in peer review
Evaluating the potential risks of employing large language models in peer review Open
Objective This study aims to systematically investigate the potential harms of Large Language Models (LLMs) in the peer review process. Background LLMs are increasingly used in academic processes, including peer review. While they can addr…
View article: Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization
Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization Open
Angiogenesis is vital for tumor growth and metastasis, with tumor‐associated macrophages (TAMs) being key pro‐angiogenic cells recruited by tumor‐secreted chemokines. High levels of TAMs contribute to tumor progression and antiangiogenic t…
View article: Performance analysis of large language models in multi-disease detection from chest computed tomography reports: a comparative study
Performance analysis of large language models in multi-disease detection from chest computed tomography reports: a comparative study Open
Background: Computed tomography (CT) is widely acknowledged as the gold standard for diagnosing thoracic diseases. However, the accuracy of interpretation significantly depends on radiologists’ expertise. Large language models (LLMs) have …
View article: Unveiling large multimodal models in pulmonary CT: A comparative assessment of generative AI performance in lung cancer diagnostics
Unveiling large multimodal models in pulmonary CT: A comparative assessment of generative AI performance in lung cancer diagnostics Open
Introduction: The emerging generative artificial intelligence (Gen‐AI) is increasingly recognized for its potential in healthcare, particularly in complex radiological interpretations. However, the clinical utility of Gen‐AI requires thoro…
View article: Evaluating generative AI models for explainable pathological feature extraction in lung adenocarcinoma: grading assessment and prognostic model construction
Evaluating generative AI models for explainable pathological feature extraction in lung adenocarcinoma: grading assessment and prognostic model construction Open
Background: Given the increasing prevalence of generative AI (GenAI) models, a systematically evaluation of their performance in lung adenocarcinoma histopathological assessment is crucial. This study aimed to evaluate and compare three vi…
View article: Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation
Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation Open
Liver metastasis remains the predominant cause of mortality in patients with colorectal cancer (CRC). Nevertheless, the mechanisms underlying the initiation of colorectal cancer liver metastasis remain poorly elucidated. During the metasta…
View article: Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development
Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development Open
Intratumoral microorganisms within solid tumor TMEs significantly influence tumorigenesis and development by altering immune and metabolic patterns. Their diverse compositions and species contribute to the structural and functional heterog…
View article: Table S2 from T-cell Senescence in the Tumor Microenvironment
Table S2 from T-cell Senescence in the Tumor Microenvironment Open
Table S2 Current Clinical Trials and Approaches Targeting T-cell Senescence
View article: Data from T-cell Senescence in the Tumor Microenvironment
Data from T-cell Senescence in the Tumor Microenvironment Open
T-cell senescence occurs in the tumor microenvironment (TME) and influences cancer outcomes as well as the effectiveness of immunotherapies. The TME triggers this T-cell senescence via multiple pathways, including persistent stimulation wi…
View article: Table S1 from T-cell Senescence in the Tumor Microenvironment
Table S1 from T-cell Senescence in the Tumor Microenvironment Open
Table S1 Characteristics of Specific Phenotype of (Transitional) Senescent T cells in cancers
View article: Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst
Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst Open
The rapid advancement of multi‐omics single‐cell technologies has significantly enhanced our ability to investigate complex biological systems at unprecedented resolution. However, many existing analysis tools are complex, requiring substa…
View article: Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy
Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy Open
Small cell lung cancer (SCLC) is an extremely aggressive and highly malignant type of lung cancer that frequently develops resistance and recurrence following initial treatment. Paclitaxel (PTX) is a second‐line therapeutic option for SCLC…
View article: Multiomic traits reveal that critical irinotecan-related core regulator FSTL3 promotes CRC progression and affects ferroptosis
Multiomic traits reveal that critical irinotecan-related core regulator FSTL3 promotes CRC progression and affects ferroptosis Open