Claire Chougnet
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View article: Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung
Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung Open
Introduction Early-life dysbiosis is associated with increased risk of asthma development but the underlying mechanisms remain unclear. Although eosinophils have been reported in the developing lung, their contributions to alveolar morphog…
View article: Monocyte Activation in People With HIV and Tuberculosis Coinfection and Effect of Tuberculosis Preventive Therapy: An Analysis of the ACTG A5279/BRIEF TB Trial
Monocyte Activation in People With HIV and Tuberculosis Coinfection and Effect of Tuberculosis Preventive Therapy: An Analysis of the ACTG A5279/BRIEF TB Trial Open
Background Monocyte activation contributes to the pathogenesis of inflammation-driven comorbidities in people with HIV (PWH). We investigated the impact of tuberculin skin test (TST)/interferon-γ release assay (IGRA) status and tuberculosi…
View article: Intrauterine infection causes neuroinflammation and a selective loss of immature neurons in preterm non-human primate (NHP) fetuses 3227
Intrauterine infection causes neuroinflammation and a selective loss of immature neurons in preterm non-human primate (NHP) fetuses 3227 Open
Description Epidemiological data strongly links fetal exposure to chorioamnionitis with adverse infant neurological outcomes, but mechanisms are unknown. We developed a NHP model of chorioamnionitis resulting in fetal inflammation without …
View article: IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation
IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation Open
Introduction IL6 signaling plays an important role in triggering labor and IL6 is an established biomarker of intrauterine infection/inflammation (IUI) driven preterm labor (PTL). The biology of IL6 during IUI at the maternal-fetal interfa…
View article: Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.
Cholestasis alters polarization and suppressor function of hepatic regulatory T cells. Open
Fibrosing cholangiopathies, including biliary atresia and primary sclerosing cholangitis, involve immune-mediated bile duct epithelial injury and hepatic bile acid (BA) retention (cholestasis). Regulatory T-cells (Tregs) can prevent auto-r…
View article: Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties
Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties Open
Several studies in animal models and human cohorts have recently suggested that HDLs (high-density lipoproteins) not only modulate innate immune responses but also adaptative immune responses, particularly CD4+ T cells. CD4+ T cells are ce…
View article: Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells
Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells Open
Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were shown to be highly differentiat…
View article: Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes
Apolipoprotein E-containing HDL decreases caspase-dependent apoptosis of memory regulatory T lymphocytes Open
Plasma levels of HDL cholesterol are inversely associated with CVD progression. It is becoming increasingly clear that HDL plays important roles in immunity that go beyond its traditionally understood roles in lipid transport. We previousl…
View article: BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth
BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth Open
Clinical evidence points to a function for B cell-activating factor (BAFF) in pregnancy. However, direct roles for BAFF-axis members in pregnancy have not been examined. Here, via utility of genetically modified mice, we report that BAFF p…
View article: Elevated CD153 Expression on Aged T Follicular Helper Cells is Vital for B cell Responses
Elevated CD153 Expression on Aged T Follicular Helper Cells is Vital for B cell Responses Open
Our recent data showed that an aberrant IL-10-producing T follicular helper population (Tfh10) accumulates dramatically with age and is associated with age-related declines in vaccine responsiveness. Through single cell gene expression and…
View article: An atlas of gene regulatory networks for memory CD4<sup>+</sup>T cells in youth and old age
An atlas of gene regulatory networks for memory CD4<sup>+</sup>T cells in youth and old age Open
Aging profoundly affects immune-system function, promoting susceptibility to pathogens, cancers and chronic inflammation. We previously identified a population of IL-10-producing, T follicular helper-like cells (“ Tfh10 ”), linked to suppr…
View article: Impaired response of memory Treg to high density lipoproteins is associated with intermediate/high cardiovascular disease risk in persons with HIV
Impaired response of memory Treg to high density lipoproteins is associated with intermediate/high cardiovascular disease risk in persons with HIV Open
Cardiovascular disease (CVD) is a leading cause of enhanced morbidity and mortality in persons with HIV (PWH) in the era of highly active antiretroviral therapy (AART). However, the underlying mechanisms are not fully understood. Regulator…
View article: Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice Open
Microbial maturation disrupted by early-life dysbiosis has been linked with increased asthma risk and severity; however, the immunological mechanisms underpinning this connection are poorly understood. We sought to understand how delaying …
View article: Pro-Inflammatory Alterations of Circulating Monocytes in Latent Tuberculosis Infection
Pro-Inflammatory Alterations of Circulating Monocytes in Latent Tuberculosis Infection Open
Background Latent tuberculosis infection (LTBI) has been associated with increased cardiovascular risk. We investigated the activation and pro-inflammatory profile of monocytes in individuals with LTBI and their association with coronary a…
View article: Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques
Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques Open
Accurate estimate of fetal maturity could provide individualized guidance for delivery of complicated pregnancies. However, current methods are invasive, have low accuracy, and are limited to fetal lung maturation. To identify diagnostic g…
View article: Prenatal antibiotics exposure does not influence experimental allergic asthma in mice
Prenatal antibiotics exposure does not influence experimental allergic asthma in mice Open
Changes in microbiome (dysbiosis) contribute to severity of allergic asthma. Preexisting epidemiological studies in humans correlate perinatal dysbiosis with increased long-term asthma severity. However, these studies cannot discriminate b…
View article: Single-nucleus RNA-seq reveals disrupted cell maturation by chorioamnionitis in the preterm cerebellum of nonhuman primates
Single-nucleus RNA-seq reveals disrupted cell maturation by chorioamnionitis in the preterm cerebellum of nonhuman primates Open
Preterm birth is often associated with chorioamnionitis and increased risk of neurodevelopmental disorders. Preterm birth also leads to cerebellar underdevelopment but the mechanisms of disrupted cerebellar development in preterm infants a…
View article: Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease
Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease Open
Age-associated microglial dysfunction contributes to the accumulation of amyloid-b (Ab) plaques in Alzheimer’s disease. Although several studies have shown age-related declines in the phagocytic capacity of myeloid cells, relatively few ha…
View article: The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota
The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota Open
Although modern clinical practices such as cesarean sections and perinatal antibiotics have improved infant survival, treatment with broad-spectrum antibiotics alters intestinal microbiota and causes dysbiosis. Infants exposed to perinatal…
View article: Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates
Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates Open
Perinatal inflammatory stress is associated with early life morbidity and lifelong consequences for pulmonary health. Chorioamnionitis, an inflammatory condition affecting the placenta and fluid surrounding the developing fetus, affects 25…