Bushra Ijaz
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View article: Knowledge and Practices of Breast Self-Examination among Female Students of Bahria University of Health Sciences Karachi
Knowledge and Practices of Breast Self-Examination among Female Students of Bahria University of Health Sciences Karachi Open
Breast Self-Examination is an efficient approach for investigating physical and visual abnormalities in breast tissue. Objective: To evaluate the awareness, knowledge, practice of breast self-examination among female university students in…
View article: Cytoprotective Role of Chondrocyte Coculturing for Enhanced Cartilage Regeneration
Cytoprotective Role of Chondrocyte Coculturing for Enhanced Cartilage Regeneration Open
Osteoarthritis is characterized by the progressive deterioration of articular cartilage, leading to joint pain and functional impairments. Current treatment options are limited in their ability to stimulate cartilage regeneration. Evidence…
View article: Eco-smart biocontrol strategies utilizing potent microbes for sustainable management of phytopathogenic diseases
Eco-smart biocontrol strategies utilizing potent microbes for sustainable management of phytopathogenic diseases Open
View article: Exploring Sleep Hygiene Practices and Their Relation to Sleep Quality among Medical Students at Nishtar Medical University Multan
Exploring Sleep Hygiene Practices and Their Relation to Sleep Quality among Medical Students at Nishtar Medical University Multan Open
Background: Sleep quality is particularly important for medical students who often face demanding schedules, high stress levels and an atypical sleep pattern. Objective: To evaluate subjective sleep quality among medical students and its a…
View article: Anemia and its associated factors in children aged 2-5 years in slum area of Multan.
Anemia and its associated factors in children aged 2-5 years in slum area of Multan. Open
Objective: To determine the prevalence of anemia among children aged 2-5 years in slum area of Multan and also to detect the associated factors of this condition. Study Design: Descriptive Cross Sectional Study. Setting: Slum Area (Jahangi…
View article: ANTIVIRAL SCREENING OF AZADIRACHTA INDICA PHYTOCHEMICALS AS DENGUE NS5 INHIBITOR: A MOLECULAR DOCKING APPROACH
ANTIVIRAL SCREENING OF AZADIRACHTA INDICA PHYTOCHEMICALS AS DENGUE NS5 INHIBITOR: A MOLECULAR DOCKING APPROACH Open
Dengue has been an alarming viral infection in tropical and subtropical regions of the world for the past few decades, resulting in millions of deaths. There is no effective drug to treat this arbovirus-based infection. Dengue virus non-st…
View article: Prevalence of BRCA1 and BRCA2 germline variants in an unselected pancreatic cancer patient cohort in Pakistan
Prevalence of BRCA1 and BRCA2 germline variants in an unselected pancreatic cancer patient cohort in Pakistan Open
View article: Evaluation of betanin-encapsulated biopolymeric nanoparticles for antitumor activity via PI3K/Akt/mTOR signaling pathway
Evaluation of betanin-encapsulated biopolymeric nanoparticles for antitumor activity via PI3K/Akt/mTOR signaling pathway Open
Cancer nanotheranostic components are useful in monitoring drug delivery and potency against tumor cells. Current chemotherapeutic agents exhibit severe side effects and requires the urgency for discovery of potent therapeutic nano-drugs. …
View article: PATTERN AND BURDEN OF VARIOUS MYTHS REGARDING POLIO VACCINE AMONG THE PARENTS OR LEGAL GUARDIANS WHO REFUSED POLIO VACCINATION TO THEIR CHILD
PATTERN AND BURDEN OF VARIOUS MYTHS REGARDING POLIO VACCINE AMONG THE PARENTS OR LEGAL GUARDIANS WHO REFUSED POLIO VACCINATION TO THEIR CHILD Open
Polio is still prevalent worldwide and is yet to be eradicated from Pakistan despite the best efforts of various national and international organizations such as WHO, UNICEF, and UNESCO. A study was conducted to determine the different myt…
View article: Polymeric complex nanocarriers of Mangifera indica gum & chitosan for methotrexate delivery: Formulation, characterization, and in vitro toxicological assessment
Polymeric complex nanocarriers of Mangifera indica gum & chitosan for methotrexate delivery: Formulation, characterization, and in vitro toxicological assessment Open
Methotrexate (MTX), a widely used chemotherapeutic drug, exhibits significant potential in the treatment of various solid tumors and hematologic malignancies. However, its therapeutic efficacy is often hampered by suboptimal pharmacokineti…
View article: IN SILICO SCREENING OF COMPOUNDS DERIVED FROM TECTONA GRANDIS LEAVES AGAINST COVID-19 NSP12 AND NSP15 THROUGH MOLECULAR DOCKING APPROACH
IN SILICO SCREENING OF COMPOUNDS DERIVED FROM TECTONA GRANDIS LEAVES AGAINST COVID-19 NSP12 AND NSP15 THROUGH MOLECULAR DOCKING APPROACH Open
The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) has caused immense unrest in the world. The emerging pathogenic viral strains and increasing numbers of victims demand rapid and efficient therapeutic regimens to be in…
View article: Anticancer genes (NOXA, PAR-4, TRAIL) are de-regulated in breast cancer patients and can be targeted by using a ribosomal inactivating plant protein (riproximin)
Anticancer genes (NOXA, PAR-4, TRAIL) are de-regulated in breast cancer patients and can be targeted by using a ribosomal inactivating plant protein (riproximin) Open
Background: Anticancer genes are endogenous enemies of transformed cells and impose antineoplastic effects upon ectopic expression. Identifying the expression profile of these genes is a prerequisite to explore their prognostic and therape…
View article: Rose and eucalyptus essential oil as potent anti-liver cancer agents
Rose and eucalyptus essential oil as potent anti-liver cancer agents Open
The present study was designed to investigate the anti-cancer potential of essential oil obtained from Rosa indica (REO) and Eucalyptus citriodora (EEO) against the liver carcinoma cell line (HepG2).Firstly, the cytotoxic activity was asse…
View article: S-ALLYL-L-CYSTEINE-INDUCED ANTI-INFLAMMATORY AND ANTI-APOPTOTIC EFFECTS IN CHONDROCYTES IS ASSOCIATED WITH SUPPRESSION OF THE MITOCHONDRIAL INFLAMMATION PATHWAY
S-ALLYL-L-CYSTEINE-INDUCED ANTI-INFLAMMATORY AND ANTI-APOPTOTIC EFFECTS IN CHONDROCYTES IS ASSOCIATED WITH SUPPRESSION OF THE MITOCHONDRIAL INFLAMMATION PATHWAY Open
One major aspects to consider while dealing with osteoarthritis is oxidative stress. This deleterious oxidative stress is responsible for the increased production of Reactive Oxygen Species and triggers several inflammatory pathways, inclu…
View article: Hepatoprotective and Anti-inflammatory Potential of Crude methanolic extract of Euphorbia pilulifera via NF-KB/Nrf2/Akt/TGF-β1 pathway
Hepatoprotective and Anti-inflammatory Potential of Crude methanolic extract of Euphorbia pilulifera via NF-KB/Nrf2/Akt/TGF-β1 pathway Open
Liver fibrosis is a natural process that initiates after liver injury to repair the damaged tissue. The liver has a significant capacity for self-repair of the damaged tissue. To a great extent, the miscellaneous interactions of immune cel…
View article: Cyclopeptide Kalata B12 as HCV-NS5A potent Inhibitor
Cyclopeptide Kalata B12 as HCV-NS5A potent Inhibitor Open
Hepatitis C Virus (HCV) is the leading cause of liver diseases globally, causing severe complications such as liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite the advent of successful regimens, still, 71 million indiv…
View article: Frequency and Risk Factors of Anemia Among Adult Female Population of District Swat Khyber Pakhtunkhwa Pakistan
Frequency and Risk Factors of Anemia Among Adult Female Population of District Swat Khyber Pakhtunkhwa Pakistan Open
Background: Globally, anemia is the most common problem and affecting approximately 15 to 30% of adult population and the most common nutritional deficiency worldwide. According to WHO, anemia is more prevalent in children and women and to…
View article: Assessment of Hygiene Status of Medical and Surgical Units Among Hospitals of Nowshera Swat & Peshawar Districts of Khyber Pakhtunkhwa Pakistan
Assessment of Hygiene Status of Medical and Surgical Units Among Hospitals of Nowshera Swat & Peshawar Districts of Khyber Pakhtunkhwa Pakistan Open
Objectives: Hygiene practices helps a lot in the prevention of infection among the admitted patients and an important component of infection prevention and patient safety. The aim of this study was to assess the hygiene status of medical a…
View article: The Insight of In Silico and In Vitro evaluation of Beta vulgaris phytochemicals against Alzheimer’s disease targeting acetylcholinesterase
The Insight of In Silico and In Vitro evaluation of Beta vulgaris phytochemicals against Alzheimer’s disease targeting acetylcholinesterase Open
B . vulgaris extracts possess antioxidant, anti-inflammatory along with its role in improving memory disorders. Subsequently, in vitro and in silico studies of its purified phytochemicals may expand complementary and alternative Alzheimer’…
View article: pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation
pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation Open
The rapid progression in biomaterial nanotechnology apprehends the potential of non-toxic and potent polysaccharide delivery modules to overcome oral chemotherapeutic challenges. The present study is aimed to design, fabricate and characte…
View article: Children’s Behavior toward Tooth Extraction: Comparison of Age, Chief Complaint, Method of Anesthesia, Dental Fear and Dental Anxiety with Level of Cooperation
Children’s Behavior toward Tooth Extraction: Comparison of Age, Chief Complaint, Method of Anesthesia, Dental Fear and Dental Anxiety with Level of Cooperation Open
Aim: To compare children’s behavior toward tooth extraction taking into account their gender, age, chief complaint, method of anesthesia, presence of dental fear and dental anxiety. Methodology: This cross sectional descriptive study was c…
View article: Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies
Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies Open
International audience
View article: Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation
Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation Open
The screening of hair follicles, dermal papilla cells, and keratinocytes through in vitro , in vivo , and histology has previously been reported to combat alopecia. Ficus benghalensis has been used conventionally to cure skin and hair diso…
View article: Perception of breast cancer risk factors: Dysregulation of TGF-β/miRNA axis in Pakistani females
Perception of breast cancer risk factors: Dysregulation of TGF-β/miRNA axis in Pakistani females Open
Breast cancer poses a serious health risk for women throughout the world. Among the Asian population, Pakistani women have the highest risk of developing breast cancer. One out of nine women is diagnosed with breast cancer in Pakistan. The…
View article: Tectona grandis leaf extract ameliorates hepatic fibrosis: Modulation of TGF- β /Smad signaling pathway and upregulating MMP3/TIMP1 ratio
Tectona grandis leaf extract ameliorates hepatic fibrosis: Modulation of TGF- β /Smad signaling pathway and upregulating MMP3/TIMP1 ratio Open
Tectona grandis L.f, leaves have potential to ameliorate liver fibrosis induced by CCl4 in mice via modulation of TGF-β1/Smad pathway and upregulated MMP3/TIMP1 ratio.
View article: Phytochemical analysis of Berberis lyceum methanolic extract and its antiviral activity through the restoration of MAPK signaling pathway modulated by HCV NS5A
Phytochemical analysis of Berberis lyceum methanolic extract and its antiviral activity through the restoration of MAPK signaling pathway modulated by HCV NS5A Open
Objective: To evaluate the antiviral activity and phytochemicals of selected plant extracts and their effect on the mitogen-activated protein kinase (MAPK) signaling pathway modulated by hepatitis C virus (HCV) nonstructural protein 5A (NS…
View article: Frequency of Breast feeding among working women of Multan.
Frequency of Breast feeding among working women of Multan. Open
Objectives: To determine the frequency of exclusive breast feeding among working women of Multan and to identify associations between socio demographic factors and exclusive breast feeding. Study Design: Descriptive cross sectional study. …
View article: Circulating tumor DNA in blood: Future genomic biomarkers for cancer detection
Circulating tumor DNA in blood: Future genomic biomarkers for cancer detection Open
Cancer is characterized by Darwinian evolution and is a primary cause of mortality and morbidity around the globe. Over the preceding decade, the treatment of cancer has been markedly improved by many targeted therapies, but these treatmen…
View article: Authentication of polyherbal formulations using PCR technique
Authentication of polyherbal formulations using PCR technique Open
Unprecedented growth in popularity of complementary medicines raised concerns about their quality and safety.So, there is need to develop methods for their sensitive, specific and accurate analysis.Authenticity and similarity of medicinal …
View article: Glycosylation of Recombinant Anticancer Therapeutics in Different Expression Systems with Emerging Technologies
Glycosylation of Recombinant Anticancer Therapeutics in Different Expression Systems with Emerging Technologies Open
Glycosylation, a posttranslational modification, has a major role in recombinant anticancer therapeutic proteins, as most of the approved recombinant therapeutics are glycoproteins. The constant amino acid sequence of therapeutics determin…