David M. Burmeister
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View article: User experience and hemostatic efficacy: Comparative analysis of commercial agents in junctional and hepatic hemorrhage models
User experience and hemostatic efficacy: Comparative analysis of commercial agents in junctional and hepatic hemorrhage models Open
Background/Objectives Hemorrhage is associated with most preventable combat-related deaths. Management of non-compressible truncal and junctional hemorrhage remains challenging, especially with prolonged evacuations. This study evaluated t…
View article: Abscopal Brain Proteomic Changes Associated with Microbiome Alterations Induced by Gastrointestinal Acute Radiation Syndrome in Swine
Abscopal Brain Proteomic Changes Associated with Microbiome Alterations Induced by Gastrointestinal Acute Radiation Syndrome in Swine Open
Emerging research highlights the gut microbiota’s critical role in modulating brain activity via the gut–brain axis. This study explores whether targeted gastrointestinal irradiation induces abscopal effects on the brain proteome, revealin…
View article: Pilot Study on Resuscitation Volume’s Effect on Perfusion and Inflammatory Cytokine Expression in Peri-Burn Skin: Implications for Burn Conversion
Pilot Study on Resuscitation Volume’s Effect on Perfusion and Inflammatory Cytokine Expression in Peri-Burn Skin: Implications for Burn Conversion Open
Fluid resuscitation after thermal injury is paramount to avoid burn shock and restore organ perfusion. Both over- and under-resuscitation can lead to unintended consequences affecting patient outcomes. While many studies have examined syst…
View article: Novel silica-based polymer hemostatic matrix improves vessel patency rates in a coagulopathic porcine model with penetrating arterial injury
Novel silica-based polymer hemostatic matrix improves vessel patency rates in a coagulopathic porcine model with penetrating arterial injury Open
BACKGROUND Traumatic hemorrhage is the leading cause of preventable battlefield death and hemostatic agents can improve survival. We compared a novel, amorphous, silica dioxide–based fiber (SBF) hemostatic matrix to the criterion standard …
View article: 511 Gastrointestinal Acute Radiation Syndrome Delays Epithelialization of Thermal Burn Wounds in Swine
511 Gastrointestinal Acute Radiation Syndrome Delays Epithelialization of Thermal Burn Wounds in Swine Open
Introduction The current geopolitical climate increases the likelihood of nuclear attacks which would cause complex injuries such as concomitant thermal burns and radiation exposure (i.e., combined injury). Combined injuries are not comple…
View article: The Incidence of Volatile Anesthesia Porcine Stress Syndrome in Pigs (Sus scrofa domesticus) Gives Implications for Physiology during Anesthesia
The Incidence of Volatile Anesthesia Porcine Stress Syndrome in Pigs (Sus scrofa domesticus) Gives Implications for Physiology during Anesthesia Open
Pigs are extensively used for biomedical research as animal models given their similarities to humans including size, arterial capacity, and cutaneous structure. While their size also allows for the use of clinically available anesthesia e…
View article: A mathematical model for simulation of cardiovascular, renal, and hormonal responses to burn injury and resuscitation
A mathematical model for simulation of cardiovascular, renal, and hormonal responses to burn injury and resuscitation Open
Introduction Treating extensive burn injury requires an individually tailored resuscitation protocol that includes hourly-titrated intravenous fluid infusion to avert both hypovolemic shock and edema. Due to the complexity of burn pathophy…
View article: Canagliflozin Mitigates Acute Kidney Injury Secondary to Resuscitative Endovascular Balloon Occlusion of the Aorta in a Porcine Model of Hemorrhagic Shock
Canagliflozin Mitigates Acute Kidney Injury Secondary to Resuscitative Endovascular Balloon Occlusion of the Aorta in a Porcine Model of Hemorrhagic Shock Open
Objective: We investigated the potential of acute canagliflozin administration to mitigate acute kidney injury (AKI) and attenuate deleterious pro-inflammatory cytokine release in a clinically relevant swine model of severe renal ischemia …
View article: MICROBIOME AND INFLAMMASOME ALTERATIONS FOUND DURING RADIATION DOSE FINDING IN A SINCLAIR MINIPIG MODEL OF GASTROINTESTINAL ACUTE RADIATION SYNDROME
MICROBIOME AND INFLAMMASOME ALTERATIONS FOUND DURING RADIATION DOSE FINDING IN A SINCLAIR MINIPIG MODEL OF GASTROINTESTINAL ACUTE RADIATION SYNDROME Open
Both abdominal radiotherapy and a nuclear event can result in gastrointestinal symptoms, including acute radiation syndrome (GI-ARS). GI-ARS is characterized by compromised intestinal barrier integrity increasing the risk for infectious co…
View article: Initial Development and Analysis of a Context-Aware Burn Resuscitation Decision-Support Algorithm
Initial Development and Analysis of a Context-Aware Burn Resuscitation Decision-Support Algorithm Open
Burn patients require high-volume intravenous resuscitation with the goal of restoring global tissue perfusion to make up for burn-induced loss of fluid from the vasculature. Clinical standards of burn resuscitation are predominantly based…
View article: Effects of combined ciprofloxacin and Neulasta therapy on intestinal pathology and gut microbiota after high-dose irradiation in mice
Effects of combined ciprofloxacin and Neulasta therapy on intestinal pathology and gut microbiota after high-dose irradiation in mice Open
Introduction Treatments that currently exist in the strategic national stockpile for acute radiation syndrome (ARS) focus on the hematopoietic subsyndrome, with no treatments on gastrointestinal (GI)-ARS. While the gut microbiota helps mai…
View article: Ferroptosis, Inflammation, and Microbiome Alterations in the Intestine in the Göttingen Minipig Model of Hematopoietic-Acute Radiation Syndrome
Ferroptosis, Inflammation, and Microbiome Alterations in the Intestine in the Göttingen Minipig Model of Hematopoietic-Acute Radiation Syndrome Open
Hematopoietic acute radiation syndrome (H-ARS) involves injury to multiple organ systems following total body irradiation (TBI). Our laboratory demonstrated that captopril, an angiotensin-converting enzyme inhibitor, mitigates H-ARS in Göt…
View article: 17 Fluid Resuscitation Effects Endothelial Glycocalyx Shedding in a Swine Model of Severe Burn Injury
17 Fluid Resuscitation Effects Endothelial Glycocalyx Shedding in a Swine Model of Severe Burn Injury Open
Introduction Severe burn injury is associated with altered hemodynamics and inflammation that can lead to reduced organ perfusion with subsequent organ dysfunction. While this may be mitigated with aggressive IV fluid administration, both …
View article: Review of machine learning for optical imaging of burn wound severity assessment
Review of machine learning for optical imaging of burn wound severity assessment Open
The field would benefit from systematic analysis of the effects of different input data modalities, training/testing sets, and ML classifiers on the reported accuracy. Despite this current limitation, ML-based algorithms show significant p…
View article: A clinically-relevant mouse model that displays hemorrhage exacerbates tourniquet-induced acute kidney injury
A clinically-relevant mouse model that displays hemorrhage exacerbates tourniquet-induced acute kidney injury Open
Hemorrhage is a leading cause of death in trauma. Tourniquets are effective at controlling extremity hemorrhage and have saved lives. However, tourniquets can cause ischemia reperfusion injury of limbs, leading to systemic inflammation and…
View article: Real-Time Measurements of Oral Mucosal Carbon Dioxide (POMCO2) Reveals an Inverse Correlation With Blood Pressure in a Porcine Model of Coagulopathic Junctional Hemorrhage
Real-Time Measurements of Oral Mucosal Carbon Dioxide (POMCO2) Reveals an Inverse Correlation With Blood Pressure in a Porcine Model of Coagulopathic Junctional Hemorrhage Open
Introduction Shock states that occur during, for example, profound hemorrhage can cause global tissue hypoperfusion leading to organ failure. There is an unmet need for a reliable marker of tissue perfusion during hemorrhage that can be fo…
View article: A Novel Sutureless Anastomotic Device in a Swine Model: A Proof of Concept Study
A Novel Sutureless Anastomotic Device in a Swine Model: A Proof of Concept Study Open
View article: Meta-Analysis of Publicly Available Clinical and Preclinical Microbiome Data From Studies of Burn Injury
Meta-Analysis of Publicly Available Clinical and Preclinical Microbiome Data From Studies of Burn Injury Open
Following burn injury, alterations in host commensal microbiota across body spaces may leave patients susceptible to opportunistic pathogens and serious sequelae such as sepsis. Generally, studies examining the microbiome postburn have had…
View article: Evaluation of novel hemostatic agents in a coagulopathic swine model of junctional hemorrhage
Evaluation of novel hemostatic agents in a coagulopathic swine model of junctional hemorrhage Open
BACKGROUND Hemostatic dressings are used extensively in both military and civilian trauma to control lethal noncompressible hemorrhage. The ideal topical hemostatic agent would provide reliable hemostasis in patients with profound acidosis…
View article: 107 Meta-Analysis of Clinical and Preclinical Microbiome Data from Studies of Burn Injury
107 Meta-Analysis of Clinical and Preclinical Microbiome Data from Studies of Burn Injury Open
Introduction Following burn injury, the ecology of the host microbiota is disrupted to varying degrees and may leave the patient susceptible to opportunistic pathogens or disrupt the endogenous flora needed to potentiate recovery and homeo…
View article: 102 Longitudinal Changes in Lingual and Intestinal Microbiota in a Swine Burn Model
102 Longitudinal Changes in Lingual and Intestinal Microbiota in a Swine Burn Model Open
Introduction Burn injury causes a complex pathophysiology resulting in morbidity and mortality often characterized by the development of infectious complications. In health, the microbiota is crucial in host homeostasis and provides numero…
View article: 103 Analysis of Arterial Blood Pressure Waveform Features in a Porcine Model of Burn and Resuscitation
103 Analysis of Arterial Blood Pressure Waveform Features in a Porcine Model of Burn and Resuscitation Open
Introduction Functional arterial blood pressure waveform (ABW) features are incompletely understood in the context of burn injury and resuscitation. In this work, we analyzed the variability of pulse pressure (PPV), systolic pressure (SPV)…
View article: 76 Resuscitation Volumes Affect Perfusion and Inflammatory Cytokine Expression in Peri-Burn Skin: Implications for Burn Conversion
76 Resuscitation Volumes Affect Perfusion and Inflammatory Cytokine Expression in Peri-Burn Skin: Implications for Burn Conversion Open
Introduction Fluid resuscitation after thermal injury is paramount to avoiding the effects of burn shock and restoring organ perfusion. Both over and under resuscitation can lead to unintended consequences affecting patient outcomes. While…
View article: On the non-bonding valence band and the electronic properties of poly(triazine imide), a graphitic carbon nitride
On the non-bonding valence band and the electronic properties of poly(triazine imide), a graphitic carbon nitride Open
PTI nano-crystals have quenched electroluminescence. Disorder at crystal interfaces limits charge transport in PTI films. For future device applications, single crystal devices using electron transport in the lowest conduction band show pr…
View article: DIAGNOSTIC VALUE OF MITOCHONDRIAL DNA AND PERIPHERAL BLOOD MONONUCLEAR CELL RESPIROMETRY FOR BURN-RELATED SEPSIS
DIAGNOSTIC VALUE OF MITOCHONDRIAL DNA AND PERIPHERAL BLOOD MONONUCLEAR CELL RESPIROMETRY FOR BURN-RELATED SEPSIS Open
Background: Sepsis is the leading cause of mortality among burn patients that survive acute resuscitation. Clinical criteria have poor diagnostic value for burn-induced sepsis, making it difficult to diagnose. Protein biomarkers (e.g., pro…
View article: Sulfur- and boron-containing porous donor-acceptor polymers for photocatalytic hydrogen evolution
Sulfur- and boron-containing porous donor-acceptor polymers for photocatalytic hydrogen evolution Open
Photocatalytic water-splitting provides a way to store solar energy as hydrogen gas, and hence, is an attractive alternative to energy-intensive electrolysis of water. Microporous polymer networks are an interesting class of heterogeneous …
View article: The Potential of Arterial Pulse Wave Analysis in Burn Resuscitation: A Pilot In Vivo Study
The Potential of Arterial Pulse Wave Analysis in Burn Resuscitation: A Pilot In Vivo Study Open
While urinary output (UOP) remains the primary endpoint for titration of intravenous fluid resuscitation, it is an insufficient indicator of fluid responsiveness. Although advanced hemodynamic monitoring (including arterial pulse wave anal…
View article: Advantages and Disadvantages of Using Small and Large Animals in Burn Research: Proceedings of the 2021 Research Special Interest Group
Advantages and Disadvantages of Using Small and Large Animals in Burn Research: Proceedings of the 2021 Research Special Interest Group Open
Multiple animal species and approaches have been used for modeling different aspects of burn care, with some strategies considered more appropriate or translatable than others. On April 15, 2021, the Research Special Interest Group of the …
View article: Front Cover: One‐pot synthesis of high‐capacity silicon anodes via on‐copper growth of a semiconducting, porous polymer
Front Cover: One‐pot synthesis of high‐capacity silicon anodes via on‐copper growth of a semiconducting, porous polymer Open
Energy coverage In cover article ntls.20210105, Michael Bojdys et al. introduce a semi-conducting porous organic polymer network, replacing all conventional additives in Si-Li anodes and enabling the one-pot production of moreperformant, f…
View article: 97 Arterial Waveform Variations as Measures of Resuscitation Adequacy in a Porcine Model of Burn Injury
97 Arterial Waveform Variations as Measures of Resuscitation Adequacy in a Porcine Model of Burn Injury Open
Introduction Optimized fluid resuscitation of burn patients is a clinical care challenge as both under- and over- resuscitation have deleterious consequences. The gold-standard endpoint guiding burn resuscitation is urinary output (UO), wh…