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View article: Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality Open
Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyt…
View article: Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism
Fat‐associated lymphoid clusters: Supporting visceral adipose tissue B cell function in immunity and metabolism Open
Summary It is now widely understood that visceral adipose tissue (VAT) is a highly active and dynamic organ, with many functions beyond lipid accumulation and storage. In this review, we discuss the immunological role of this tissue, under…
View article: #2069 Elucidating the function of novel Arg1+/Clec4d+ scar-associated monocyte-derived macrophage population in driving fibrosis in kidney disease models
#2069 Elucidating the function of novel Arg1+/Clec4d+ scar-associated monocyte-derived macrophage population in driving fibrosis in kidney disease models Open
Background and Aims Fibrosis is the final common pathway in all progressive kidney disease. Macrophages are a major myeloid cell component of the renal mononuclear phagocyte system, with roles in defence against infection, renal injury, an…
View article: Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection
Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection Open
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-42918-8, published online 03 November 2023.
View article: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection Open
In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue (scWAT) and harbours a pool of parasites that are proposed to be competent for forward transmission. The interaction between parasites, adipose tissue, and the…
View article: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection Open
In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue (WAT) and harbours a pool of parasites competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is li…
View article: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection Open
In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue (WAT) and harbours a pool of parasites competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is li…
View article: FRC-derived retinoic acid: The key to unlocking milky spots
FRC-derived retinoic acid: The key to unlocking milky spots Open
Milky spots of the omentum enable lymphocyte access to the peritoneal cavity. In this issue of JEM, Yoshihara and Okabe (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221813) demonstrate how secretion of retinoic acid by fibroblastic ret…
View article: Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction
Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction Open
Background Mechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little direct …
View article: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection Open
Summary In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue (scWAT) and harbours a pool of parasites that are proposed to be competent for forward transmission. The interaction between parasites, adipose tissue,…
View article: Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum
Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum Open
The relationship between macrophages of the peritoneal cavity and the adjacent omentum remains poorly understood. Here, we describe two populations of omental macrophages distinguished by CD102 expression and use an adoptive cell transfer …
View article: Turning on ILC2s: diet control
Turning on ILC2s: diet control Open
New research by Fali and colleagues shows that peroxisome proliferator-activated receptor gamma is a central metabolic regulator of group 2 innate lymphoid cells, controlling the functional activation of these potent innate immune initiato…
View article: Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease Open
Significance Statement The innate immune system is central to injury and repair in the kidney, but the heterogeneity of myeloid cell subsets behind these processes is unknown. Complementary technologies—including bulk tissue transcriptomic…
View article: Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages
Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages Open
Peritoneal macrophages exhibit sexually dimorphic transcriptional profiles, functional capacity, and replenishment kinetics.
View article: Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease
Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease Open
The kidney has a limited capacity to repair following injury, however, the endogenous reparative pathways are not well understood. Here we employ integrated droplet- and plate-based scRNA-seq in the murine reversible unilateral ureteric ob…
View article: FALC stromal cells define a unique immunological niche for the surveillance of serous cavities
FALC stromal cells define a unique immunological niche for the surveillance of serous cavities Open
The serous cavities contain specialised adipose tissues which house small clusters of immune cells known as fat-associated lymphoid clusters (FALCs). The continuous flow of fluid from the serous cavities through FALCs makes them unique nic…
View article: Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction
Refining the Mouse Subtotal Nephrectomy in Male 129S2/SV Mice for Consistent Modeling of Progressive Kidney Disease With Renal Inflammation and Cardiac Dysfunction Open
Chronic kidney disease (CKD) is prevalent worldwide and is associated with significant co-morbidities including cardiovascular disease (CVD). Traditionally, the subtotal nephrectomy (remnant kidney) experimental model has been performed in…
View article: Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages
Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages Open
Macrophages reside in the body cavities where they maintain serosal homeostasis and provide immune surveillance. Peritoneal macrophages are implicated in the aetiology of pathologies including peritonitis, endometriosis and metastatic canc…
View article: The pericardium promotes cardiac repair and remodelling post-myocardial infarction
The pericardium promotes cardiac repair and remodelling post-myocardial infarction Open
The pericardium is widely recognised for its lubricating and bio-mechanical properties. It also contains fat-associated lymphoid clusters (FALCs) and its immune functions have been widely overlooked. Here we aimed to assess the inflammator…
View article: Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum
Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum Open
The omentum is a visceral adipose tissue rich in fat-associated lymphoid clusters (FALCs), which collects peritoneal contaminants and provides a first layer of immunological defence within the abdomen. Using single-cell RNA sequencing and …
View article: Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction
Eosinophil deficiency promotes aberrant repair and adverse remodelling following acute myocardial infarction Open
Background Eosinophil count predicts outcome following myocardial infarction (MI) and eosinophils regulate tissue repair and regeneration in extra-cardiac settings. Objectives To investigate the role of eosinophils in regulating inflammati…
View article: Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo
Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo Open
Human adenovirus 5 (HAdV-5) is used as a vector in gene therapy clinical trials, hence its interactions with the host immune system have been widely studied. Previous studies have demonstrated that HAdV-5 binds specifically to murine coagu…
View article: ILC2 orchestration of local immune function in adipose tissue:ILC2 orchestration of immune adipose function
ILC2 orchestration of local immune function in adipose tissue:ILC2 orchestration of immune adipose function Open
ILC2s were originally identified as IL-5 and IL-13 secreting ‘natural helper cells’ present within the fat associated lymphoid clusters of the mesenteries in both mouse and man. The presence of ILCs in adipose tissue has more recently expa…