Bumsoo Ahn
YOU?
Author Swipe
View article: Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy
Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy Open
Chaperone-mediated autophagy (CMA) contributes to proteostasis maintenance by selectively degrading a subset of proteins in lysosomes. CMA declines with age in most tissues, including skeletal muscle. However, the role of CMA in skeletal m…
View article: Mitochondrial bioenergetics in resilience of older adults with gynecologic cancer: design and rationale of a pilot study
Mitochondrial bioenergetics in resilience of older adults with gynecologic cancer: design and rationale of a pilot study Open
Resilience—the ability to recover and maintain function following stresses—is a critical factor influencing treatment tolerance and recovery in older adults with cancer. Despite the high incidence of gynecologic cancers in postmenopausal i…
View article: Mitochondrial Bioenergetics in Resilience of Older Adults with Gynecologic Cancer: Design and Rationale of a Pilot Study
Mitochondrial Bioenergetics in Resilience of Older Adults with Gynecologic Cancer: Design and Rationale of a Pilot Study Open
Resilience, the ability to recover and maintain function following stresses, is a critical factor influencing treatment tolerance and recovery in older adults with cancer. Despite the high incidence of gynecologic cancers in postmenopausal…
View article: Mitochondrial haplotype and sex modulate responses to endurance exercise training
Mitochondrial haplotype and sex modulate responses to endurance exercise training Open
Heterogeneity in the response to exercise training is widely demonstrated in the literature. Although the variability in exercise acclimation is not entirely understood, a large portion of exercise response variability is attributable to g…
View article: Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia
Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia Open
Background Cancer cachexia is a complex metabolic syndrome that severely impacts patient mobility, treatment strategies, and quality of life. However, no treatments are available to mitigate the debilitating consequences of cancer cachexia…
View article: Unacylated Ghrelin Protects Against Age‐Related Loss of Muscle Mass and Contractile Dysfunction in Skeletal Muscle
Unacylated Ghrelin Protects Against Age‐Related Loss of Muscle Mass and Contractile Dysfunction in Skeletal Muscle Open
Sarcopenia, the progressive loss of muscle mass and function, universally affects older adults and is closely associated with frailty and reduced quality of life. Despite the inevitable consequences of sarcopenia and its relevance to healt…
View article: mitochodnrial assays in human muscle biopsies v1
mitochodnrial assays in human muscle biopsies v1 Open
This protocol simultaneously measures mitochondrial respiration and hydrogen peroxide generation rates in human muscle biopsy tissues. The protocol also includes methods for measurement of mitochondrial sensitivity to ADP and responses to …
View article: Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation
Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation Open
Objectives: To test whether mitochondrial transplantation (MITO) mitigates damage in 2 models of acute kidney injury (AKI). Background: MITO is a process where exogenous isolated mitochondria are taken up by cells. As virtually any morbid …
View article: A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes
A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes Open
We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide investigators with a highly genetically diverse rat m…
View article: Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione
Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione Open
Neurotoxic regimens of methamphetamine (METH) are known to increase reactive oxygen species (ROS), affect redox homeostasis, and lead to damage in dopamine neurons. Functional changes induced by long-term METH self-administration on mitoch…
View article: Acylated Ghrelin Receptor Agonist HM01 Decreases Lean Body and Muscle Mass, but Unacylated Ghrelin Protects against Redox-Dependent Sarcopenia
Acylated Ghrelin Receptor Agonist HM01 Decreases Lean Body and Muscle Mass, but Unacylated Ghrelin Protects against Redox-Dependent Sarcopenia Open
Sarcopenia, the progressive loss of muscle mass and dysfunction, universally affects the elderly and is closely associated with frailty and reduced quality of life. Despite the inevitable consequences of sarcopenia and its relevance to hea…
View article: Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation
Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation Open
Muscle weakness associated with sarcopenia is a major contributor to reduced health span and quality of life in the elderly. However, the underlying mechanisms of muscle weakness in aging are not fully defined. We investigated the effect o…
View article: Methamphetamine Self-Administration Differential Effects on Mesolimbic Glutathione Levels, Mitochondrial Respiration and Dopamine Neuron Firing Activity
Methamphetamine Self-Administration Differential Effects on Mesolimbic Glutathione Levels, Mitochondrial Respiration and Dopamine Neuron Firing Activity Open
Acute and neurotoxic regimens of METH are known to increase reactive oxygen species (ROS), affect redox homeostasis, and lead to cellular damage in dopamine neurons. However, functional changes induced by long-term METH self-administration…
View article: Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia
Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia Open
Age‐related muscle atrophy and weakness, or sarcopenia, are significant contributors to compromised health and quality of life in the elderly. While the mechanisms driving this pathology are not fully defined, reactive oxygen species, neur…
View article: Myocardial Hypertrophy and Compensatory Increase in Systolic Function in a Mouse Model of Oxidative Stress
Myocardial Hypertrophy and Compensatory Increase in Systolic Function in a Mouse Model of Oxidative Stress Open
Free radicals, or reactive oxygen species, have been implicated as one of the primary causes of myocardial pathologies elicited by chronic diseases and age. The imbalance between pro-oxidants and antioxidants, termed “oxidative stress”, in…
View article: Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice
Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice Open
Sarcopenia has a significant negative impact on healthspan in the elderly and effective pharmacologic interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic ret…
View article: Comparative Efficacy of Angiotensin II Type 1 Receptor Blockers Against Ventilator‐Induced Diaphragm Dysfunction in Rats
Comparative Efficacy of Angiotensin II Type 1 Receptor Blockers Against Ventilator‐Induced Diaphragm Dysfunction in Rats Open
Mechanical ventilation (MV) is a life‐saving intervention for many critically ill patients. Unfortunately, prolonged MV results in the rapid development of inspiratory muscle weakness due to diaphragmatic atrophy and contractile dysfunctio…
View article: Cancer cachexia in a mouse model of oxidative stress
Cancer cachexia in a mouse model of oxidative stress Open
Background Cancer is associated with muscle atrophy (cancer cachexia) that is linked to up to 40% of cancer‐related deaths. Oxidative stress is a critical player in the induction and progression of age‐related loss of muscle mass and weakn…
View article: Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice
Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice Open
Age‐associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice ( Sod1 −/− mice) recapitulates sarcopenia phenotypes, includi…
View article: Mitochondrial physiology
Mitochondrial physiology Open
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent…
View article: Mitochondrial Physiology
Mitochondrial Physiology Open
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent…
View article: Changes of Aerobic Fitness and Cardiovascular Disease Risk Factors in Children over Two Years
Changes of Aerobic Fitness and Cardiovascular Disease Risk Factors in Children over Two Years Open
This study examined the relationship between two-year changes of aerobic fitness and cardiovascular disease (CVD) risk factors in children. Baseline and follow-up data were obtained from 120 children, the CHIC III Study. Aerobic fitness wa…
View article: Effects of exercise preconditioning and HSP72 on diaphragm muscle function during mechanical ventilation
Effects of exercise preconditioning and HSP72 on diaphragm muscle function during mechanical ventilation Open
Background Mechanical ventilation (MV) is a life‐saving measure for patients in respiratory failure. However, prolonged MV results in significant diaphragm atrophy and contractile dysfunction, a condition referred to as ventilator‐induced …
View article: Neuroprotective effects of PPARα in retinopathy of type 1 diabetes
Neuroprotective effects of PPARα in retinopathy of type 1 diabetes Open
Diabetic retinopathy (DR) is a common neurovascular complication of type 1 diabetes. Current therapeutics target neovascularization characteristic of end-stage disease, but are associated with significant adverse effects. Targeting early e…
View article: Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching Open
Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology …
View article: Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction
Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction Open
Heart failure with reduced ejection fraction (HFREF) increases neutral sphingomyelinase (NSMase) activity and mitochondrial reactive oxygen species (ROS) emission and causes diaphragm weakness. We tested whether a systemic pharmacological …
View article: Mitochondrial respiratory states and rates
Mitochondrial respiratory states and rates Open
As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmoti…