César A. Arias
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View article: Loss of the Ferripyochelin Receptor FptA Drives Reduced Cefiderocol Susceptibility and Impairs Fitness in <i>Pseudomonas aeruginosa</i> PA14
Loss of the Ferripyochelin Receptor FptA Drives Reduced Cefiderocol Susceptibility and Impairs Fitness in <i>Pseudomonas aeruginosa</i> PA14 Open
Pseudomonas aeruginosa is an opportunistic human pathogen and a frequent cause of multidrug-resistant infections. This organism continues to evade antimicrobial therapy despite the clinical introduction of new anti-pseudomonal antibiotics …
View article: Therapeutic approach to difficult-to-treat multidrug-resistant enterococcal infections
Therapeutic approach to difficult-to-treat multidrug-resistant enterococcal infections Open
Difficult-to-treat (DTR) enterococcal infections, particularly those caused by multidrug-resistant Enterococcus faecium and Enterococcus faecalis , pose significant clinical challenges due to limited treatment options and high rates of tre…
View article: Cefepime-zidebactam therapy for extensively drug-resistant <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i> infection as a bridge to liver transplantation
Cefepime-zidebactam therapy for extensively drug-resistant <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i> infection as a bridge to liver transplantation Open
Background Infections due to antimicrobial-resistant Gram-negative organisms present increasingly difficult therapeutic challenges, especially in the presence of metallo-β-lactamases. We present the case of a patient with cholangitis due t…
View article: LiaS-dependent activation of the MadR regulon enables cross-talk between<i>Enterococcus faecalis</i>cell envelope defense systems
LiaS-dependent activation of the MadR regulon enables cross-talk between<i>Enterococcus faecalis</i>cell envelope defense systems Open
Enterococci are gastrointestinal commensals that must defend their cell envelope against antimicrobial peptides derived from the host and other members of the microbiota. The signaling systems LiaFSR and MadRS are pivotal for survival in t…
View article: Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity
Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity Open
Small alterations during the early stages of the innate immune response to an implant can drive large changes in adaptive immunity. Biomaterials for regenerative purposes can be engineered to modulate this immune response in beneficial way…
View article: Clinical and Genomic Characterization of Recalcitrant Enterococcal Bacteremia: A Multicenter Prospective Cohort Study (VENOUS)
Clinical and Genomic Characterization of Recalcitrant Enterococcal Bacteremia: A Multicenter Prospective Cohort Study (VENOUS) Open
Background Patients with recalcitrant enterococcal bloodstream infections are at greater risk of adverse outcomes. We identified patients in the 2016-2022 Vancomycin-Resistant Enterococcal Bacteremia Outcomes Study (VENOUS) cohort experien…
View article: Geographic divergence of methicillin-resistant <i>Staphylococcus aureus</i> ST5-SCC <i>mec</i> I in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes
Geographic divergence of methicillin-resistant <i>Staphylococcus aureus</i> ST5-SCC <i>mec</i> I in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health menace. The global spread of MRSA is characterized by successive waves of epidemic clones dominating specific geographical regions. The acquisition of genes encodi…
View article: Carbapenem-Resistant, Virulence Plasmid–Harboring <i>Klebsiella pneumoniae,</i> United States
Carbapenem-Resistant, Virulence Plasmid–Harboring <i>Klebsiella pneumoniae,</i> United States Open
Carbapenem-resistant and virulence plasmid-harboring Klebsiella pneumoniae (pVir-CRKP) has emerged and spread globally, yet clinical investigations from the United States remain limited. We conducted a genomic analysis of 884 unique carbap…
View article: Evaluating the Benefits and Limits of Multiple Displacement Amplification With Whole‐Genome Oxford Nanopore Sequencing
Evaluating the Benefits and Limits of Multiple Displacement Amplification With Whole‐Genome Oxford Nanopore Sequencing Open
Multiple displacement amplification (MDA) outperforms conventional PCR in long fragment and whole‐genome amplification, making it attractive to couple MDA with long‐read sequencing of samples with limited quantities of DNA to obtain improv…
View article: A call for the United States to continue investing in science
A call for the United States to continue investing in science Open
International audience
View article: Genomic Insights into Colistin and Tigecycline Resistance in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Harboring blaKPC Genes in Ecuador
Genomic Insights into Colistin and Tigecycline Resistance in ESBL-Producing Escherichia coli and Klebsiella pneumoniae Harboring blaKPC Genes in Ecuador Open
Introduction: Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are resistant to third-generation cephalosporins (3GCs), carbapenems, colistin, and tigecycline, making them a major public health priority, mainly within t…