Dan Liu
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View article: Nuclear PD-L1 drives IFN-γ-promoted lung metastasis of triple-negative breast cancer via POLR2A-mediated transcriptional activation of LY6E
Nuclear PD-L1 drives IFN-γ-promoted lung metastasis of triple-negative breast cancer via POLR2A-mediated transcriptional activation of LY6E Open
Our findings unveil a novel IFN-γ-nuclear PD-L1/POLR2A-LY6E signaling axis critical for TNBC lung metastasis. This immune-independent mechanism, driven by nuclear PD-L1 transcriptional activity, provides a mechanistic basis for the limited…
View article: Analysis of the population genetic structure and demographic history of Tilia amurensis and Tilia japonica in China using SSR markers
Analysis of the population genetic structure and demographic history of Tilia amurensis and Tilia japonica in China using SSR markers Open
Tilia amurensis , a deciduous broad-leaved tree, is distributed in regions neighboring those of Tilia japonica populations in China; these plants belong to the Malvaceae family. To date, the genetic status and demographic history of T. jap…
View article: Diagnosis and management of cervical pregnancy with placental implantation: a case report and review of the literature
Diagnosis and management of cervical pregnancy with placental implantation: a case report and review of the literature Open
This case underscores the diagnostic and therapeutic complexities associated with cervical pregnancy, especially when patients present with large lesions and atypical symptoms. Serum HCG levels are crucial for effective clinical decision-m…
View article: Assembly and analysis of the complete mitochondrial genome of endangered plant Tilia amurensis Rupr
Assembly and analysis of the complete mitochondrial genome of endangered plant Tilia amurensis Rupr Open
Introduction Tilia amurensis Rupr., a deciduous tree of the genus Tilia in the Malvaceae family, is classified as a second-class key protected wild plant in China. This study aimed to sequence and analyze the complete mitochondrial genome …
View article: Redox–Amino Acid Metabolic Crosstalk in Ovarian Cancer Stem Cells: Integrating Metabolic Reprogramming, Signaling, and the Tumor Microenvironment
Redox–Amino Acid Metabolic Crosstalk in Ovarian Cancer Stem Cells: Integrating Metabolic Reprogramming, Signaling, and the Tumor Microenvironment Open
Ovarian cancer stem cells (OCSCs) possess stemness; differentiation capacity; and tolerance to oxidative, metabolic, and therapeutic stress, driving recurrence and chemoresistance. Emerging evidence highlights a synergistic interplay betwe…
View article: Construction and validation of gene signature for prognosis and drug sensitivity in cholangiocarcinoma based on cellular senescence related genes
Construction and validation of gene signature for prognosis and drug sensitivity in cholangiocarcinoma based on cellular senescence related genes Open
Cholangiocarcinoma is a very deadly epithelial cell cancer with poor clinical outcome. Cellular senescence plays a vital role in the oncogenesis and the aggressiveness of cholangiocarcinoma. Integrative machine learning procedure including…
View article: Physiological Responses to Thermal Stress in the Liver of Gymnocypris eckloni Revealed by Multi-Omics
Physiological Responses to Thermal Stress in the Liver of Gymnocypris eckloni Revealed by Multi-Omics Open
Climate-change-induced thermal stress poses a significant threat to cold-adapted aquatic species, particularly fish endemic to high-altitude ecosystems such as Gymnocypris eckloni, which is native to the Qinghai-Tibetan Plateau. To elucida…
View article: Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study
Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study Open
The combination of ICIs and AAs showed favorable clinical benefits, safety and tolerability in uHCC patients with CP B cirrhosis, with some patients experiencing improvements in Child-Pugh score. More well-designed studies with larger samp…
View article: Shared senescence-associated gene networks in PCOS and T2DM: biomarker identification and functional validation
Shared senescence-associated gene networks in PCOS and T2DM: biomarker identification and functional validation Open
Background Polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) are two prevalent and interrelated disorders that pose an increasingly significant global health burden. Cellular senescence may represent a pivotal process dr…
View article: Robot-assisted autotransplantation of third molars in the maxilla: two case reports
Robot-assisted autotransplantation of third molars in the maxilla: two case reports Open
Autotransplantation of teeth has attracted increasing attention due to its excellent biocompatibility and ability to preserve natural dentition. However, conventional autotransplantation of tooth techniques are highly technique-sensitive a…
View article: Design and Implementation of An Intelligent Robot Control System Based on Java Inheritance and Polymorphism Characteristics
Design and Implementation of An Intelligent Robot Control System Based on Java Inheritance and Polymorphism Characteristics Open
With the rapid development of robotics technology, designing an efficient, flexible, and scalable control system has become the key to improving robot performance. This paper proposes a design and implementation scheme for an intelligent r…
View article: Astragaloside IV Improves Cognitive Impairment by Reducing β-Amyloid and Tau Protein Deposition in Hippocampal Tissue of db/db Mice: A PET/CT Imaging-Based Study
Astragaloside IV Improves Cognitive Impairment by Reducing β-Amyloid and Tau Protein Deposition in Hippocampal Tissue of db/db Mice: A PET/CT Imaging-Based Study Open
This study found that AS-IV improved cognitive function in diabetic db/db mice by reducing the buildup of Aβ and tau proteins in the hippocampus via the TNF-α-activated EGFR/NF-κB pathway.
View article: A Hospital Infection Management Department-Led Intervention to Improve the Pathogen Submission Rate Before Antimicrobial Therapy Using a FOCUS-PDCA Model
A Hospital Infection Management Department-Led Intervention to Improve the Pathogen Submission Rate Before Antimicrobial Therapy Using a FOCUS-PDCA Model Open
The FOCUS-PDCA model effectively improved pathogen submission rates and specimen quality, reduced the detection rate of MDRO, and promoted rational antimicrobial use. This approach provides valuable experience for other clinical institutio…
View article: Multi-dimensional Multi-omics Integrative Study to Identify Target Genes for Ischemic Stroke and Related Chronic Pain
Multi-dimensional Multi-omics Integrative Study to Identify Target Genes for Ischemic Stroke and Related Chronic Pain Open
Chronic pain is the most common complications and after-effects for ischemic stroke. Through exploring immune related cell death target genes of ischemic stroke is essential for understanding ischemic stroke and chronic pain complications.…
View article: Deciphering the significant impact of natural glycosylation on human insulin
Deciphering the significant impact of natural glycosylation on human insulin Open
In the century-long evolution of insulin pharmaceuticals, each transformative advancement in this drug class has been closely tied to the ability to obtain new insulin isoforms for research. Despite this, the recently discovered naturally …
View article: The role of mitochondria-related genes and immune infiltration in carotid atherosclerosis: identification of hub targets through bioinformatics and machine learning approaches
The role of mitochondria-related genes and immune infiltration in carotid atherosclerosis: identification of hub targets through bioinformatics and machine learning approaches Open
Objective Atherosclerosis (AS) is the underlying pathology of atherosclerotic cardiovascular disease and a major cause of cardiovascular-related mortality. Chronic inflammation and mitochondrial dysfunction, triggered by the infiltration o…
View article: Relationships between different components of intolerance of uncertainty and symptoms of obsessive–compulsive disorder: a network analysis
Relationships between different components of intolerance of uncertainty and symptoms of obsessive–compulsive disorder: a network analysis Open
Background Previous studies have shown that intolerance of uncertainty (IU) and obsessive–compulsive disorder (OCD) are closely interrelated. This reliance on scale totals to measure symptom severity obscures the distinctions and connectio…
View article: Beyond the Surface: Investigating the Potential Mechanisms of Non‐Motor Symptoms in Myasthenia Gravis
Beyond the Surface: Investigating the Potential Mechanisms of Non‐Motor Symptoms in Myasthenia Gravis Open
Background Myasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction (NMJ), driven by T cells, mediated by B cells, and dependent on autoantibodies. In addition to the typical motor symptoms of fluctuating weakn…
View article: Prognostic value of longitudinal strain relative apical sparing in severe aortic stenosis patients undergoing TAVR
Prognostic value of longitudinal strain relative apical sparing in severe aortic stenosis patients undergoing TAVR Open
Aims This study evaluated the prognostic value of the relative apical sparing pattern (RASP) of longitudinal strain (LS) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) and investigated…
View article: Dynamic balance of the lung microbiome in health and respiratory diseases
Dynamic balance of the lung microbiome in health and respiratory diseases Open
Recent studies have challenged the once prevalent notion that the human lungs are sterile, instead unveiling a dynamic microbial environment that interacts intricately with both the host and external factors. This review describes the dist…
View article: Efficacy analysis of comprehensive rehabilitation therapy based on the Gesell developmental schedules among infants with global developmental delay of different ages: a retrospective study
Efficacy analysis of comprehensive rehabilitation therapy based on the Gesell developmental schedules among infants with global developmental delay of different ages: a retrospective study Open
Objective This study aimed to analyze differences in efficacy using the Gesell Developmental Schedules (GDS) among infant patients with global developmental delay (GDD), thereby providing an objective basis for early intervention. Methods …
View article: Automated sparse feature selection in high-dimensional proteomics data via 1-bit compressed sensing and K-Medoids clustering
Automated sparse feature selection in high-dimensional proteomics data via 1-bit compressed sensing and K-Medoids clustering Open
Background High-dimensional proteomics data present significant challenges in biomarker discovery due to technical noise, feature redundancy, and multicollinearity. Current feature selection methods, including filter, wrapper, and embedded…
View article: Assembly and comparative analysis of the complete mitochondrial genome of Cardiocrinum giganteum: a primitive Liliaceae group with significant scientific research value
Assembly and comparative analysis of the complete mitochondrial genome of Cardiocrinum giganteum: a primitive Liliaceae group with significant scientific research value Open
BACKGROUND : Cardiocrinum giganteum, belonging to genus Cardiocrinum of family Liliaceae, is a genus endemic to East Asia and is considered one of the more primitive groups within the Liliaceae family. C. giganteum is the largest one among…
View article: Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study
Comparative efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic agents for unresectable hepatocellular carcinoma in patients with Child-Pugh A versus B cirrhosis: a single-center, retrospective study Open
Background Immune checkpoint inhibitors (ICIs) combined with antiangiogenic agents (AAs) have been recommended as the first-line systemic treatment for unresectable hepatocellular carcinoma (uHCC). However, most Phase III clinical trials h…