Chris Cheadle
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View article: Supplementary Tables S1 through S3 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Supplementary Tables S1 through S3 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Supplementary Table S1: PD-L1+ RCC specimens used in this study. Supplementary Table S2: Genes differentially expressed in RCC based on whole genome microarray analysis, in patients responding or not to anti-PD-1 therapy (234 probe sets co…
View article: Data from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Data from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Pretreatment tumor PD-L1 expression has been shown to correlate with response to anti–PD-1/PD-L1 therapies. Yet, most patients with PD-L1+ tumors do not respond to treatment. The current study was undertaken to investigate mechanisms under…
View article: Supplementary Tables S1 through S3 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Supplementary Tables S1 through S3 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Supplementary Table S1: PD-L1+ RCC specimens used in this study. Supplementary Table S2: Genes differentially expressed in RCC based on whole genome microarray analysis, in patients responding or not to anti-PD-1 therapy (234 probe sets co…
View article: Data from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Data from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Pretreatment tumor PD-L1 expression has been shown to correlate with response to anti–PD-1/PD-L1 therapies. Yet, most patients with PD-L1+ tumors do not respond to treatment. The current study was undertaken to investigate mechanisms under…
View article: Supplementary Materials and Methods from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Supplementary Materials and Methods from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Supplementary Materials and Methods
View article: Supplementary Figures S1 through S4 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Supplementary Figures S1 through S4 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Figure S1: Extraction of paraffin-embedded PD-L1+ RCC tissues for RNA isolation. Figure S2: Molecules previously found to be up-regulated in PD-L1+ vs. PD-L1(-) melanomas are not differentially expressed in PD-L1+ RCCs from patients with d…
View article: Supplementary Figures S1 through S4 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Supplementary Figures S1 through S4 from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Figure S1: Extraction of paraffin-embedded PD-L1+ RCC tissues for RNA isolation. Figure S2: Molecules previously found to be up-regulated in PD-L1+ vs. PD-L1(-) melanomas are not differentially expressed in PD-L1+ RCCs from patients with d…
View article: Supplementary Materials and Methods from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma
Supplementary Materials and Methods from The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti–PD-1 Response in Patients with Renal Cell Carcinoma Open
Supplementary Materials and Methods
View article: Supplementary Table S2 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Table S2 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary Table S2: 1660 Illumina probes up-regulated at least 2-fold in PD-L1+ melanomas
View article: Supplementary Table S1, Supplementary Table S3, Supplementary Table S5 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Table S1, Supplementary Table S3, Supplementary Table S5 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary Table S1, Supplementary Table S3, Supplementary Table S5. Supplementary Table S1: Genes selected for multiplex qRT-PCR array Supplementary Table S3: Functionally annotated gene categories from DAVID analysis of whole genome m…
View article: Data from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Data from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Purpose: Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response. We previously found …
View article: Supplementary Figures 1 - 3 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Figures 1 - 3 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Figure S1, Figure S2, Figure S3. Supplementary Figure S1: Overlay of PD-L1 and LAG-3 IHC demonstrates close geographic association of these cell-surface markers in a melanoma lymph node metastasis. Supplementary Figure S2: Comparison of im…
View article: Supplementary Table S1, Supplementary Table S3, Supplementary Table S5 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Table S1, Supplementary Table S3, Supplementary Table S5 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary Table S1, Supplementary Table S3, Supplementary Table S5. Supplementary Table S1: Genes selected for multiplex qRT-PCR array Supplementary Table S3: Functionally annotated gene categories from DAVID analysis of whole genome m…
View article: Supplementary Table S2 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Table S2 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary Table S2: 1660 Illumina probes up-regulated at least 2-fold in PD-L1+ melanomas
View article: Supplementary methods from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary methods from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary methods
View article: Data from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Data from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Purpose: Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response. We previously found …
View article: Supplementary methods from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary methods from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary methods
View article: Supplementary Table S4 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Table S4 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary Table S4: DAVID clustering of 1660 Illumina probes up-regulated at least 2-fold in PD-L1+ melanomas
View article: Supplementary Figures 1 - 3 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Figures 1 - 3 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Figure S1, Figure S2, Figure S3. Supplementary Figure S1: Overlay of PD-L1 and LAG-3 IHC demonstrates close geographic association of these cell-surface markers in a melanoma lymph node metastasis. Supplementary Figure S2: Comparison of im…
View article: Supplementary Table S4 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Supplementary Table S4 from Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade Open
Supplementary Table S4: DAVID clustering of 1660 Illumina probes up-regulated at least 2-fold in PD-L1+ melanomas
View article: Attractor Landscapes as a Model Selection Criterion in Data Poor Environments
Attractor Landscapes as a Model Selection Criterion in Data Poor Environments Open
Modeling of systems for which data is limited often leads to underdetermined model identification problems, where multiple candidate models are equally adherent to data. In such situations additional optimality criteria are useful in model…
View article: Replicated methylation changes associated with eczema herpeticum and allergic response
Replicated methylation changes associated with eczema herpeticum and allergic response Open
We identified a CpG in IL4 associated with serum tIgE levels, supporting a role for Th2 immune mediating mechanisms in AD. Changes in eosinophil level, a measure of disease severity, are associated with methylation changes, providing a pot…
View article: Additional file 3: of Replicated methylation changes associated with eczema herpeticum and allergic response
Additional file 3: of Replicated methylation changes associated with eczema herpeticum and allergic response Open
Table S4. DMPs significant from ADEHâ vs controls and/or ADEH+ vs controls analysis at an FDR threshold of 0.05 from model adjusting for six cell types. (XLSX 91 kb)
View article: Additional file 4: of Replicated methylation changes associated with eczema herpeticum and allergic response
Additional file 4: of Replicated methylation changes associated with eczema herpeticum and allergic response Open
Tables S5â S8. DMPs significant from severity analysis to follow up on results in Additional file 3: Table S4. (XLSX 120 kb)
View article: Additional file 2: of Replicated methylation changes associated with eczema herpeticum and allergic response
Additional file 2: of Replicated methylation changes associated with eczema herpeticum and allergic response Open
Table S2 and S3. DMPs significant from gene-based analysis for both phenotype groups and severity scores. (XLSX 31 kb)
View article: Additional file 5: of Replicated methylation changes associated with eczema herpeticum and allergic response
Additional file 5: of Replicated methylation changes associated with eczema herpeticum and allergic response Open
Table S9. Gene ontology (GO) analysis results for ADEH+ vs healthy controls. (XLSX 11 kb)
View article: Comprehensive literature data-mining analysis reveals a broad genetic network functionally associated with autism spectrum disorder
Comprehensive literature data-mining analysis reveals a broad genetic network functionally associated with autism spectrum disorder Open
Previous studies have indicated that genetic factors are the predominate cause of Autism spectrum disorder (ASD). Nevertheless, to the best of our knowledge, to date no systematic study has summarized these data and provided an objective, …
View article: The genetic network underlying anxiety disorder and its small molecular level supports
The genetic network underlying anxiety disorder and its small molecular level supports Open
Background:It is believed that the genetic causes of complex diseases, such as anxiety, are linked to large genetic networks. In recent years, there has been an increased number of studies reporting hundreds of genes associated with anxiet…