Christian Brun‐Buisson
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View article: Impacts of the COVID-19 pandemic on sepsis incidence, etiology and hospitalization costs in France: a retrospective observational study
Impacts of the COVID-19 pandemic on sepsis incidence, etiology and hospitalization costs in France: a retrospective observational study Open
Background Sepsis is a serious medical condition that causes long-term morbidity and high mortality, annually affecting millions of people worldwide. The COVID-19 pandemic may have impacted its burden. Objective To estimate the impact of t…
View article: Trends in hospitalisations for lower respiratory tract infection after the COVID-19 pandemic in adults with chronic respiratory disease
Trends in hospitalisations for lower respiratory tract infection after the COVID-19 pandemic in adults with chronic respiratory disease Open
Introduction COVID-19 pandemic has modified the epidemiology of lower respiratory tract infections (LRTI), particularly in patients presenting a chronic respiratory disease (CRD). LRTI incidence substantially decreased at the start of the …
View article: Antimicrobial Resistance as Risk Factor for Recurrent Bacteremia after <i>Staphylococcus</i><i>aureus</i>, <i>Escherichia coli</i>, or <i>Klebsiella</i> spp. Community-Onset Bacteremia
Antimicrobial Resistance as Risk Factor for Recurrent Bacteremia after <i>Staphylococcus</i><i>aureus</i>, <i>Escherichia coli</i>, or <i>Klebsiella</i> spp. Community-Onset Bacteremia Open
We investigated links between antimicrobial resistance in community-onset bacteremia and 1-year bacteremia recurrence by using the clinical data warehouse of Europe's largest university hospital group in France. We included adult patients …
View article: Care pathways of sepsis survivors: sequelae, mortality and use of healthcare services in France, 2015–2018
Care pathways of sepsis survivors: sequelae, mortality and use of healthcare services in France, 2015–2018 Open
Background Individuals who survive sepsis are at high risk of chronic sequelae, resulting in significant health-economic costs. Several studies have focused on aspects of healthcare pathways of sepsis survivors but comprehensive, longitudi…
View article: Antimicrobial Resistance and Mortality in Hospitalized Patients with Bacteremia in the Greater Paris Area from 2016 to 2019
Antimicrobial Resistance and Mortality in Hospitalized Patients with Bacteremia in the Greater Paris Area from 2016 to 2019 Open
The Bacthub database provides accurate clinico-microbiological data describing bacteremia across France's largest hospital group. Data from Bacthub may inform surveillance and the clinical decision-making process for bacteremia patients, i…
View article: One-year hospital readmission for recurrent sepsis: associated risk factors and impact on 1-year mortality—a French nationwide study
One-year hospital readmission for recurrent sepsis: associated risk factors and impact on 1-year mortality—a French nationwide study Open
Background Sepsis is a complex health condition, leading to long-term morbidity and mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid- and long-term mortality among other risk factors, is essentia…
View article: Outpatient Antibiotic Prescriptions in France: Patients and Providers Characteristics and Impact of the COVID-19 Pandemic
Outpatient Antibiotic Prescriptions in France: Patients and Providers Characteristics and Impact of the COVID-19 Pandemic Open
In France, despite several successive plans to control antimicrobial resistance, antibiotic use remains high in the outpatient setting. This study aims to better understand outpatient antibiotic use and prescription in order to identify ta…
View article: Trends in bacterial sepsis incidence and mortality in France between 2015 and 2019 based on National Health Data System (Système National des données de Santé (SNDS)): a retrospective observational study
Trends in bacterial sepsis incidence and mortality in France between 2015 and 2019 based on National Health Data System (Système National des données de Santé (SNDS)): a retrospective observational study Open
Objective This study aims to provide a case definition of sepsis of presumed bacterial aetiology based on 10th revision of the International Classification of Diseases (ICD-10) codes, to assess trends in sepsis incidence and mortality betw…
View article: From Pathophysiological Hypotheses to Case–Control Study Design: Resistance from Antibiotic Exposure in Community-Onset Infections
From Pathophysiological Hypotheses to Case–Control Study Design: Resistance from Antibiotic Exposure in Community-Onset Infections Open
Antimicrobial resistance is a global public health concern, at least partly due to the misuse of antibiotics. The increasing prevalence of antibiotic-resistant infections in the community has shifted at-risk populations into the general po…
View article: Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients
Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients Open
ClinicalTrials.gov Identifier: NCT02462590.
View article: Outpatient antibiotic use attributable to viral acute lower respiratory tract infections during the cold season in France, 2010-2017
Outpatient antibiotic use attributable to viral acute lower respiratory tract infections during the cold season in France, 2010-2017 Open
Antibiotic stewardship requires clear insight into antibiotic overuse and the syndromes that lead to prescription. The aim of this study was to estimate the proportion of antibiotic prescriptions attributable to acute lower respiratory tra…
View article: Costs and Outcomes of 1-year post-discharge care trajectories of patients admitted with infection due to antibiotic-resistant bacteria
Costs and Outcomes of 1-year post-discharge care trajectories of patients admitted with infection due to antibiotic-resistant bacteria Open
French Ministry of health.
View article: Procalcitonin to Reduce Antibiotic Exposure during Acute Chest Syndrome in Adult Patients with Sickle-Cell Disease
Procalcitonin to Reduce Antibiotic Exposure during Acute Chest Syndrome in Adult Patients with Sickle-Cell Disease Open
Acute chest syndrome (ACS) is a major complication of sickle-cell disease. Bacterial infection is one cause of ACS, so current guidelines recommend the routine use of antibiotics. We performed a prospective before–after study in medical wa…
View article: Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review
Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review Open
Selective decontamination of the digestive tract (SDD) is an infection prevention measure for intensive care unit (ICU) patients that was proposed more than 30 years ago, and that is currently considered standard of care in the Netherlands…
View article: Hospitalisations with infections related to antimicrobial-resistant bacteria from the French nationwide hospital discharge database, 2016
Hospitalisations with infections related to antimicrobial-resistant bacteria from the French nationwide hospital discharge database, 2016 Open
Massive use of antibiotics has led to increased bacterial resistance to these drugs, making infections more difficult to treat. Few studies have assessed the overall antimicrobial resistance (AMR) burden, and there is a paucity of comprehe…
View article: A Payer Perspective of the Hospital Inpatient Additional Care Costs of Antimicrobial Resistance in France: A Matched Case–Control Study
A Payer Perspective of the Hospital Inpatient Additional Care Costs of Antimicrobial Resistance in France: A Matched Case–Control Study Open
AMR causes substantial cost burden in France for the public health insurance. Our study confirms the need to reinforce programs to prevent AMR infection and thereby reduce their economic burden.
View article: Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients
Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients Open
ClinicalTrials.gov Identifier: NCT02208154.