Beth Kelly
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View article: Missing data in single-cell transcriptomes reveals transcriptional shifts
Missing data in single-cell transcriptomes reveals transcriptional shifts Open
Profiling thousands of single cell transcriptomes is routine, yet cell prioritization based on response to biological perturbations is challenging and confounded by clustering, normalization and dimensionality reduction strategies. We deve…
View article: Prostaglandin E<sub>2</sub>controls the metabolic adaptation of T cells to the intestinal microenvironment
Prostaglandin E<sub>2</sub>controls the metabolic adaptation of T cells to the intestinal microenvironment Open
Immune cells must adapt to different environments during the course of an immune response. We studied the adaptation of CD8 + T cells to the intestinal microenvironment and how this process shapes their residency in the gut. CD8 + T cells …
View article: Research hotspots in dermatology journals
Research hotspots in dermatology journals Open
Bibliometric analysis of publication titles provides a panoramic view of global research trends. To understand the trends in dermatologic research, we obtained bibliometric data from 31 English-language dermatological journals that are MED…
View article: Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages
Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages Open
Metformin, a frontline treatment for type II diabetes mellitus, decreases production of the pro-form of the inflammatory cytokine IL-1β in response to LPS in macrophages. We found that it specifically inhibited pro-IL-1β production, having…