Christy L. Avery
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View article: Blood pressure is associated with ultra-processed food intake in a sex- and age-specific manner during the transition to adulthood in Cebu, Philippines
Blood pressure is associated with ultra-processed food intake in a sex- and age-specific manner during the transition to adulthood in Cebu, Philippines Open
Progression towards elevated blood pressure (BP) may begin as early as adolescence. In low- and middle-income countries (LMICs), consumption of ultra-processed foods (UPFs), which are linked to poor cardiometabolic health, is often highest…
View article: Plasma Proteomics of Cognitive Resilience to ADRD: The ARIC Study
Plasma Proteomics of Cognitive Resilience to ADRD: The ARIC Study Open
Background Older adults may exhibit different levels of cognitive function despite expressing the Alzheimer's disease and related disorders (ADRD) biomarker levels. This observation, attributed to cognitive resilience, operates through unc…
View article: Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults
Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults Open
Asthma is a heterogeneous condition that is often comorbid with obesity and influenced by diverse risk factors. Elucidating the association of gut microbial characteristics with asthma could improve our understanding of the pathophysiology…
View article: Sex Modifies Metabolic Pathways Associated with Lipids in Untargeted Metabolomics: The Coronary Artery Risk Development in Young Adults (CARDIA) Study, 2005–2006
Sex Modifies Metabolic Pathways Associated with Lipids in Untargeted Metabolomics: The Coronary Artery Risk Development in Young Adults (CARDIA) Study, 2005–2006 Open
Background: There are differences in lipid metabolism by sex that are relevant for health, but metabolic pathways are not fully understood. We investigated sex differences in cross-sectional associations between metabolic pathways identifi…
View article: Association between neutrophil to lymphocyte ratio and Alzheimer's disease in large biobank cohorts
Association between neutrophil to lymphocyte ratio and Alzheimer's disease in large biobank cohorts Open
Background Neutrophil to lymphocyte ratio (NLR) is an inflammatory biomarker for chronic disease that also may provide evidence for peripheral innate immune activation in Alzheimer's disease (AD) pathogenesis. Objective The objective of th…
View article: Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology
Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology Open
BACKGROUND AND OBJECTIVES: Prospective measures of plasma and cerebral MRI biomarkers of Alzheimer disease (AD) and vascular neuropathology provide an opportunity to investigate possible mechanisms linking liver disease and dementia. We ai…
View article: Body Mass Index Modifies Associations Between Diet Quality and Circulating Metabolites: The CARDIA Study, 2005 to 2006
Body Mass Index Modifies Associations Between Diet Quality and Circulating Metabolites: The CARDIA Study, 2005 to 2006 Open
Background Obesity perturbs metabolism, resulting in differential diet–disease associations, but metabolic pathways that differ by obesity remain unclear. We investigated whether cross‐sectional associations between metabolites and diet qu…
View article: Short-term Repeatability of Artificial Intelligence Estimated Electrocardiographic Age
Short-term Repeatability of Artificial Intelligence Estimated Electrocardiographic Age Open
Advancements in artificial intelligence have enabled estimation of cardiac age from raw ECG waveforms. ECG-age is a novel metric that provides insights into cardiac function and has shown potential for CVD risk prediction. However, its sho…
View article: Large-scale genome-wide analyses of stuttering
Large-scale genome-wide analyses of stuttering Open
Developmental stuttering is a highly heritable, common speech condition characterized by prolongations, blocks and repetitions of speech. Although stuttering is highly heritable and enriched within families, the genetic architecture is lar…
View article: Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations Open
Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely unders…
View article: Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk
Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk Open
The abundance of Lp(a) protein holds significant implications for the risk of cardiovascular disease (CVD), which is directly impacted by the copy number (CN) of KIV-2, a 5.5 kbp sub-region. KIV-2 is highly polymorphic in the population an…
View article: Advancing Cardiovascular Risk Assessment with Artificial Intelligence: Opportunities and Implications in North Carolina.
Advancing Cardiovascular Risk Assessment with Artificial Intelligence: Opportunities and Implications in North Carolina. Open
Cardiovascular disease mortality is increasing in North Carolina with persistent inequality by race, income, and location. Artificial intelligence (AI) can repurpose the widely available electrocardiogram (ECG) for enhanced assessment of c…
View article: Genome-wide association study reveals shared and distinct genetic architecture underlying fatty acid and bioactive oxylipin metabolites in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Genome-wide association study reveals shared and distinct genetic architecture underlying fatty acid and bioactive oxylipin metabolites in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Open
Bioactive fatty acid-derived oxylipin molecules play key roles in mediating inflammation and oxidative stress, which underlie many chronic diseases. Circulating levels of fatty acids and oxylipins are influenced by both environmental and g…
View article: Variation in Population Attributable Fraction of Dementia Associated with Potentially Modifiable Risk Factors by Race and Ethnicity in the US
Variation in Population Attributable Fraction of Dementia Associated with Potentially Modifiable Risk Factors by Race and Ethnicity in the US Open
Importance: Identifying modifiable risk factors that are associated with dementia burden across racial and ethnic groups in the population can yield insights into the potential effectiveness of interventions in preventing dementia and redu…
View article: Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations Open
Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely unders…
View article: Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology
Nonalcoholic Fatty Liver Disease and Longitudinal Change in Imaging and Plasma Biomarkers of Alzheimer Disease and Vascular Pathology Open
Midlife NAFLD shows associations with AD and accumulating vascular pathology, revealing potential pathways linking liver function to dementia. Plasma biomarkers of neuropathology and neuronal injury may serve as easily measurable and dynam…