Jürgen C. Becker
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View article: High-resolution spatial transcriptomics uncover epidermal-dermal divergences in Merkel cell carcinoma: spatial context reshapes the gene expression landscape
High-resolution spatial transcriptomics uncover epidermal-dermal divergences in Merkel cell carcinoma: spatial context reshapes the gene expression landscape Open
View article: Data from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Data from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Evolution and outgrowth of drug-resistant cancer cells are common causes of treatment failure. Patients with leukemic cutaneous T-cell lymphoma have a poor prognosis because of the development of drug resistance and severe bacterial infect…
View article: Table S2 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Table S2 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Antibodies used (with vendor, catalogue number and RRID)
View article: Table S1 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Table S1 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Patient information
View article: Supplementary Figures S1-S17 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Supplementary Figures S1-S17 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
S1 shows sample and analysis pipeline overview. S2 shows malignant-associated gene and surface marker expression in PT17. S3 shows single-cell subclone identification by scTCR-seq, transcriptome and copy-number aberration inference. S4 sho…
View article: Tertiary lymphoid structures in Merkel cell carcinoma facilitate naïve and central memory T-cell infiltration linked to immunotherapy response
Tertiary lymphoid structures in Merkel cell carcinoma facilitate naïve and central memory T-cell infiltration linked to immunotherapy response Open
Background The presence of tertiary lymphoid structures (TLS) in solid tumors, including Merkel cell carcinoma (MCC), is associated with a better prognosis and a better response to immunotherapy with immune checkpoint inhibition (ICI). The…
View article: Leukemia cutis with concomitant acrodermatitis chronica atrophicans and chronic B‐cell lymphocytic leukemia: complete clearance under doxycycline therapy
Leukemia cutis with concomitant acrodermatitis chronica atrophicans and chronic B‐cell lymphocytic leukemia: complete clearance under doxycycline therapy Open
View article: Outcome of systemic therapy in patients with advanced rare skin cancers: A retrospective multicenter DeCOG study of 209 patients
Outcome of systemic therapy in patients with advanced rare skin cancers: A retrospective multicenter DeCOG study of 209 patients Open
Type and outcome of systemic therapy differed between cancer entities. Efficacy of ICI was high in PDS and AS, moderate in KS, and low in CAC. Patients with advanced CAC revealed an extremely poor prognosis regardless of the type of therap…
View article: IFN γ and the IFN γ Signaling Pathways in Merkel Cell Carcinoma
IFN γ and the IFN γ Signaling Pathways in Merkel Cell Carcinoma Open
Recent preclinical and clinical studies have confirmed the essential role of interferons in the host’s immune response against malignant cells. Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer strongly associated with Merkel c…
View article: Deutsch‐Österreichische S2k‐Leitlinie: Anale Dysplasien und Analkarzinom‐Screening bei Menschen mit HIV
Deutsch‐Österreichische S2k‐Leitlinie: Anale Dysplasien und Analkarzinom‐Screening bei Menschen mit HIV Open
Zusammenfassung Menschen mit HIV sind im Vergleich zur Allgemeinbevölkerung bis zu 100‐mal häufiger von Analkarzinomen betroffen. Werden Vorläufer, das bedeutet hochgradige anale Dysplasien, diagnostiziert und therapiert, kann das Risiko f…
View article: Sex-specific survival in advanced metastatic melanoma – a DeCOG study on 2032 patients of the multicenter prospective skin cancer registry ADOREG
Sex-specific survival in advanced metastatic melanoma – a DeCOG study on 2032 patients of the multicenter prospective skin cancer registry ADOREG Open
No overall sex-specific survival differences were detected for metastatic melanoma patients in the first-line therapy setting. According to subgroup analyses males show a trend towards a survival advantage over females.
View article: Inhibitory Immune Checkpoints beyond Programmed Cell Death Ligand 1 in Merkel Cell Carcinoma: Abundant Expression of TIGIT Independent of the Presence of Merkel Cell Polyoma Virus
Inhibitory Immune Checkpoints beyond Programmed Cell Death Ligand 1 in Merkel Cell Carcinoma: Abundant Expression of TIGIT Independent of the Presence of Merkel Cell Polyoma Virus Open
Merkel cell carcinoma is a rare, aggressive skin cancer in which Merkel cell polyoma virus (MCPyV) is frequently pathogenically involved. After failure of anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, t…
View article: Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Evolution and outgrowth of drug-resistant cancer cells are common causes of treatment failure. Patients with leukemic cutaneous T-cell lymphoma have a poor prognosis because of the development of drug resistance and severe bacterial infect…
View article: Impaired Overall Survival of Melanoma Patients Due to Antibiotic Use Prior to Immune Checkpoint Inhibitor Therapy: Systematic Review and Meta-Analysis
Impaired Overall Survival of Melanoma Patients Due to Antibiotic Use Prior to Immune Checkpoint Inhibitor Therapy: Systematic Review and Meta-Analysis Open
Background: The gut microbiome plays a pivotal role in shaping systemic immunity and modulating anti-tumor responses. Preclinical and clinical studies have shown that higher gut microbial diversity and the presence of specific commensal ta…
View article: German‐Austrian guideline on screening for anal dysplasia and anal carcinoma in people living with HIV
German‐Austrian guideline on screening for anal dysplasia and anal carcinoma in people living with HIV Open
Summary People with HIV are up to 100 times more likely to develop anal carcinoma compared to the general population. Diagnosing and treating precursor lesions, specifically high‐grade anal dysplasia, can significantly reduce the risk of d…
View article: Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma
Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma Open
The KIT/c-KIT proto-oncogene is frequently over-expressed in Merkel cell carcinoma (MCC), an aggressive skin cancer commonly caused by Merkel cell polyomavirus (MCPyV). Here, we demonstrated that truncated MCPyV-encoded large T-antigen (LT…
View article: Redirecting resistance evolution in <i>BRAF<sup>V600</sup> </i> melanoma by inhibition of the peroxiredoxin-thioredoxin system
Redirecting resistance evolution in <i>BRAF<sup>V600</sup> </i> melanoma by inhibition of the peroxiredoxin-thioredoxin system Open
Summary Drug-tolerant persister cells (DTPs) exhibit remarkable cell state heterogeneity and phenotypic evolvability. However, the central question of how DTPs epigenetically coordinate their metabolic flexibility to adapt early to therape…
View article: The significance of <scp>PAX5</scp> in Merkel cell carcinoma
The significance of <span>PAX5</span> in Merkel cell carcinoma Open
Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial‐, neuroendocrine‐, and lymphoid‐associated genes. Here, we focused on B‐cell differentiation, which is characterised by the coexpression of PAX5 and Td…
View article: Immuncheckpoint‐Inhibitoren bei Kindern mit Xeroderma pigmentosum und fortgeschrittenem kutanen Plattenepithelkarzinom: Fallvorstellung und kurzer Überblick
Immuncheckpoint‐Inhibitoren bei Kindern mit Xeroderma pigmentosum und fortgeschrittenem kutanen Plattenepithelkarzinom: Fallvorstellung und kurzer Überblick Open
Zusammenfassung Patienten mit Xeroderma pigmentosum (XP) entwickeln häufig bereits in jungen Jahren Hautkrebs, darunter auch kutane Plattenepithelkarzinome (cSCC). Das mediane Sterbealter liegt bei 32 Jahren, und 60% der XP‐Patienten verst…
View article: Preclinical <i>in vitro</i> and <i>in vivo</i> evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas
Preclinical <i>in vitro</i> and <i>in vivo</i> evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas Open
Background Prognosis and quality of life in patients with advanced cutaneous T-cell lymphoma (CTCL), particularly in those with Sézary syndrome (SS) or advanced-stage mycosis fungoides (MF), are poor. Monoclonal antibodies or antibody–drug…
View article: Low Intratumoral CD200 Protein Expression in Primary Merkel Cell Carcinoma Is a Strong Predictor for Disease Relapse
Low Intratumoral CD200 Protein Expression in Primary Merkel Cell Carcinoma Is a Strong Predictor for Disease Relapse Open
Background: Merkel cell carcinoma (MCC) is a rare and frequently fatal form of skin cancer. Apart from Programmed Cell Death Protein 1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling, there is a lack of knowledge regarding other immune …
View article: Immune checkpoint inhibitors for children with xeroderma pigmentosum and advanced cutaneous squamous cell carcinoma: A case presentation and brief review
Immune checkpoint inhibitors for children with xeroderma pigmentosum and advanced cutaneous squamous cell carcinoma: A case presentation and brief review Open
Summary Patients with xeroderma pigmentosum (XP) frequently develop skin cancers early in life, including cutaneous squamous cell carcinoma (cSCC). The median age of death is 32 years and 60% of XP patients die before the age of 20 years. …
View article: Crosstalk between CLL and cutaneous T-cell lymphoma: MIF-CD74 axis and dysregulated inflammatory signaling
Crosstalk between CLL and cutaneous T-cell lymphoma: MIF-CD74 axis and dysregulated inflammatory signaling Open
View article: Tunlametinib for NRAS-mutated pediatric melanoma arising from a giant congenital melanocytic nevus: A rapidly progressive case
Tunlametinib for NRAS-mutated pediatric melanoma arising from a giant congenital melanocytic nevus: A rapidly progressive case Open
View article: Sex-Specific Survival in Advanced Metastatic Melanoma – a Decog Study on 2032 Patients of the Multicenter Prospective Skin Cancer Registry Adoreg
Sex-Specific Survival in Advanced Metastatic Melanoma – a Decog Study on 2032 Patients of the Multicenter Prospective Skin Cancer Registry Adoreg Open
View article: The Effect of <scp>NiTi</scp> Brush, Polishing Brush, and Chemical Agent on the Dental Implant Surface Morphology and Cytocompatibility
The Effect of <span>NiTi</span> Brush, Polishing Brush, and Chemical Agent on the Dental Implant Surface Morphology and Cytocompatibility Open
Objectives To in vitro investigate the effect of different implant surface decontamination methods and treatment storing conditions on implant surface morphology and cell viability. Materials and Methods Titanium disks with a sand‐blasted …
View article: Intratumoural programmed cell death protein expression in 92 patients with atypical fibroxanthoma and pleomorphic dermal sarcoma
Intratumoural programmed cell death protein expression in 92 patients with atypical fibroxanthoma and pleomorphic dermal sarcoma Open
View article: Update Merkel-Zell-Karzinom
Update Merkel-Zell-Karzinom Open
View article: Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature
Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature Open
Background Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma (CTCL). Comprehensive analysis of MF cells in situ and ex vivo is complicated by the fact that is challenging to distinguish malignant from reactive …
View article: Introducing MCC-PS: a novel prognostic score for Merkel cell carcinoma
Introducing MCC-PS: a novel prognostic score for Merkel cell carcinoma Open
Introduction Merkel cell carcinoma (MCC) is an aggressive skin cancer with a poor prognosis, which only improved with the introduction of immunotherapies. An MCC prediction model with high diagnostic accuracy is lacking. The aim was to dev…