Buwei Yu
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View article: Capsaicin attenuates sepsis‑associated encephalopathy by inhibiting neuroinflammation and apoptosis whilst activating mitophagy through the BNIP3/NIX pathway
Capsaicin attenuates sepsis‑associated encephalopathy by inhibiting neuroinflammation and apoptosis whilst activating mitophagy through the BNIP3/NIX pathway Open
Sepsis‑induced abnormalities in brain function or sepsis‑associated encephalopathy (SAE) can manifest as cognitive dysfunction and other neuropsychiatric symptoms; however, the underlying mechanisms remain unclear. The aim of the present s…
View article: Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsis
Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsis Open
Objective: The pathogenesis of sepsis is still unknown. Sepsis 3.0 points out that "how to define sepsis and septic shock itself is still a challenge". This study confirmed the inevitability and universality of Hyperdynamic microcirculatio…
View article: Dexamethasone inhibits IL-8 via glycolysis and mitochondria-related pathway to regulate inflammatory pain
Dexamethasone inhibits IL-8 via glycolysis and mitochondria-related pathway to regulate inflammatory pain Open
Background Dexamethasone (Dexa) has been recently found to exert an analgesic effect, whose action is closely related to IL-8. However, whether dexamethasone induces antinociception via glycolysis and mitochondria-related pathways is still…
View article: Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsis
Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsis Open
Objective The pathogenesis of sepsis is still unknown. Sepsis 3.0 points out that “how to define sepsis and septic shock itself is still a challenge”. This study confirmed the inevitability and universality of Hyperdynamic microcirculation…
View article: The therapeutic potential of ultra-short-acting β-receptor antagonists in perioperative analgesic: Evidence from preclinical and clinical studies
The therapeutic potential of ultra-short-acting β-receptor antagonists in perioperative analgesic: Evidence from preclinical and clinical studies Open
Perioperative multimodal analgesia can reduce the side effects of a high concentration of opioids, improving the comfort of the patient. However, insufficient analgesia of this model has prompted researchers to explore new adjuvant analges…
View article: Short-Term Tasks and Long-Term Objectives of Chinese Anesthesiology Clinical Practice
Short-Term Tasks and Long-Term Objectives of Chinese Anesthesiology Clinical Practice Open
epidemic or pandemic.This is an opportunity for us to educate people, including the leadership of the national health authorities and medical institutions, about the critical roles of anesthesiologists in saving lives during a crisis like …
View article: Phosphorylation at Ser 727 Increases STAT3 Interaction with PKCε Regulating Neuron–Glia Crosstalk via IL-6-Mediated Hyperalgesia In Vivo and In Vitro
Phosphorylation at Ser 727 Increases STAT3 Interaction with PKCε Regulating Neuron–Glia Crosstalk via IL-6-Mediated Hyperalgesia In Vivo and In Vitro Open
Background and Aim. Interleukin-6 (IL-6) modulates neurons–glia crosstalk and subsequently triggers hyperalgesia. This study is aimed at investigating whether the interaction between protein kinase C epsilon (PKCε) and signal transducer an…
View article: αCaMKII in the lateral amygdala mediates PTSD-Like behaviors and NMDAR-Dependent LTD
αCaMKII in the lateral amygdala mediates PTSD-Like behaviors and NMDAR-Dependent LTD Open
View article: Segmental Zoster Paresis: A Literature Review
Segmental Zoster Paresis: A Literature Review Open
Background: Herpes zoster is an acute infectious skin disease that is induced by the re-activation of the virus incubated in nerve ganglions following initial infection with varicella-zoster virus in childhood. Herpes zoster mainly affects…
View article: Successful Treatment of Recalcitrant Psoriasis by Scopolamine and Propofol: A Report of Two Cases
Successful Treatment of Recalcitrant Psoriasis by Scopolamine and Propofol: A Report of Two Cases Open
View article: Acute Hypervolemic Infusion Can Improve Splanchnic Perfusion in Elderly Patients During Laparoscopic Colorectal Surgery
Acute Hypervolemic Infusion Can Improve Splanchnic Perfusion in Elderly Patients During Laparoscopic Colorectal Surgery Open
BACKGROUND There is no adequate evidence on how the long duration of laparoscopic surgery affects splanchnic perfusion in elderly patients or the efficacy of acute hypervolemic fluid infusion (AHFI) during the induction of anesthesia. Our …
View article: Estrogen receptors involvement in intervertebral discogenic pain of the elderly women: colocalization and correlation with the expression of Substance P in nucleus pulposus
Estrogen receptors involvement in intervertebral discogenic pain of the elderly women: colocalization and correlation with the expression of Substance P in nucleus pulposus Open
Estrogenic modulation of pain is an exceedingly complex phenomenon. However, whether estrogen is involved in discogenic low back pain still remains unclear. Here, immunoreactivity staining technique was used to examine the expression level…
View article: Abnormal Local Brain Activity Beyond the PainMatrix in Postherpetic Neuralgia Patients: AResting-State Functional MRI Study
Abnormal Local Brain Activity Beyond the PainMatrix in Postherpetic Neuralgia Patients: AResting-State Functional MRI Study Open
Background: Postherpetic neuralgia (PHN) patients suffer debilitating chronic pain, hyperalgesia, and allodynia, as well as emotional disorders such as insomnia, anxiety, and depression. The brain structure and functional basis of PHN are …
View article: The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model
The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model Open
Postoperative pain is a critical problem in clinical pain administration. Due to the unclear formation mechanism of postoperative pain, the treatment of postoperative pain is still in the symptomatic treatment stage and lacking satisfactor…
View article: Microstructural Abnormalities in Gray Matterof Patients with Postherpetic Neuralgia: ADiffusional Kurtosis Imaging Study
Microstructural Abnormalities in Gray Matterof Patients with Postherpetic Neuralgia: ADiffusional Kurtosis Imaging Study Open
Background: Changes in functional activity and connectivity have been shown in patients experiencing postherpetic neuralgia (PHN) pain. However, PHN-induced structural changes, particularly in the gray matter of which volume and density wa…
View article: BDNF release was significantly increased in the spinal cord dorsal horn following intraplantar injection of CFA, and intrathecal adminstration of roscovitine had no effects on BDNF release.
BDNF release was significantly increased in the spinal cord dorsal horn following intraplantar injection of CFA, and intrathecal adminstration of roscovitine had no effects on BDNF release. Open
BDNF release significantly increased between 0.5*P<0.05, **P<0.01. (n = 6, per group) (A). No significant difference was observed between the roscovitine and control groups 6 hours and 24 hours after CFA injection, P>0…
View article: U0126 attenuates spontaneous nociceptive responses, the elevation of p-Cdk5<sup>S159</sup> and Cdk5 activity in SCDH induced by formalin administration.
U0126 attenuates spontaneous nociceptive responses, the elevation of p-Cdk5<sup>S159</sup> and Cdk5 activity in SCDH induced by formalin administration. Open
a. U0126 treatment significantly decreases the numbers of spontaneous flinches induced by formalin injection in the 2nd phase (10–45 min), but not in the 1st phase (0–10 min). Data were analyzed by two-way ANOVA with …
View article: Regional anesthesia and lipid resuscitation for local anesthetic systemic toxicity in China: results of a survey by the orthopedic anesthesia group of the chinese society of anesthesiology
Regional anesthesia and lipid resuscitation for local anesthetic systemic toxicity in China: results of a survey by the orthopedic anesthesia group of the chinese society of anesthesiology Open
Chinese Clinical Trail Registry (Registration number # ChiCTR-EOR-15006960; Date of Retrospective Registration on August 23rd, 2015) http://www.chictr.org.cn/showproj.aspx?proj=11703 .