Jean‐Christoph Caubet
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View article: Drug hypersensitivity reactions in children in clinical practice: A WAO Statement
Drug hypersensitivity reactions in children in clinical practice: A WAO Statement Open
Drug hypersensitivity reactions (DHRs) in children and adolescents are less common than in adults but can have serious consequences if mismanaged. Mislabeling children as drug-allergic due to incomplete diagnostic evaluations leads to unne…
View article: Cow's milk protein allergy with protein‐losing enteropathy under the scope
Cow's milk protein allergy with protein‐losing enteropathy under the scope Open
Objectives Cow's milk protein allergy (CMPA) is very frequent in infants. Presentation is variable, and symptoms fluctuate in intensity. Diagnosis can be challenging as it is mostly clinical. In severe cases, patients can present with anas…
View article: Clinical diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) in children: An EAACI position paper
Clinical diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) in children: An EAACI position paper Open
Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe cutaneous adverse drug reaction encountered in both adults and children with a significant mortality rate. A number of guidelines or consensus re…
View article: Evaluation of peanut tolerance in sensitized mice through intradermal allergen delivery with adjuvants
Evaluation of peanut tolerance in sensitized mice through intradermal allergen delivery with adjuvants Open
Peanut allergy is a significant worldwide health issue and requires innovative approaches to provide safer and more effective treatments. This study explores the potential of intradermal immunotherapy using peanut formulations combined wit…
View article: CLINICAL DIAGNOSIS AND MANAGEMENT OF DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS(DRESS) IN CHILDREN: AN EAACI POSITION PAPER
CLINICAL DIAGNOSIS AND MANAGEMENT OF DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS(DRESS) IN CHILDREN: AN EAACI POSITION PAPER Open
View article: Working with companies that manufacture breastmilk substitutes: An EAACI position paper
Working with companies that manufacture breastmilk substitutes: An EAACI position paper Open
Breastmilk is the optimal source of nutrition for infants and should ideally be provided exclusively for the first 6 months of life, and alongside complementary food until 2 years of life. However, there are circumstances where a breastmil…
View article: The importance of clinical history in the diagnosis of drug hypersensitivity in children
The importance of clinical history in the diagnosis of drug hypersensitivity in children Open
Background In case of suspected hypersensitivity reactions (HRs) to drugs, a challenging area for pediatricians is detecting relevant elements in the parent‐reported history, in order to reach a definite diagnosis. We analyzed the concorda…
View article: The severity of allergic reactions in a real-world environment is independent of the eliciting amounts of foods.
The severity of allergic reactions in a real-world environment is independent of the eliciting amounts of foods. Open
Introduction Patients with food allergies necessite having personalized information on their risk of reaction in “real-life” situations. This multicentric study aimed to investigate the link during accidental reactions between the nature a…
View article: Prolonged drug provocation with an initial full therapeutic dose to diagnose serum sickness-like reactions (SSLR) to β-lactams in children
Prolonged drug provocation with an initial full therapeutic dose to diagnose serum sickness-like reactions (SSLR) to β-lactams in children Open
Prolonged drug provocation with an initial full therapeutic dose to diagnose serum sickness-like reactions (SSLR) to β-lactams in childrenMarcel M Bergmanna,b,c, Eva Gomesd, Natalia Blanca-Lópeze, Jean-Christoph Caubeta, Philippe A Eigenma…
View article: Real‐life evaluation of tolerance to foods with precautionary allergen labeling in children with <scp>IgE</scp>‐mediated food allergy
Real‐life evaluation of tolerance to foods with precautionary allergen labeling in children with <span>IgE</span>‐mediated food allergy Open
Precautionary allergen labeling (PAL) statements on packaged food products such as “may contain” are confusing and are ignored by up to 40% of consumers with food allergies.1, 2 However, there is very little real-life data assessing the ri…
View article: <scp>EAACI</scp>Molecular Allergology User's Guide 2.0
<span>EAACI</span>Molecular Allergology User's Guide 2.0 Open
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response…
View article: Clinical and immunological data from chronic urticaria onset after mRNA SARS‐CoV‐2 vaccines
Clinical and immunological data from chronic urticaria onset after mRNA SARS‐CoV‐2 vaccines Open
The Swiss regulatory agency approved BNT 162b2 from Pfizer-BioNTech and mRNA-1273 from Moderna in December 2020 and January 2021, respectively. A third vaccine dose (booster) was recommended by the end of October 2021. Although the vast ma…
View article: Simplifying the drug provocation test in non‐immediate hypersensitivity reactions to amoxicillin in children: The experience of a tertiary care allergy unit
Simplifying the drug provocation test in non‐immediate hypersensitivity reactions to amoxicillin in children: The experience of a tertiary care allergy unit Open
Background Mild non‐immediate reactions (NIR) to beta‐lactams (βLs) are the most common manifestation of adverse drug reactions in children, and the drug provocation test (DPT) remains the gold standard for diagnosis. However, there are st…
View article: Standards for practical intravenous rapid drug desensitization & delabeling: A WAO committee statement
Standards for practical intravenous rapid drug desensitization & delabeling: A WAO committee statement Open
View article: Desensitization to drugs in children
Desensitization to drugs in children Open
Better knowledge and understanding about drug desensitization is required in the pediatric population, since there is little literature available about it and the most pediatric desensitization protocols have been adapted from adult instru…
View article: Allergies and COVID‐19 vaccines: An ENDA/EAACI Position paper
Allergies and COVID‐19 vaccines: An ENDA/EAACI Position paper Open
Background Anaphylaxis, which is rare, has been reported after COVID‐19 vaccination, but its management is not standardized. Method Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunolog…
View article: COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations
COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations Open
Immune modulation is a key therapeutic tool for allergic diseases and asthma. It can be achieved in an antigen-specific way via allergen immunotherapy (AIT) or in endotype-driven approach using biologicals that target the major pathways of…
View article: Latest Developments in the Management of Nut Allergies
Latest Developments in the Management of Nut Allergies Open
View article: Management of anaphylaxis due to COVID‐19 vaccines in the elderly
Management of anaphylaxis due to COVID‐19 vaccines in the elderly Open
Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID‐19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID‐19 v…
View article: Viral Infections and Cutaneous Drug-Related Eruptions
Viral Infections and Cutaneous Drug-Related Eruptions Open
In the general population, up to 10% of children treated by antibiotics have cutaneous adverse drug reaction, but allergy is confirmed in less than 20% of patients. Most of the non-allergic reactions are probably due to virus, such as ente…
View article: Author response for "Drug‐Induced Enterocolitis Syndrome: similarities and differences compared with Food Protein‐Induced Enterocolitis Syndrome"
Author response for "Drug‐Induced Enterocolitis Syndrome: similarities and differences compared with Food Protein‐Induced Enterocolitis Syndrome" Open
View article: Recent advances in the management of nut allergy
Recent advances in the management of nut allergy Open
Peanut/tree nut allergy is common and has been associated with particularly severe reactions. Epidemiological data have shown that the prevalence ranges between 0.05% and 4.9% for tree nut and between 0.5% and 3% for peanut. These large va…
View article: Basophil Activation Test Reduces Oral Food Challenges to Nuts and Sesame
Basophil Activation Test Reduces Oral Food Challenges to Nuts and Sesame Open
View article: Delayed hypersensitivity to antiepileptic drugs in children
Delayed hypersensitivity to antiepileptic drugs in children Open
Background: Antiepileptic drugs (AEDs) are widely used for the treatment of epilepsy, but they can be associated with the development of mainly delayed/non-immediate hypersensitivity reactions (HRs). Although these reactions are usually cu…
View article: Author response for "Drug‐Induced Enterocolitis Syndrome: similarities and differences compared with Food Protein‐Induced Enterocolitis Syndrome"
Author response for "Drug‐Induced Enterocolitis Syndrome: similarities and differences compared with Food Protein‐Induced Enterocolitis Syndrome" Open
View article: Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update
Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update Open
Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPI…
View article: Managing food protein–induced enterocolitis syndrome during the coronavirus disease 2019 pandemic
Managing food protein–induced enterocolitis syndrome during the coronavirus disease 2019 pandemic Open
View article: International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology
International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology Open
Food protein-induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight int…
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View article: Author response for "Can my child with IgE‐mediated peanut allergy introduce foods labeled with “may contain traces”?"
Author response for "Can my child with IgE‐mediated peanut allergy introduce foods labeled with “may contain traces”?" Open