Cristina Hernández
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View article: Sex-specific metabolic effects of Treg expansion in db/db mice
Sex-specific metabolic effects of Treg expansion in db/db mice Open
Introduction Type 2 diabetes mellitus (T2D) is characterized by chronic, low-grade inflammation and immune dysregulation, contributing to insulin resistance and metabolic complications. Regulatory T cells (Tregs) are key modulators of immu…
View article: Preoperative test requests for elective surgeries of different complexity: Appropriateness and interhospital variability
Preoperative test requests for elective surgeries of different complexity: Appropriateness and interhospital variability Open
Inappropriateness of preoperative test requests was high according to hospital protocols and especially high according to the NICE guidelines. Appropriateness was determined by patient characteristics, surgical complexity, and institutiona…
View article: Impact of the new EASO obesity definition on the detection of atheromatosis in subjects with low-to-moderate cardiovascular risk
Impact of the new EASO obesity definition on the detection of atheromatosis in subjects with low-to-moderate cardiovascular risk Open
Background Traditional body mass index (BMI) does not adequately reflect adipose tissue distribution and associated cardiovascular (CV) risk. To improve risk stratification, the European Association for the Study of Obesity (EASO) proposes…
View article: Acute Downregulation of Zinc α2-Glycoprotein: Evidence from Human and HepG2 Cell Studies
Acute Downregulation of Zinc α2-Glycoprotein: Evidence from Human and HepG2 Cell Studies Open
Zinc-alpha2-glycoprotein (ZAG) is a soluble glycoprotein primarily produced in adipocytes and the liver, with key roles in lipid metabolism, including lipolysis and the browning of adipose tissue. Despite extensive studies on its role in r…
View article: Randomized, controlled clinical trial to evaluate analog vs. digital full denture retention v1
Randomized, controlled clinical trial to evaluate analog vs. digital full denture retention v1 Open
Introduction: Advances in digital data collection have encouraged the use of CAD/CAM technology in the fabrication of removable complete dentures, although to date there is no fully digital protocol that completely replaces the analog tech…
View article: Bruton tyrosine kinase covalent inhibition shapes the immune microenvironment in chronic lymphocytic leukemia
Bruton tyrosine kinase covalent inhibition shapes the immune microenvironment in chronic lymphocytic leukemia Open
Continuous treatment with ibrutinib not only exerts tumor control but also enhances T cell function in patients with chronic lymphocytic leukemia (CLL). We conducted longitudinal multi-omics analyses in samples from CLL patients receiving …
View article: Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2+/− rat model
Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2+/− rat model Open
Impaired function of the retinal neurovascular unit (NVU) is an early event in diabetic retinopathy (DR). It has been previously shown that topical delivery of the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin can protect against di…
View article: ETNOBOTÁNICA DE ÁRBOLES ÚTILES EN SISTEMAS AGROFORESTALES DE LA SIERRA DE ZONGOLICA, VERACRUZ, MÉXICO
ETNOBOTÁNICA DE ÁRBOLES ÚTILES EN SISTEMAS AGROFORESTALES DE LA SIERRA DE ZONGOLICA, VERACRUZ, MÉXICO Open
Background: traditional ecological knowledge generated by different human groups is manifested in the various forms of appropriation of nature, particularly by intervening in the growth processes of plant species to take advantage of them …
View article: Ocular and Plasma Pharmacokinetics of Sitagliptin Eye Drops: Preclinical Data
Ocular and Plasma Pharmacokinetics of Sitagliptin Eye Drops: Preclinical Data Open
Background/Objectives: Early stages of diabetic retinopathy are currently considered an unmet medical need due to the lack of effective treatments beyond proper monitoring and control of glycemia and blood pressure. Sitagliptin eye drops h…
View article: Are Alexandrium catenella Blooms Spreading Offshore in Southern Chile? An In-Depth Analysis of the First PSP Outbreak in the Oceanic Coast
Are Alexandrium catenella Blooms Spreading Offshore in Southern Chile? An In-Depth Analysis of the First PSP Outbreak in the Oceanic Coast Open
The blooms of Alexandrium catenella, the main producer of paralytic shellfish toxins worldwide, have become the main threat to coastal activities in Southern Chile, such as artisanal fisheries, aquaculture and public health. Here, we explo…
View article: Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment
Cognitive Profile and Cardiovascular Risk Factors in Older Adults with Mild Cognitive Impairment Open
The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was carried out to descri…
View article: Multi-Omics Exploration of Adaptive Mechanism to BTK Inhibition By Ibrutinib in CLL Identified TMBIM6/BI-1 As a Poor Prognosis Variable and Potential Therapeutic Target
Multi-Omics Exploration of Adaptive Mechanism to BTK Inhibition By Ibrutinib in CLL Identified TMBIM6/BI-1 As a Poor Prognosis Variable and Potential Therapeutic Target Open
Introduction: Ibrutinib is currently part of the therapeutic armamentarium employed in patients with CLL. Despite being an active drug, its usage is not devoid of adverse effects and resistances leading to discontinuation. In addition, cur…
View article: Efficacy of Insulin Titration Driven by SMS in Improving Glycemic Control in People with Type 2 Diabetes
Efficacy of Insulin Titration Driven by SMS in Improving Glycemic Control in People with Type 2 Diabetes Open
Aim: To evaluate the efficacy of the self-management of insulin titration based on information received by the Short Message Service (SMS). Methods: A case-control study including 59 subjects in each arm with 16 weeks of follow-up was perf…
View article: <b>Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy</b>
<b>Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy</b> Open
Hemopexin (HPX) is overexpressed in the retina of diabetic patients, and induces the breakdown of the blood-retinal barrier (BRB) in vitro. The present study was aimed at evaluating whether HPX blockade by specific antibodies (aHPX) could …
View article: <b>Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy</b>
<b>Blocking hemopexin with specific antibodies: a new strategy for treating diabetic retinopathy</b> Open
Hemopexin (HPX) is overexpressed in the retina of diabetic patients, and induces the breakdown of the blood-retinal barrier (BRB) in vitro. The present study was aimed at evaluating whether HPX blockade by specific antibodies (aHPX) could …
View article: Impact of Diabetic Foot Multidisciplinary Unit on Incidence of Lower-Extremity Amputations by Diabetic Foot
Impact of Diabetic Foot Multidisciplinary Unit on Incidence of Lower-Extremity Amputations by Diabetic Foot Open
Background: One of the most devastating complications of diabetes is diabetes-related foot disease (DFD), which is a priority for public health systems. The 2016–2020 Catalonia Health Plan aimed to reduce the incidence of total and major l…
View article: Assessment of dyspneic sensation in patients with type 2 diabetes
Assessment of dyspneic sensation in patients with type 2 diabetes Open
Introduction Individuals with type 2 diabetes (T2D) should be considered a susceptible group for pulmonary dysfunction. So, we aimed to evaluate the sensation of breathlessness in this population by administering two well-validated questio…
View article: Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes
Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes Open
ABSTRACT Objective: Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the present study was to evaluate whether this is an important issue in s…
View article: Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes
Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes Open
OBJECTIVE Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the current study is to evaluate whether this is an important issue in subjects with …
View article: Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes
Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes Open
ABSTRACT Objective: Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the present study was to evaluate whether this is an important issue in s…
View article: Untitled Item Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes
Untitled Item Rapid reduction of HbA1c and early worsening of diabetic retinopathy: A real-world population-based study in subjects with type 2 diabetes Open
ABSTRACT Objective: Early worsening of diabetic retinopathy (EWDR) due to the rapid decrease of blood glucose levels is a concern in diabetes treatment. The aim of the present study was to evaluate whether this is an important issue in s…
View article: What else can we do to prevent diabetic retinopathy?
What else can we do to prevent diabetic retinopathy? Open
The classical modifiable factors associated with the onset and progression of diabetic retinopathy are the suboptimal control of blood glucose levels and hypertension, as well as dyslipidaemia. However, there are other less recognised modi…
View article: Deciphering the role of macrophages and T cells in primary central nervous system lymphoma: tumour aggressiveness and response to immunotherapies
Deciphering the role of macrophages and T cells in primary central nervous system lymphoma: tumour aggressiveness and response to immunotherapies Open
Introduction: Primary Central Nervous System Lymphoma (PCNSL) represents 5% of extranodal lymphomas. The brain has low immunosurveillance which contributes to an inefficient immune response against PCNSL cells. Of notice, up to 70% of pati…
View article: Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications
Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications Open
The etiology of diabetic retinopathy (DR) is complex, multifactorial and compromises all the elements of the retinal neurovascular unit (NVU). This diabetic complication has a chronic low-grade inflammatory component involving multiple inf…