Derek C. Angus
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View article: Medicaid's role in critical care after Medicaid expansion: evidence from Virginia
Medicaid's role in critical care after Medicaid expansion: evidence from Virginia Open
Introduction Medicaid provides access to care for low-income patients facing life-threatening illnesses who are cared for in intensive care units (ICUs). Despite the growth of Medicaid coverage with the Affordable Care Act, little is known…
View article: Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality
Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality Open
Importance Sepsis survivors experience high morbidity and mortality after discharge, but health systems lack effective approaches to improve recovery. Objective To evaluate the effect of a sepsis transition and recovery (STAR) program comp…
View article: Design and methods of an adaptive trial to test comparative effectiveness of readmission reduction approaches following infection and sepsis hospitalizations (ACCOMPLISH)
Design and methods of an adaptive trial to test comparative effectiveness of readmission reduction approaches following infection and sepsis hospitalizations (ACCOMPLISH) Open
This trial is registered at clinicaltrials.gov (NCT04829188). https://clinicaltrials.gov/study/NCT04829188. Date of registration: January 4, 2021.
View article: An Educational Video Game in Trauma Triage at Nontrauma Centers
An Educational Video Game in Trauma Triage at Nontrauma Centers Open
Importance Understanding how behavioral interventions work and whom they help can increase their effectiveness. Objective To evaluate the mechanism of action and heterogeneity of the estimated treatment effect of a customized video game ( …
View article: Optimal Vasopressin Initiation in Septic Shock
Optimal Vasopressin Initiation in Septic Shock Open
Importance Norepinephrine is the first-line vasopressor for patients with septic shock. When and whether a second agent, such as vasopressin, should be added is unknown. Objective To derive and validate a reinforcement learning model to de…
View article: Microsampling in toxicology studies – maximising the scientific, business and 3Rs advantages
Microsampling in toxicology studies – maximising the scientific, business and 3Rs advantages Open
Adoption of a blood microsampling technique can reduce or avoid the use of satellite animals (rodents) for toxicokinetics or other purposes in discovery and toxicology studies and provides refinements applicable for both rodents and larger…
View article: Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement
Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement Open
The current lack of specific therapy for prevention or treatment of AKI demands refinement of future clinical trial design. Here we report the consensus findings of the 31st ADQI group meeting which has attempted to address these issues in…
View article: Your Mileage May Vary
Your Mileage May Vary Open
Kevin G. Buell, MBBS; Alexandra B. Spicer, MS; Jonathan D. Casey, MD, MSc; Kevin P. Seitz, MD, MSc; Edward T. Qian, MD, MSc; Emma J. Graham Linck, MS; Wesley H. Self, MD, MPH; Todd W. Rice, MD, MSc; Pratik Sinha, MBChB, PhD; Paul J. Young,…
View article: Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL) Open
After the publication of the article, we have been informed that the name of a contributor in the list of REVIVAL investigators was given incomplete. He was given as “Patrick Honore” or “Honore P” but he should have been cited as “Patrick …
View article: Using a theory-based, customized video game as an educational tool to improve physicians’ trauma triage decisions: study protocol for a randomized cluster trial
Using a theory-based, customized video game as an educational tool to improve physicians’ trauma triage decisions: study protocol for a randomized cluster trial Open
Background Transfer of severely injured patients to trauma centers, either directly from the field or after evaluation at non-trauma centers, reduces preventable morbidity and mortality. Failure to transfer these patients appropriately (i.…
View article: Three Decades of Sepsis in the United Kingdom: Tracing the Tides of Time
Three Decades of Sepsis in the United Kingdom: Tracing the Tides of Time Open
"Three Decades of Sepsis in the UK: Tracing the Tides of Time." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL) Open
Among critically ill patients with SA-AKI, ilofotase alfa did not improve day 28 survival. There may, however, be reduced MAKE90 events. No safety concerns were identified.
View article: Prospective Assessment of Humoral and Cellular Immune Responses to a Third COVID-19 mRNA Vaccine Dose Among Immunocompromised Individuals
Prospective Assessment of Humoral and Cellular Immune Responses to a Third COVID-19 mRNA Vaccine Dose Among Immunocompromised Individuals Open
Background Improved coronavirus disease 2019 (COVID-19) prevention is needed for immunocompromised individuals. Methods A prospective study was performed of health care workers (HCW) and immunocompromised participants with baseline serolog…
View article: A Prospective Cohort Protocol for the Remnant Investigation in Sepsis Study
A Prospective Cohort Protocol for the Remnant Investigation in Sepsis Study Open
BACKGROUND: Sepsis is a common and deadly syndrome, accounting for more than 11 million deaths annually. To mature a deeper understanding of the host and pathogen mechanisms contributing to poor outcomes in sepsis, and thereby possibly inf…
View article: Simvastatin in Critically Ill Patients with Covid-19
Simvastatin in Critically Ill Patients with Covid-19 Open
BACKGROUND: The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS: In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated sim…
View article: Automatic Population of the Case Report Forms for an International Multifactorial Adaptive Platform Trial Amid the COVID-19 Pandemic
Automatic Population of the Case Report Forms for an International Multifactorial Adaptive Platform Trial Amid the COVID-19 Pandemic Open
Objectives To automatically populate the case report forms (CRFs) for an international, pragmatic, multifactorial, response-adaptive, Bayesian COVID-19 platform trial. Methods The locations of focus included 27 hospitals and 2 large electr…