Explanipedia

Scaffold‐Based Libraries Versus Make‐on‐Demand Space: A Comparative Assessment of Chemical Content Open

Linh T. Bui, Teodora Djikić, Guillaume Bret, Frédéric Bihel, Esther Kellenberger · 2025

Chemical libraries are essential in drug discovery, providing a vast variety of compounds for screening and exploration. Previously, through collective efforts of chemoinformaticians and chemists, the group has created two libraries: the e…

Cloud-Based Clonogenics and Cell Migration Guide Nanoparticle Mediated Chemo-Radiotherapy Against Glioblastomas Open

Anne M. Hubbard, Jayce Hughes, Sara S. Strom, Hafsa A Osman, Natasha Ratnapradipa , et al. · 2025

Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor. The prognosis for patients diagnosed with GBM remains very poor with the median survival time of only 8 months if nothing is done, and 12 - 15 months if surgery, rad…

Germline and somatic genetic effects on gene expression and outcome in patients with Multiple Myeloma Open

Heini M. Natri, Linh T. Bui, Lance Peter, Bianca Argente, Arnold Federico , et al. · 2024

Multiple Myeloma (MM) is a hematological malignancy associated with poor prognosis and relapses. MM has a strong inherited component, and while the mutational and transcriptomic landscapes of MM have been characterized extensively, the mol…

Identification of COL11A1 single-gene polymorphisms in patients with primary angle-closure glaucoma Open

Bich Thuy Thi Vo, Vinh Quang Hoang, Linh T. Bui, Vinh Quang Hoang, Nhat Kim Ngan Nguyen , et al. · 2024

Introduction: According to a survey of the Rapid Assessment of Avoidable Blindness (RAAB) in Vietnam in 2015, glaucoma is the third most common cause of blindness after cataracts and fundus diseases, with a rate of 4%. Worldwide, studies o…

Integrated characterization of cell types, states and molecular programs in disseminated appendiceal neoplasms Open

Linh T. Bui, Xu Cao, Jinhui Wang, Fan Meng, Mingye Feng , et al. · 2023

Appendiceal neoplasms include a heterogeneous group of epithelial and non-epithelial tumors with varying malignant potential. Despite the rise in incidence of appendiceal neoplasms in recent years, limited progress has been made in the und…

An integrated cell atlas of the lung in health and disease Open

Lisa Sikkema, Ciro Ramírez-Suástegui, Daniel Strobl, Tessa E. Gillett, Luke Zappia , et al. · 2023

Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these lim…

Pantopaque: Does It Still Migrate With Gravity After 30 Years? Open

Frank Ma, Jamie M. Jacobs, Linh T. Bui, Antonio K Liu · 2022

Pantopaque was an oil-based positive contrast media used in central nervous system imaging before the use of water-soluble contrast agents. It is no longer used due to side effects, including arachnoiditis. Prior studies have indicated tha…

An integrated cell atlas of the human lung in health and disease Open

Malte D. Luecken, Lisa Sikkema, Daniel Strobl, Luke Zappia, Elo Madissoon , et al. · 2022

Organ- and body-scale cell atlases have the potential to transform our understanding of human biology. To capture the variability present in the population, these atlases must include diverse demographics such as age and ethnicity from bot…

Single-cell transcriptomic assessment of cellular phenotype stability in human precision-cut lung slices Open

Nichelle I. Winters, Chase J. Taylor, Christopher S. Jetter, Jane Camarata, Austin J. Gutierrez , et al. · 2021

Precision-cut lung slices (PCLS) are increasingly utilized for ex vivo disease modeling, but a high-resolution characterization of cellular phenotype stability in PCLS has not been reported. Comparing the single-cell transcriptomic profile…

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity Open

Linh T. Bui, Nichelle I. Winters, Mei-I Chung, Chitra Joseph, Austin J. Gutierrez , et al. · 2021

Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung Open

Jonas C. Schupp, Taylor Adams, Carlos Cosme, Micha Sam Brickman Raredon, Yifan Yuan , et al. · 2021

Background: Cellular diversity of the lung endothelium has not been systematically characterized in humans. We provide a reference atlas of human lung endothelial cells (ECs) to facilitate a better understanding of the phenotypic diversity…

Alveolar Basement Membrane and Transitional Cell Dynamics Identified by Single Cell RNA Sequencing Open

A. Scott McCall, AJ Gutierrez, Chase J. Taylor, Carla L. Calvi, Nichelle I. Winters , et al. · 2021

Rationale: Development of the alveolar basement membrane (ABM) is crucial for alveolar gas-exchange and normal pulmonary function, and its repair is critical for restoration of lung function following acute or chronic lung injury.There is …

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics Open

Christoph Muus, Malte D. Luecken, Gökcen Eraslan, Lisa Sikkema, Avinash Waghray , et al. · 2021

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact a…

ILD_alldataset_population_noSCT.rds Open

Austin J. Gutierrez, Linh T. Bui · 2021

Single Cell mRNA Sequencing Seurat Object from diseased human lung samples

Sample_metadata_information.csv Open

Austin J. Gutierrez, Linh T. Bui · 2021

Metadata file for corresponding seurat object at "https://figshare.com/articles/dataset/ILD_alldataset_population_noSCT_rds/16653148"

ILD_meta.data_nodoublets.csv Open

Austin J. Gutierrez, Linh T. Bui · 2021

Metadata file for corresponding seurat object at "https://figshare.com/articles/dataset/ILD_alldataset_population_noSCT_rds/16653148"

27‐Hydroxycholesterol regulates human <i>SLC22A12</i> gene expression through estrogen receptor action Open

Masaya Matsubayashi, Yoshihiko Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi , et al. · 2020

The excretion and reabsorption of uric acid both to and from urine are tightly regulated by uric acid transporters. Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the …

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity Open

Linh T. Bui, Nichelle I. Winters, Mei-I Chung, Chitra Joseph, Austin J. Gutierrez , et al. · 2020

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyzed the transcriptomes of 605,904 single cells isolated from healthy and CLD lungs to identify mo…

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung Open

Jonas C. Schupp, Taylor Adams, Carlos Cosme, Micha Sam Brickman Raredon, Norihito Omote , et al. · 2020

Background Despite its importance in health and disease, the cellular diversity of the lung endothelium has not been systematically characterized in humans. Here we provide a reference atlas of human lung endothelial cells (ECs), to facili…

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity Open

Linh T. Bui, Nichelle I. Winters, Mei-I Chung, Chitra Joseph, Austin J. Gutierrez , et al. · 2020

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyzed the transcriptomes of 605,904 single cells isolated from healthy and CLD lungs to identify mo…

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis Open

Arun C. Habermann, Austin J. Gutierrez, Linh T. Bui, Stephanie L. Yahn, Nichelle I. Winters , et al. · 2020

Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.

Single-Cell RNA Sequencing Identifies a Novel Profibrotic Epithelial Cell Population in Pulmonary Fibrosis Open

Mei-I Chung, Annett Habermann, Austin J. Gutierrez, Linh T. Bui, Stephanie L. Yahn , et al. · 2020

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells Open

Christoph Muus, Malte D. Luecken, Gökcen Eraslan, Avinash Waghray, Graham Heimberg , et al. · 2020

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2…

SUN-590 27-Hydroxycholesterol Triggers the Whitening of Brown Adipose Tissue Open

Arvand Asghari, Linh T. Bui, Robert Stephen, Michihisa Umetani · 2020

27-Hydroxycholesterol (27HC) is the most abundant oxysterol in circulation and metabolized by a P450 enzyme CYP7B1. Its levels closely correspond to those of cholesterol in the body. In addition, previously it was found that 27HC is an end…

Human URAT1/<i>SLC22A12</i>gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements Open

Masaya Matsubayashi, Yoshihiko Sakaguchi, Yoshiki Sahara, Hitoki Nanaura, Sotaro Kikuchi , et al. · 2019

Elevated levels of uric acid, a metabolite of purine in humans, is related to various diseases, such as gout, atherosclerosis and renal dysfunction. The excretion and reabsorption of uric acid to/from urine is tightly regulated by uric aci…

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis Open

Arun C. Habermann, Austin J. Gutierrez, Linh T. Bui, Stephanie L. Yahn, Nichelle I. Winters , et al. · 2019

Pulmonary fibrosis is a form of chronic lung disease characterized by pathologic epithelial remodeling and accumulation of extracellular matrix. In order to comprehensively define the cell types, mechanisms and mediators driving fibrotic r…

27-Hydroxycholesterol Promotes Adiposity and Mimics Adipogenic Diet-Induced Inflammatory Signaling Open

Arvand Asghari, Tomonori Ishikawa, Shiro Hiramitsu, Wan-Ru Lee, Junko Umetani , et al. · 2019

27-Hydroxycholesterol (27HC) is an abundant cholesterol metabolite and has detrimental effects on the cardiovascular system, whereas its impact on adiposity is not well known. In this study, we found that elevations in 27HC cause increased…

Multiple Plasticity Regulators Reveal Targets Specifying an Induced Predatory Form in Nematodes Open

Linh T. Bui, Erik J. Ragsdale · 2019

The ability to translate a single genome into multiple phenotypes, or developmental plasticity, defines how phenotype derives from more than just genes. However, to study the evolutionary targets of plasticity and their evolutionary fates,…

Author Correction: A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus Open

Linh T. Bui, Nicholas A. Ivers, Erik J. Ragsdale · 2018

The original version of this Article contained errors in Figure 4. In panel a, the x axis labels of bars 6-11 were incorrect, as depicted in the associated Author Correction. These errors have been corrected in both the PDF and HTML versio…

A sulfotransferase dosage-dependently regulates mouthpart polyphenism in the nematode Pristionchus pacificus Open

Linh T. Bui, Nicholas A. Ivers, Erik J. Ragsdale · 2018

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