Christine M. Bojanowski

Interleukin-22 and interleukin-22 binding protein signaling axis influences intubation status in trauma Open

Augustus Anderson, Jacob Broome, Aaron L. Albuck, M. Shenk, Valeria Noguera , et al. · 2025

Interleukin-22 may serve as a biomarker for trauma-induced respiratory failure, with lower levels associated with greater injury severity and the need for intubation. Further studies are needed to explore its potential as a therapeutic and…

Mutational signature analysis predicts bacterial hypermutation and multidrug resistance Open

Kalen M. Hall, Leonard G. Williams, Richard D. Smith, Erin A. Kuang, Robert K. Ernst , et al. · 2025

Bacteria of clinical importance, such as Pseudomonas aeruginosa, can become hypermutators upon loss of DNA mismatch repair (MMR) and are clinically correlated with high rates of multidrug resistance (MDR). Here, we demonstrate that hypermu…

IL-22Ra2 Levels Remain Elevated in People with Cystic Fibrosis despite Modulator Therapy Open

Christine M. Bojanowski, Stella E. Lee, Giraldina Trevejo-Nuñez, Jennifer M. Bomberger, R.P. Schleimer , et al. · 2024

"IL-22Ra2 Levels Remain Elevated in People with Cystic Fibrosis Despite Modulator Therapy." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.

Mutational signature analysis predicts bacterial hypermutation and multidrug resistance Open

Zachary F. Pursell, Kalen Hall, Leonard Williams, Richard D. Smith, Erin Kuang , et al. · 2024

Bacteria of clinical importance, such as Pseudomonas aeruginosa, can become hypermutators upon loss of DNA mismatch repair (MMR) and are clinically correlated with high rates of multidrug resistance (MDR). Here, we demonstrate that hypermu…

Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19 Open

Stephen J. Balevic, Daniel K. Benjamin, William G. Powderly, P. Brian Smith, Daniel González , et al. · 2024

Importance The pharmacokinetics of abatacept and the association between abatacept exposure and outcomes in patients with severe COVID-19 are unknown. Objective To characterize abatacept pharmacokinetics, relate drug exposure with clinical…

2769. Treatment of Hypermutator <i>Pseudomonas aeruginosa</i> Induces Multidrug Resistance but Can Be Targeted by Combination Therapy Open

Kalen M. Hall, William C. Wimley, Christine M. Bojanowski, Zachary F. Pursell, Lisa A. Morici · 2023

Background Up to 60% of Pseudomonas aeruginosa (Pa) strains isolated from human chronic lung infections lack an active DNA mismatch repair (MMR) system, resulting in a hypermutator phenotype. Hypermutator Pa isolates are associated with en…

2167. Mutational Signature Analysis to Predict Drug-resistant <i>Pseudomonas aeruginosa</i> Open

Kalen M. Hall, Leonard G. Williams, Christine M. Bojanowski, Zachary F. Pursell, Lisa A. Morici · 2023

Background Pseudomonas aeruginosa (Pa) is one of the predominant bacteria that contributes to chronic respiratory infection, patient morbidity, and mortality in cystic fibrosis (CF) patients. Up to 60% of Pa clinical isolates are hypermuta…

Aberrant immune programming in neutrophils in cystic fibrosis Open

Yawen Hu, Christine M. Bojanowski, Clemente J. Britto, Dianne Wellems, Kejing Song , et al. · 2023

Cystic fibrosis is a life-shortening genetic disorder, caused by mutations in the gene that encodes cystic fibrosis transmembrane-conductance regulator, a cAMP-activated chloride and bicarbonate channel. Persistent neutrophilic inflammatio…

Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia Open

Jane A. O’Halloran, Emily R. Ko, Kevin J. Anstrom, Eyal Kedar, Matthew W. McCarthy , et al. · 2023

Importance Immune dysregulation contributes to poorer outcomes in COVID-19. Objective To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia. Design, Setting, and P…

An ALARMINg Type 2 Response in Cystic Fibrosis—The Key to Understanding ABPA? Open

Christine M. Bojanowski, Jacob P. Bitoun, Jay K. Kolls · 2023

"An ALARMINg Type 2 Response in Cystic Fibrosis – The Key to Understanding ABPA?." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp. –

ABERRANT IMMUNE PROGRAMMING IN NEUTROPHILS IN CYSTIC FIBROSIS Open

Yawen Hu, Christine M. Bojanowski, Clemente J. Britto, Dianne Wellems, Kejing Song , et al. · 2023

Cystic fibrosis (CF) is a life-shortening genetic disorder, caused by mutations in the gene that encodes Cystic Fibrosis Transmembrane-conductance Regulator (CFTR), a cAMP-activated chloride and bicarbonate channel. Although multiple organ…

Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples Open

Wenshu Zheng, Sylvia M. LaCourse, Bofan Song, Dhiraj Kumar Singh, Mayank Khanna , et al. · 2022

Sensitive and specific blood-based assays for the detection of pulmonary and extrapulmonary tuberculosis would reduce mortality associated with missed diagnoses, particularly in children. Here we report a nanoparticle-enhanced immunoassay …

Inflammatory pseudotumor mimicking chronic pulmonary embolism or pulmonary artery sarcoma: Report of five cases Open

Xiaoyan Liao, Christine M. Bojanowski, Andrew Yen, Kim M. Kerr, Justin Dumouchel , et al. · 2021

Inflammatory pseudotumor (IPT), also known as plasma cell granuloma, is a rare lesion of unknown etiology that occurs in many organs, especially in the lung. Here we report five cases of IPT arising in pulmonary artery mimicking chronic th…

Mucosal Immunity in Cystic Fibrosis Open

Christine M. Bojanowski, Shiping Lu, Jay K. Kolls · 2021

The highly complex and variable genotype–phenotype relationships observed in cystic fibrosis (CF) have been an area of growing interest since the discovery of the CF transmembrane conductance regulator (CFTR) gene >30 y ago. The consist…

Inflammatory phenotype modulation in the respiratory tract and systemic circulation of e-cigarette users: a pilot study Open

Ibrahim M. Sayed, Jorge A. Masso-Silva, Ankita Mittal, Arjun Patel, Erica Lin , et al. · 2021

Over 40 million people use e-cigarettes worldwide, but the impact of chronic e-cigarette use on health has not been adequately defined. In particular, effects of e-cigarette aerosol inhalation on inflammation and host defenses across the b…

The effect of race, socioeconomic status, and comorbidity on patients afflicted with COVID 19: A Local Perspective Open

Nicholas Mankowski, Zaid Al‐Qurayshi, Spenser S. Souza, Brett Campbell, Adam Beighley , et al. · 2021

Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma Open

Bo Ning, Zhen Huang, Brady M. Youngquist, John W. Scott, Alex Niu , et al. · 2021

Compositional Differences in the Oral Microbiome of E-cigarette Users Open

Jessica Chopyk, Christine M. Bojanowski, John H. Shin, Alexander Moshensky, Ana Lucia Fuentes , et al. · 2021

Electronic (e)-cigarettes have been advocated as a safer alternative to conventional tobacco cigarettes. However, there is a paucity of data regarding the impact of e-cigarette aerosol deposition on the human oral microbiome, a key compone…

Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2 Open

Jorge A. Masso-Silva, Alexander Moshensky, John H. Shin, Jarod Olay, Sedtavut Nilaad , et al. · 2021

Conventional smoking is known to both increase susceptibility to infection and drive inflammation within the lungs. Recently, smokers have been found to be at higher risk of developing severe forms of coronavirus disease 2019 (COVID-19). E…

Decreased Immunomodulatory and Inflammatory Cytokines in the Saliva of Healthy Electronic Cigarette Vapers Open

Anuj Mittal, J.A. Masso Silva, Ibrahim M. Sayed, Arjun Patel, Alexander Moshensky , et al. · 2021

GM-CSF Is Elevated in the Airways of Healthy E-Cigarette Users Open

Arjun Patel, J.A. Masso Silva, Ibrahim M. Sayed, Anuj Mittal, Alexander Moshensky , et al. · 2021

Elevations in Pro-Inflammatory Chemokines in the Circulation of Healthy, Young, E-cigarette Users Open

Erica Lin, Arjun Patel, Anuj Mittal, Ibrahim M. Sayed, Alexander Moshensky , et al. · 2021

An International Virtual COVID-19 Critical Care Training Forum for Healthcare Workers Open

A. Cypro, W. Cameron McGuire, Mark Rolfsen, Neal Jones, Nirav G. Shah , et al. · 2021

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic resulted in redeployment of non-critical care-trained providers to intensive care units across the world. Concurrently, traditional venues for del…

E-cigarettes and health risks: more to the flavor than just the name Open

Miranda P. Ween, Alexander Moshensky, Leigh Thredgold, Nicole A. Bastian, Rhys Hamon , et al. · 2020

The growing interest in regulating flavored E-liquids must incorporate understanding of the “flavoring profile” of each E-liquid—which flavorings (flavoring chemicals) are present and at what concentrations not just focusing on the flavor …

Metabolic Syndrome and COVID-19 Mortality among Adult Black Patients in New Orleans Open

John Xie, Yuanhao Zu, Ala Alkhatib, Thaidan Pham, Frances M. Gill , et al. · 2020

OBJECTIVE Coronavirus disease 2019 (COVID-19) mortality is high in patients with hypertension, obesity and diabetes mellitus. We examined the association between hypertension, obesity and diabetes, individually and clustered as meta…

Metabolic Syndrome and COVID-19 Mortality among Adult Black Patients in New Orleans Open

John Xie, Yuanhao Zu, Ala Alkhatib, Thaidan Pham, Frances M. Gill , et al. · 2020

OBJECTIVE Coronavirus disease 2019 (COVID-19) mortality is high in patients with hypertension, obesity and diabetes mellitus. We examined the association between hypertension, obesity and diabetes, individually and clustered as meta…

Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans Open

John Xie, Yuanhao Zu, Ala Alkhatib, Thaidan Pham, Frances Gill , et al. · 2020

OBJECTIVE Coronavirus disease 2019 (COVID-19) mortality is high in patients with hypertension, obesity, and diabetes. We examined the association between hypertension, obesity, and diabetes, individually and clustered as metabolic syndrome…

BMI is Associated with Coronavirus Disease 2019 Intensive Care Unit Admission in African Americans Open

Ala Alkhatib, Jonah Susser Kreniske, Jerry S. Zifodya, Vivian Fonseca, Mohammad Tahboub , et al. · 2020

Objective Coronavirus disease 2019 (COVID‐19) has disproportionately impacted the African American community. This study aims to identify the risk factors for severe COVID‐19 disease in African American patients. Methods This was a retrosp…

A Case of Disseminated Histoplasmosis Diagnosed with Endobronchial Ultrasound-Guided Fine Needle Aspiration Open

M.L. Gibbs, Christine M. Bojanowski, Bernardo Ruiz, Jaime Palomino · 2020

Interpretation of Elevated Sweat Chloride Levels: Why so Salty? Open

Marjorie Bateman, Mohammad Tahboub, Christine M. Bojanowski · 2020

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