Carolina Allers
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View article: Immunometabolic reprogramming by caloric restriction leads to protection from SIV in rhesus macaques 3052
Immunometabolic reprogramming by caloric restriction leads to protection from SIV in rhesus macaques 3052 Open
Description Nutrient metabolism influences HIV-1 replication, immunity, and chronic inflammation, yet it is challenging to target therapeutically. We hypothesized that modulating metabolism via caloric restriction (CR), a safe, anti-aging …
View article: Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques
Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques Open
Modern antiretroviral therapy (ART) regimens have revolutionized the management of human immunodeficiency virus (HIV) and transformed it from a life-threatening disease to a manageable chronic condition. Despite the durable viral suppressi…
View article: RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir genesis in the Gut Mucosa
RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir genesis in the Gut Mucosa Open
Cytomegalovirus (CMV) is a prevalent β-herpesvirus that persists asymptomatically in immunocompetent hosts. In people with HIV-1 (PWH), CMV is associated with persistence of the HIV-1 reservoir and particular inflammatory related co-morbid…
View article: Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study of Plasmodium fragile Co-Infection of ART-Treated SIVmac239+ Rhesus Macaques
Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study of Plasmodium fragile Co-Infection of ART-Treated SIVmac239+ Rhesus Macaques Open
Human immunodeficiency virus (HIV) and malaria, caused by infection with Plasmodium spp., are endemic in similar geographical locations. As a result, there is high potential for HIV/Plasmodium co-infection, which increases the pathology of…
View article: Co-Infection of ART-treated SIVmac239+ Rhesus Macaques with Plasmodium fragile Results in Elevated Inflammation which Associates with Neutrophil Function
Co-Infection of ART-treated SIVmac239+ Rhesus Macaques with Plasmodium fragile Results in Elevated Inflammation which Associates with Neutrophil Function Open
Human immunodeficiency virus (HIV) and malaria, caused by infection with Plasmodium spp., are endemic in similar geographical locations. As a result, there is high potential for HIV/Plasmodium co-infection, which increases the pathology of…
View article: A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates
A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates Open
View article: Comparison of fine‐needle aspiration techniques
Comparison of fine‐needle aspiration techniques Open
Background Fine‐needle aspiration (FNA) has been reported since 1912 beginning with the use of trocars and other specialized instruments that were impractical. Since then, FNA has proven to be a successful alternative technique to excision…
View article: Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration
Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration Open
View article: Long-primed germinal centres with enduring affinity maturation and clonal migration
Long-primed germinal centres with enduring affinity maturation and clonal migration Open
View article: <scp>Multi‐site</scp> proficiency testing for validation and standardization of assays to detect specific pathogen‐free viruses, coronaviruses, and other agents in nonhuman primates
<span>Multi‐site</span> proficiency testing for validation and standardization of assays to detect specific pathogen‐free viruses, coronaviruses, and other agents in nonhuman primates Open
In efforts to increase rigor and reproducibility, the USA National Primate Research Centers (NPRCs) have focused on qualification of reagents, cross‐laboratory validations, and proficiency testing for methods to detect infectious agents an…
View article: Table of Contents
Table of Contents Open
View article: Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques
Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques Open
View article: “Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques”
“Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques” Open
SARS-CoV-2 induces a wide range of disease severity ranging from asymptomatic infection, to a life-threating illness, particularly in the elderly and persons with comorbid conditions. Among those persons with serious COVID-19 disease, acut…
View article: Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages
Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages Open
While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed…
View article: Author response: Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages
Author response: Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract While tuberculosis (TB) is a risk factor i…
View article: Allogeneic Mesenchymal Stem Cells Infusion to an ALS Patient Proved to be Safe and Capable to Initiate Clinical Recuperation: Review
Allogeneic Mesenchymal Stem Cells Infusion to an ALS Patient Proved to be Safe and Capable to Initiate Clinical Recuperation: Review Open
No cure has been found for Amyotrophic Lateral Sclerosis (ALS) despite several studies using drugs or related compounds. Background: Cellular, molecular and preclinical studies have suggested that the use of Mesenchymal Stem Cells (MSC) ma…
View article: Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages
Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages Open
While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis worsens HIV-1 pathogenesis remain poorly understood. Recently, we showed that HIV-1 infection and spread are exacerb…
View article: Characterization of heart macrophages in rhesus macaques as a model to study cardiovascular disease in humans
Characterization of heart macrophages in rhesus macaques as a model to study cardiovascular disease in humans Open
Rhesus macaques are physiologically similar to humans and, thus, have served as useful animal models of human diseases including cardiovascular disease. The purpose of this study was to characterize the distribution, composition, and pheno…
View article: Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis
Lack of susceptibility in neonatally infected rhesus macaques to simian immunodeficiency virus-induced encephalitis Open
View article: Overexpression and activation of colony‐stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroHIV
Overexpression and activation of colony‐stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroHIV Open
In the present study, we investigated whether colony‐stimulating factor 1 receptor (CSF1R) is expressed on brain macrophages and microglia in the human and macaque brain and whether it is upregulated and activated after lentivirus infectio…
View article: Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques
Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques Open
The intestinal tract is a primary barrier to invading pathogens and contains immune cells, including lymphocytes and macrophages. We previously reported that CD163+CD206− (single-positive [SP]) interstitial macrophages of the lung are shor…
View article: Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages Open
The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we sh…
View article: Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging
Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging Open
Neutrophils, basophils, and monocytes are continuously produced in bone marrow via myelopoiesis, circulate in blood, and are eventually removed from circulation to maintain homeostasis. To quantitate the kinetics of myeloid cell movement d…
View article: Overexpression and activation of colony-stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroAIDS
Overexpression and activation of colony-stimulating factor 1 receptor in the SIV/macaque model of HIV infection and neuroAIDS Open
View article: Tuberculosis Boosts HIV-1 Production by Macrophages Through IL-10/STAT3-Dependent Tunneling Nanotube Formation
Tuberculosis Boosts HIV-1 Production by Macrophages Through IL-10/STAT3-Dependent Tunneling Nanotube Formation Open
View article: Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome
Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome Open
Monocytes/macrophages are a diverse group of cells that act as first responders in innate immunity and then as mediators for adaptive immunity to help clear infections. In performing these functions, however, the macrophage inflammatory re…