Christophe Combescure
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View article: Recommended methodologies for clinical investigations of high-risk medical devices—Conclusions from the European Union CORE–MD Project
Recommended methodologies for clinical investigations of high-risk medical devices—Conclusions from the European Union CORE–MD Project Open
The CORE-MD project was funded as a Coordination and Support action from the European UnionHorizon 2020 research and innovation programme, under grant agreement 965246.
View article: Cumulative risk of revision after primary total hip arthroplasty in registries internationally: systematic review and meta-analysis of selected hip stems and cups
Cumulative risk of revision after primary total hip arthroplasty in registries internationally: systematic review and meta-analysis of selected hip stems and cups Open
Purpose The objective was to investigate the consistency in cumulative revision rates (CRRs) for a selection of total hip arthroplasty cups and stems across national/regional hip arthroplasty registries worldwide. Methods Ten cups and ten …
View article: Blood Virome After Allogeneic Hematopoietic Stem Cell Transplantation
Blood Virome After Allogeneic Hematopoietic Stem Cell Transplantation Open
Background Haploidentical allogeneic hematopoietic cell transplant recipients (allo-HCTr) receiving posttransplant cyclophosphamide (haplo-PTCy) are at higher risk for infectious complications, including viral infections. Methods We perfor…
View article: Diagnosis of Peritonsillar Abscess—A Prospective Study Comparing Clinical with CT Findings in 133 Consecutive Patients
Diagnosis of Peritonsillar Abscess—A Prospective Study Comparing Clinical with CT Findings in 133 Consecutive Patients Open
Background: Peritonsillar abscess (PTA) is relatively common but challenging to diagnose clinically. Several clinical signs may be used, with unknown performances. We evaluated and compared the diagnostic performance of individual and comb…
View article: Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study)
Protocol for a multicentric, double-blind, randomised controlled trial of hyperbaric oxygen therapy (HBOT) versus sham for treating vaso-occlusive crisis (VOC) in sickle cell disease (SCD) in patients aged 8 years or older (HBOT-SCD study) Open
Introduction Sickle cell disease (SCD) is one of the most common genetic diseases in the world, annually affecting approximately 310 000 births and causing >100 000 deaths. Vaso-occlusive crisis (VOC) is the most frequent complication of S…
View article: International trends in shoulder replacement: a meta-analysis from 11 public joint registers
International trends in shoulder replacement: a meta-analysis from 11 public joint registers Open
Background and purpose: International variation exists in the types of shoulder replacement used for treatment of specific diseases. Implant choice continues to evolve without high-quality evidence. Our aim was to evaluate trends in incide…
View article: Cumulative risk of revision after primary total hip arthroplasty in registries: Systematic review and meta-analysis of selected hip stems and cups
Cumulative risk of revision after primary total hip arthroplasty in registries: Systematic review and meta-analysis of selected hip stems and cups Open
Purpose The objective was to investigate the consistency in cumulative revision rates for a selection of total hip arthroplasty cups and stems across national/regional hip arthroplasty registries worldwide. Methods Ten cups and 10 stems fr…
View article: Host biomarkers and combinatorial scores for the detection of serious and invasive bacterial infection in pediatric patients with fever without source
Host biomarkers and combinatorial scores for the detection of serious and invasive bacterial infection in pediatric patients with fever without source Open
Background Improved tools are required to detect bacterial infection in children with fever without source (FWS), especially when younger than 3 years old. The aim of the present study was to investigate the diagnostic accuracy of a host s…
View article: Clinical investigations to evaluate high-risk orthopaedic devices: a systematic review of the peer-reviewed medical literature
Clinical investigations to evaluate high-risk orthopaedic devices: a systematic review of the peer-reviewed medical literature Open
Purpose The objective of this systematic review was to give an overview of clinical investigations regarding hip and knee arthroplasty implants published in peer-reviewed scientific medical journals before entry into force of the EU Medica…
View article: PB0011 Evaluation of the Association between Clinical Events and Apixaban/ Rivaroxaban’s Plasma exposure in Patients from the OptimAT Study
PB0011 Evaluation of the Association between Clinical Events and Apixaban/ Rivaroxaban’s Plasma exposure in Patients from the OptimAT Study Open
Aims: To assess the frequency of APS/aPL in patients with AF, and to investigate the treatment effect of DOACs vs VKAs in pivotal randomized trials.Methods: We searched PubMed for studies reporting APS/aPL in patients with AF (last search …
View article: Clinical investigations to evaluate high-risk orthopaedic devices: systematic review of the peer-reviewed medical literature
Clinical investigations to evaluate high-risk orthopaedic devices: systematic review of the peer-reviewed medical literature Open
Purpose The objective of this systematic review was to give an overview of clinical investigations regarding hip and knee arthroplasty implants published in peer-reviewed scientific medical journals before entry into force of the EU Medica…
View article: Management of injuries in Swiss primary care practices: a cross-sectional study within the Sentinella surveillance system
Management of injuries in Swiss primary care practices: a cross-sectional study within the Sentinella surveillance system Open
INTRODUCTION: Injuries are amongst the most frequent causes of morbidity and mortality worldwide. Our aim was to describe the frequency, type of injury and care provided in primary care in Switzerland. METHODS: We used anonymous data from …
View article: Influence of chemotherapy on postural control and quality of life in women with gynaecological cancer: a protocol of a prospective observational study
Influence of chemotherapy on postural control and quality of life in women with gynaecological cancer: a protocol of a prospective observational study Open
Introduction Chemotherapy-induced peripheral neuropathy is a frequent side effect of some chemotherapies that can cause postural control disorders and has a serious impact on quality of life (QoL). An enhanced understanding of postural con…
View article: Harms and benefits of cervical cancer screening among non-attenders in Switzerland: The transition towards HPV-based screening
Harms and benefits of cervical cancer screening among non-attenders in Switzerland: The transition towards HPV-based screening Open
Human papillomavirus (HPV) testing is replacing cytological screening for cervical cancer. Our aim was to assess the expected benefits and harms of different cervical screening strategies. This study is sub-analysis of a previous cost-effe…
View article: A systematic review and meta-analysis of three risk factors for chronic postsurgical pain: age, sex and preoperative pain
A systematic review and meta-analysis of three risk factors for chronic postsurgical pain: age, sex and preoperative pain Open
This systematic review confirms that younger age, female sex, and preoperative pain are associated with higher risk of developing CPSP in any type of elective non-obstetrical surgery. However, effect sizes are small and quality of evidence…
View article: Kinetics of disappearance and appearance of isoagglutinins A and B after ABO-incompatible hematopoietic stem cell transplantation
Kinetics of disappearance and appearance of isoagglutinins A and B after ABO-incompatible hematopoietic stem cell transplantation Open
ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT) can be complicated by poor red cell engraftment and hemolysis, both mediated by isoagglutinins. Anecdotally, isoagglutinins indicates an activation of donor’s immun…
View article: LOw-dose CT Or Lung UltraSonography versus standard of care based-strategies for the diagnosis of pneumonia in the elderly: protocol for a multicentre randomised controlled trial (OCTOPLUS)
LOw-dose CT Or Lung UltraSonography versus standard of care based-strategies for the diagnosis of pneumonia in the elderly: protocol for a multicentre randomised controlled trial (OCTOPLUS) Open
Introduction Pneumonia is a leading cause of mortality and a common indication for antibiotic in elderly patients. However, its diagnosis is often inaccurate. We aim to compare the diagnostic accuracy, the clinical and cost outcomes and th…
View article: Impact of the Genotype and Phenotype of CYP3A and P-gp on the Apixaban and Rivaroxaban Exposure in a Real-World Setting
Impact of the Genotype and Phenotype of CYP3A and P-gp on the Apixaban and Rivaroxaban Exposure in a Real-World Setting Open
Apixaban and rivaroxaban are the two most prescribed direct factor Xa inhibitors. With the increased use of DOACs in real-world settings, safety and efficacy concerns have emerged, particularly regarding their concomitant use with other dr…
View article: Usability Testing and Technology Acceptance of an mHealth App at the Point of Care During Simulated Pediatric In- and Out-of-Hospital Cardiopulmonary Resuscitations: Study Nested Within 2 Multicenter Randomized Controlled Trials
Usability Testing and Technology Acceptance of an mHealth App at the Point of Care During Simulated Pediatric In- and Out-of-Hospital Cardiopulmonary Resuscitations: Study Nested Within 2 Multicenter Randomized Controlled Trials Open
Background Mobile apps are increasingly being used in various domains of medicine. Few are evidence-based, and their benefits can only be achieved if end users intend to adopt and use them. To date, only a small fraction of mobile apps hav…
View article: Predicting recurrence of hepatocellular carcinoma after liver transplantation using a novel model that incorporates tumor and donor‐related factors
Predicting recurrence of hepatocellular carcinoma after liver transplantation using a novel model that incorporates tumor and donor‐related factors Open
Evidence suggests that liver graft quality impacts on posttransplant recurrence of hepatocellular carcinoma (HCC). As of today, selection criteria only use variables related to tumor characteristics. Within the Scientific Registry of Trans…
View article: Effect of a Mobile App on Prehospital Medication Errors During Simulated Pediatric Resuscitation
Effect of a Mobile App on Prehospital Medication Errors During Simulated Pediatric Resuscitation Open
ClinicalTrials.gov Identifier: NCT03921346.
View article: Physician anaesthesia providers in Switzerland today and tomorrow: results of the National Anaesthesia Workforce Study (NAWOS)
Physician anaesthesia providers in Switzerland today and tomorrow: results of the National Anaesthesia Workforce Study (NAWOS) Open
AIMS OF THE STUDY: The Swiss healthcare system is highly ranked, given its unrestricted access to specialised care and short waiting lists for surgery. However, the need for anaesthetic and surgical care is escalating owing to the increasi…
View article: Impact of a Mobile App on Paramedics’ Perceived and Physiologic Stress Response During Simulated Prehospital Pediatric Cardiopulmonary Resuscitation: Study Nested Within a Multicenter Randomized Controlled Trial
Impact of a Mobile App on Paramedics’ Perceived and Physiologic Stress Response During Simulated Prehospital Pediatric Cardiopulmonary Resuscitation: Study Nested Within a Multicenter Randomized Controlled Trial Open
Background Out-of-hospital cardiac arrests (OHCAs) are stressful, high-stake events that are associated with low survival rates. Acute stress experienced in this situation is associated with lower cardiopulmonary resuscitation performance …