Burkhardt Flemer
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View article: Cover Image, Volume 45, Issue 7
Cover Image, Volume 45, Issue 7 Open
The cover image is based on the article Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis by Felix Sommer et al…
View article: Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis
Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis Open
View article: Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in mice
Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in mice Open
Background A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation, namely the “Warburg effect”, represents a hallmark of cancer cells. Hexokinases (HK) catalyze the first step of glycolysis, thereby regulating its ra…
View article: Biotic and Abiotic Stress Factors Induce Microbiome Shifts and Enrichment of Distinct Beneficial Bacteria in Tomato Roots
Biotic and Abiotic Stress Factors Induce Microbiome Shifts and Enrichment of Distinct Beneficial Bacteria in Tomato Roots Open
Crops are often simultaneously threatened by abiotic and biotic stress factors but the stress response of the plant holobiont is not well understood, despite the high importance of this response to ensure future plant production. Therefore…
View article: Transcriptional Changes in Potato Sprouts upon Interaction with Rhizoctonia solani Indicate Pathogen-Induced Interference in the Defence Pathways of Potato
Transcriptional Changes in Potato Sprouts upon Interaction with Rhizoctonia solani Indicate Pathogen-Induced Interference in the Defence Pathways of Potato Open
Rhizoctonia solani is the causer of black scurf disease on potatoes and is responsible for high economical losses in global agriculture. In order to increase the limited knowledge of the plants’ molecular response to this pathogen, we inoc…
View article: Fiber-associated<i>Lachnospiraceae</i>reduce colon tumorigenesis by modulation of the tumor-immune microenvironment
Fiber-associated<i>Lachnospiraceae</i>reduce colon tumorigenesis by modulation of the tumor-immune microenvironment Open
Patients with colorectal cancer (CRC) harbor gut microbiomes that differ in structure and function from those of healthy individuals, suggesting this altered microbiome could contribute to tumorigenesis. Despite increasing evidence implica…
View article: Fiber-Associated Lachnospiraceae Reduce Colon Tumorigenesis by Modulation of the Tumor-Immune Microenvironment
Fiber-Associated Lachnospiraceae Reduce Colon Tumorigenesis by Modulation of the Tumor-Immune Microenvironment Open
View article: Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation
Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation Open
Homeostatic interactions with the microbiome are central for a healthy human physiology and nutrition is the main driving force shaping the microbiome. In the past decade, a wealth of preclinical studies mainly using gnotobiotic animal mod…
View article: Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease
Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease Open
View article: Salmonella Establishment in Agricultural Soil and Colonization of Crop Plants Depend on Soil Type and Plant Species
Salmonella Establishment in Agricultural Soil and Colonization of Crop Plants Depend on Soil Type and Plant Species Open
Human pathogenic bacteria, such as Salmonella enterica, are able to colonize crop plants. So far, not much is known about biotic and abiotic factors influencing this colonization in field soil. This understanding, however, is impera…
View article: Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection
Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Open
View article: Tumour-associated and non-tumour-associated microbiota: Addendum
Tumour-associated and non-tumour-associated microbiota: Addendum Open
In a recent study1 we reported that tissue-associated microbial Co-abundance Groups (CAGs) were differentially associated with colorectal cancer (CRC). Two of the CAGs, which we named Pathogen CAG and Prevotella CAG, were correl…
View article: Additional file 3: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection
Additional file 3: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Open
Table S7. Genes associated with archaeal metabolism obtained from shotgun metagenomic sequencing (XLS 24Â kb)
View article: Additional file 2: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection
Additional file 2: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Open
Table S6. Taxonomic count of shotgun data for this study. (XLSX 19Â kb)
View article: The oral microbiota in colorectal cancer is distinctive and predictive
The oral microbiota in colorectal cancer is distinctive and predictive Open
Background and aims Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally deri…
View article: Fecal microbiota variation across the lifespan of the healthy laboratory rat
Fecal microbiota variation across the lifespan of the healthy laboratory rat Open
Laboratory rats are commonly used in life science research as a model for human biology and disease, but the composition and development of their gut microbiota during life is poorly understood. We determined the fecal microbiota compositi…
View article: Tumour-associated and non-tumour-associated microbiota in colorectal cancer
Tumour-associated and non-tumour-associated microbiota in colorectal cancer Open
Objective: A signature that unifies the colorectal cancer (CRC) microbiota across multiple studies has not been identified. In addition to methodological variance, heterogeneity may be caused by both microbial and host response differences…