Cihan Ay
YOU?
Author Swipe
View article: From efficacy to experience: 52-week patient-reported outcomes with Mim8 in adolescents and adults with hemophilia A with or without inhibitors (FRONTIER2)
From efficacy to experience: 52-week patient-reported outcomes with Mim8 in adolescents and adults with hemophilia A with or without inhibitors (FRONTIER2) Open
Introduction Mim8 is a new-generation, bispecific antibody, activated factor VIII mimetic in clinical development for subcutaneous prophylaxis (PPX) in hemophilia A (HA) with or without factor VIII inhibitors. The phase 3 FRONTIER2 study (…
View article: HTRS2025.O8C.1 Investigating Multifaceted Patient-Reported Benefits of Mim8 Prophylaxis Beyond Bleeding Outcomes for Hemophilia A: Results From the FRONTIER2 Study
HTRS2025.O8C.1 Investigating Multifaceted Patient-Reported Benefits of Mim8 Prophylaxis Beyond Bleeding Outcomes for Hemophilia A: Results From the FRONTIER2 Study Open
View article: Mechanisms and treatment of venous thromboembolism in patients with brain cancer: a narrative review
Mechanisms and treatment of venous thromboembolism in patients with brain cancer: a narrative review Open
Malignant brain tumors, including both primary brain cancer and metastatic brain cancer, are associated with a markedly increased risk of venous thromboembolism (VTE). Anticoagulation is challenging in this population, as these patients ar…
View article: HTRS2025.O8C.5 Phase I Study of VGA039 in Individuals with Von Willebrand Disease Demonstrates Sustained Drug Concentrations, Increased Thrombin Generation, and Decreased Bleeding After Single Subcutaneous Injection
HTRS2025.O8C.5 Phase I Study of VGA039 in Individuals with Von Willebrand Disease Demonstrates Sustained Drug Concentrations, Increased Thrombin Generation, and Decreased Bleeding After Single Subcutaneous Injection Open
View article: HTRS2025.P2.80 Phase 3 Study of a Double Virus-Inactivated Human Antithrombin Concentrate During Surgery or Childbirth in Patients with Congenital Antithrombin Deficiency
HTRS2025.P2.80 Phase 3 Study of a Double Virus-Inactivated Human Antithrombin Concentrate During Surgery or Childbirth in Patients with Congenital Antithrombin Deficiency Open
View article: Venous thromboembolic event risk with PARP inhibitors in solid tumors: a systematic review and meta-analysis
Venous thromboembolic event risk with PARP inhibitors in solid tumors: a systematic review and meta-analysis Open
While our findings indicate a possible association between PARPi and VTE risk in certain cancer types, this risk appears to be influenced by factors such as cancer subtype and treatment combinations. The overall contribution of PARPi monot…
View article: Epigenetic Aging Signatures in People with Hemophilia
Epigenetic Aging Signatures in People with Hemophilia Open
Hemophilia is a rare X-linked bleeding disorder leading to recurrent hemarthroses, hemophilic arthropathy, and impaired quality of life. A chronic lifelong disease, hemophilia might be associated with accelerated biological aging. Here, we…
View article: The Presence of Neutrophil Extracellular Traps (NETs) in Brain Tumor Vessels Is Linked to Platelet Aggregates and Podoplanin in the Tumor Microenvironment
The Presence of Neutrophil Extracellular Traps (NETs) in Brain Tumor Vessels Is Linked to Platelet Aggregates and Podoplanin in the Tumor Microenvironment Open
Background: Multiple mechanisms might lead to cancer-related hypercoagulability. In brain tumors, podoplanin, via its ability to activate platelets, seems to play a crucial role in developing venous thromboembolism (VTE). Different stimuli…
View article: A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism
A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism Open
View article: Walking capacity and venous claudication after deep vein thrombosis: prospective follow-up, risk factors, and quality of life
Walking capacity and venous claudication after deep vein thrombosis: prospective follow-up, risk factors, and quality of life Open
View article: Large language models vs thrombosis experts: a comparative study on patient education and clinical decision-making in venous thromboembolism
Large language models vs thrombosis experts: a comparative study on patient education and clinical decision-making in venous thromboembolism Open
LLMs outperform experts in venous thromboembolism-related patient education and match or exceed them in clinical decision making, providing responses indistinguishable from experts. Although major barriers need to be addressed, LLMs have s…
View article: Podoplanin expression is associated with local inflammation and survival in glioma
Podoplanin expression is associated with local inflammation and survival in glioma Open
View article: Variation in Venous Thromboembolism Outcomes Based on Primary Cancer Site
Variation in Venous Thromboembolism Outcomes Based on Primary Cancer Site Open
VTE and bleeding risks in cancer-associated thrombosis vary substantially by cancer site. These findings support a personalized approach to anticoagulation in cancer patients with VTE.
View article: External validation of the VTE-PREDICT score for predicting recurrence and bleeding in venous thromboembolism: results from the Registro Informatizado Enfermedad TromboEmbὀlica Registry
External validation of the VTE-PREDICT score for predicting recurrence and bleeding in venous thromboembolism: results from the Registro Informatizado Enfermedad TromboEmbὀlica Registry Open
VTE-PREDICT showed good discrimination for VTE recurrence and moderate discrimination for CRB, but underestimated the risk of VTE recurrence in high-risk patients.
View article: Arterial and venous thromboembolic events in patients with cancer treated with targeted therapies: a population-based cohort study
Arterial and venous thromboembolic events in patients with cancer treated with targeted therapies: a population-based cohort study Open
View article: Antibodies to oxidation-specific epitopes characterize hemodialysis patients protected from cardiovascular events
Antibodies to oxidation-specific epitopes characterize hemodialysis patients protected from cardiovascular events Open
Natural autoantibodies against OSEs were not associated with the overall risk of 3P-MACE in this cohort of HD patients. However, we found that long-term survivors had higher levels of natural autoantibodies against OSEs.
View article: Prevention and treatment of venous thromboembolism in patients with multiple myeloma: Clinical practice guidelines on behalf of the European Myeloma Network
Prevention and treatment of venous thromboembolism in patients with multiple myeloma: Clinical practice guidelines on behalf of the European Myeloma Network Open
Venous thromboembolism (VTE) is a frequent complication in patients with multiple myeloma (MM) that leads to increased morbidity, mortality, treatment interruptions, and reduced quality of life. Αn Expert Panel Consensus Guideline on behal…
View article: Thromboembolism and bleeding in newly diagnosed multiple myeloma: rates, risk profile, and patterns of thromboprophylaxis
Thromboembolism and bleeding in newly diagnosed multiple myeloma: rates, risk profile, and patterns of thromboprophylaxis Open
We observed a high rate of VTE and bleeding in patients with newly diagnosed MM. Use of anticoagulant therapy including direct oral anticoagulants was associated with a trend toward reduced risk of VTE compared with aspirin or no antithrom…
View article: Prevalence of iron deficiency in patients with mild to moderate bleeding disorders and bleeding disorder of unknown cause
Prevalence of iron deficiency in patients with mild to moderate bleeding disorders and bleeding disorder of unknown cause Open
ID was common among MBDs, especially von Willebrand disease and female patients, but also in controls. Our data highlight the importance of assessing iron status in patients with MBDs, especially in young female individuals, regardless of …
View article: Altered platelet lipidome in bleeding patients with unexplained platelet function defects
Altered platelet lipidome in bleeding patients with unexplained platelet function defects Open
In patients with a mild to moderate bleeding disorder (MBD) and abnormal light transmission aggregometry (LTA), a platelet function defect (PFD) is suspected. However, in many patients with PFD, the underlying mechanism remains elusive. Gi…
View article: Estimating the Factor VIII‐Equivalent Activity of Emicizumab Using Global Assays of Haemostasis
Estimating the Factor VIII‐Equivalent Activity of Emicizumab Using Global Assays of Haemostasis Open
Background Emicizumab is a bispecific monoclonal antibody mimicking factor (F) VIII activity and an effective therapy for prophylaxis in people with haemophilia A (PWHA). The FVIII‐equivalent activity (FVIIIeq) of emicizumab remains unknow…
View article: Corrigendum: Management of Cancer-Associated Thrombosis: Unmet Needs and Future Perspectives
Corrigendum: Management of Cancer-Associated Thrombosis: Unmet Needs and Future Perspectives Open
[This corrects the article DOI: 10.1055/s-0041-1736037.].
View article: Clinical evidence for antiglycoprotein IIbIIIa antibody-induced platelet desialylation in primary immune thrombocytopenia
Clinical evidence for antiglycoprotein IIbIIIa antibody-induced platelet desialylation in primary immune thrombocytopenia Open
View article: Impaired surface receptor expression on immature platelets in bleeding patients with abnormal light transmission aggregometry
Impaired surface receptor expression on immature platelets in bleeding patients with abnormal light transmission aggregometry Open
This study demonstrates significant alterations in surface receptor expression on immature platelets in patients with suspected PFD, underscoring immature platelets as crucial link to platelet biology and clinical symptoms in this patient …
View article: Ascites of patients with solid tumors shows distinct inflammatory patterns
Ascites of patients with solid tumors shows distinct inflammatory patterns Open
View article: Clonal hematopoiesis in patients with cancer and its association with risk of thrombosis and prognosis of disease
Clonal hematopoiesis in patients with cancer and its association with risk of thrombosis and prognosis of disease Open
In our cohort of patients with cancer, the presence of CH was not associated with an increased risk of VTE or ATE. CH had no independent impact on overall survival.
View article: Longitudinal dynamics of hemostatic biomarkers in patients with cancer receiving immune checkpoint inhibitors vs chemotherapy: results from the Vienna CAT-BLED study
Longitudinal dynamics of hemostatic biomarkers in patients with cancer receiving immune checkpoint inhibitors vs chemotherapy: results from the Vienna CAT-BLED study Open
View article: Bleeding risk and performance of bleeding risk assessment models in patients with venous thromboembolism on anticoagulation: results from the prospective observational bleeding and assess long-term outcomes on health in patients with venous thromboembolism (BACH-VTE) study
Bleeding risk and performance of bleeding risk assessment models in patients with venous thromboembolism on anticoagulation: results from the prospective observational bleeding and assess long-term outcomes on health in patients with venous thromboembolism (BACH-VTE) study Open
In patients treated with anticoagulants for VTE, we found high rates of CRB. Only the VTE-PREDICT model showed acceptable discrimination, but poor calibration.
View article: Clonal Hematopoiesis and Thrombosis
Clonal Hematopoiesis and Thrombosis Open
Clonal hematopoiesis (CH) has been the focus of many research efforts in the last years and has emerged as a risk modifier for cardiovascular disease morbidity and mortality. While substantial evidence has accumulated regarding its impact …
View article: Hemostatic and Inflammatory Biomarkers are Associated with Functional Limitations after Venous Thromboembolism: A Prospective Cohort Study
Hemostatic and Inflammatory Biomarkers are Associated with Functional Limitations after Venous Thromboembolism: A Prospective Cohort Study Open
Functional limitations often persist in patients with venous thromboembolism (VTE). The relevance of biomarkers for these outcomes remains unexplored. Therefore, we aimed to investigate the association of hemostatic, inflammatory, and card…