Charles A. Nelson
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View article: Caregiving Quality Across Development and Secure Base Knowledge among Adolescents with a History of Institutional Care
Caregiving Quality Across Development and Secure Base Knowledge among Adolescents with a History of Institutional Care Open
Secure base scripts are implicit schemas that guide perceptions, responses, and interactions by encapsulating expectations of support from attachment figures during distress. The current study investigated the impact of early institutional…
View article: General anesthesia in early infancy accelerates visual cortical development
General anesthesia in early infancy accelerates visual cortical development Open
How human brain function is established through protracted trajectories of development is not yet fully understood. Maturation of γ-aminobutyric acid (GABA) circuits drives critical periods of cortical development in animal models. Whether…
View article: Resting State Aperiodic and Periodic EEG Activity in Preschool-aged Autistic Children: Differences from Neurotypical Peers and Links to Language Skills
Resting State Aperiodic and Periodic EEG Activity in Preschool-aged Autistic Children: Differences from Neurotypical Peers and Links to Language Skills Open
Background: The neural mechanisms underpinning language development in autism spectrum disorder remain unclear. While prior studies have identified associations between resting-state EEG absolute power and language skills in autistic child…
View article: Altered oscillatory coupling reflects possible inhibitory interneuron dysfunction in Rett syndrome
Altered oscillatory coupling reflects possible inhibitory interneuron dysfunction in Rett syndrome Open
Rett syndrome is a rare neurodevelopmental disorder caused primarily by pathogenic variants in the MECP2 gene, leading to lifelong cognitive impairments. To understand the broad neural disruptions in Rett syndrome, it is essential to exami…
View article: Feasibility and acceptability of magnetic resonance imaging and electroencephalography for child neurodevelopmental research in rural Ethiopia
Feasibility and acceptability of magnetic resonance imaging and electroencephalography for child neurodevelopmental research in rural Ethiopia Open
Background Magnetic resonance imaging (MRI) and electroencephalography (EEG) are valuable tools for studying neuroanatomical and electrophysiological features of early brain development. Studies implementing neuroimaging tools in low- and …
View article: Adaptive functioning at age 18 years following severe early deprivation: Results of a randomized controlled trial.
Adaptive functioning at age 18 years following severe early deprivation: Results of a randomized controlled trial. Open
In the present study, we examined adaptive functioning data from the Bucharest Early Intervention Project, a randomized controlled trial of foster care as an alternative to institutional care following exposure to severe psychosocial depri…
View article: The epigenetic impacts of pubertal acceleration following early caregiver disruptions
The epigenetic impacts of pubertal acceleration following early caregiver disruptions Open
A stable caregiving environment early in life is essential for children’s development, and disruptions have the potential to impact biological processes. Using data from the Bucharest Early Intervention Project, we examined a developmental…
View article: Interaction of fatty acid composition and temperature cycling on melting properties of milk fat
Interaction of fatty acid composition and temperature cycling on melting properties of milk fat Open
Fat was extracted from milk produced by 40 individual cows that were specifically selected over time in lactation to produce a graduation of natural samples with a wider range of milk fatty acid composition (i.e., ratio of de novo to prefo…
View article: Implementation of mobile EEG for resting-state and visual evoked potentials in young children in rural Ethiopia
Implementation of mobile EEG for resting-state and visual evoked potentials in young children in rural Ethiopia Open
Children living in low- and middle-income countries (LMIC) are at disproportionately higher risk of neurodevelopmental delays due to exposure to adverse biological and environmental hazards. In infancy, global developmental assessments, su…
View article: Income Insufficiency Impacts Early Brain Development In Infants Facing Increased Psychosocial Adversity: A Network-based Approach
Income Insufficiency Impacts Early Brain Development In Infants Facing Increased Psychosocial Adversity: A Network-based Approach Open
Early adversity is associated with brain changes that negatively impact development, social-emotional functioning, and academic achievement. The multifaceted nature of adversity complicates efforts to isolate specific factors that affect b…
View article: Longitudinal Trajectories of Aperiodic <scp>EEG</scp> Activity in Early to Middle Childhood
Longitudinal Trajectories of Aperiodic <span>EEG</span> Activity in Early to Middle Childhood Open
Aperiodic electroencephalography (EEG) activity is hypothesized to index biological mechanisms that underpin brain functioning. This longitudinal study characterized the developmental trajectories of the aperiodic slope (i.e., aperiodic ex…
View article: Honey Bees Can Use Sequence Learning to Predict Rewards from a Prior Unrewarded Visual Stimulus
Honey Bees Can Use Sequence Learning to Predict Rewards from a Prior Unrewarded Visual Stimulus Open
Learning to anticipate upcoming events can increase fitness by allowing animals to choose the best course of action, and many species can learn sequences of events and anticipate rewards. To date, most studies have focused on sequences ove…
View article: Growth charts of infant visual neurodevelopment generalize across global contexts
Growth charts of infant visual neurodevelopment generalize across global contexts Open
Normative brain growth charts in early life hold great promise for furthering basic and clinical science. We leverage the rapid, substantial development of visual cortex function that is indexed by visual-evoked potentials (VEP) in electro…
View article: Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures
Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures Open
Background Tuberous Sclerosis Complex (TSC) is a rare genetic condition caused by mutation to TSC1 or TSC2 genes, with a population prevalence of 1/7000 births. TSC manifests behaviorally with features of autism, epilepsy, and intellectual…
View article: Physical and neurophysiological maturation associated with <scp>ADHD</scp> among previously institutionalized children: a randomized controlled trial
Physical and neurophysiological maturation associated with <span>ADHD</span> among previously institutionalized children: a randomized controlled trial Open
Background Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental outcome among children with a history of early institutional care. Prior research on institutionalized children suggested that accelerated physical g…
View article: Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition
Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition Open
Malnutrition affects over 30 million children annually and has profound immediate and enduring repercussions. Survivors often suffer lasting neurocognitive consequences that impact academic performance and socioeconomic outcomes. Mechanist…
View article: Unraveling the relationship between stress exposure and childhood anxiety: Considering accumulation, impact, and type in the first five years of life
Unraveling the relationship between stress exposure and childhood anxiety: Considering accumulation, impact, and type in the first five years of life Open
Exposure to stressful events is linked to anxiety symptoms in children, although research examining this association in the first five years of life is limited. We sought to examine the role of various aspects of family stressful experienc…
View article: Changes in early aperiodic EEG activity are linked to autism diagnosis and language development in infants with family history of autism
Changes in early aperiodic EEG activity are linked to autism diagnosis and language development in infants with family history of autism Open
Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of language delays, the neurobiology underlying such language challenges remains unclear. Prior research has shown reduced EEG power across…
View article: Impact of maternal antenatal nutrition and infection treatment interventions on Longitudinal Infant Development and Growth in rural Ethiopia: protocol of the LIDG child follow-up study
Impact of maternal antenatal nutrition and infection treatment interventions on Longitudinal Infant Development and Growth in rural Ethiopia: protocol of the LIDG child follow-up study Open
Introduction Maternal undernutrition and inflammation in utero may significantly impact the neurodevelopmental potential of offspring. However, few studies have investigated the effects of pregnancy interventions on long-term child growth …