D’Angelo Carlo Magliano
YOU?
Author Swipe
View article: Unstressing the Reticulum: Nutritional Strategies for Modulating Endoplasmic Reticulum Stress in Obesity
Unstressing the Reticulum: Nutritional Strategies for Modulating Endoplasmic Reticulum Stress in Obesity Open
The progression of obesity involves several molecular mechanisms that are closely associated with the pathophysiological response of the disease. Endoplasmic reticulum (ER) stress is one such factor. Lipotoxicity disrupts endoplasmic retic…
View article: Experimental Model Exposed to Bisphenol and Submitted to a High-Fat Diet and Related Morphologic Testicular Parameters Alterations Analysis
Experimental Model Exposed to Bisphenol and Submitted to a High-Fat Diet and Related Morphologic Testicular Parameters Alterations Analysis Open
Animals exposed to bisphenol S and/or high-fat diet-induced obesity presented important structural alterations in testicular morphology.
View article: Periodontal pathogen <i>Aggregatibacter actinomycetemcomitans</i><scp>JP2</scp> correlates with colonic leukocytes decrease and gut microbiome imbalance in mice
Periodontal pathogen <i>Aggregatibacter actinomycetemcomitans</i><span>JP2</span> correlates with colonic leukocytes decrease and gut microbiome imbalance in mice Open
Aim Evidence suggests that translocation of oral pathogens through the oral–gut axis may induce intestinal dysbiosis. This study aimed to evaluate the impact of a highly leukotoxic Aggregatibacter actinomycetemcomitans ( Aa ) strain on the…
View article: Obesity‐induced skeletal muscle remodeling: A comparative analysis of exercise training and ACE‐inhibitory drug in male mice
Obesity‐induced skeletal muscle remodeling: A comparative analysis of exercise training and ACE‐inhibitory drug in male mice Open
Obesity over‐activates the classical arm of the renin‐angiotensin system (RAS), impairing skeletal muscle remodeling. We aimed to compare the effect of exercise training and enalapril, an angiotensin‐converting enzyme inhibitor, on RAS mod…
View article: Pyriproxyfen, villain or good guy? A brief review
Pyriproxyfen, villain or good guy? A brief review Open
Pyriproxyfen (PPF) acts as a juvenile growth regulator, interfering with normal metamorphosis and blocking the development of insects into adulthood. Although the World Health Organization (WHO) considers the use of PPF at a concentration …
View article: Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic–Pituitary–Thyroid Axis
Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic–Pituitary–Thyroid Axis Open
Parabens are classified as endocrine-disrupting chemicals (EDCs) capable of interfering with the normal functioning of the thyroid, affecting the proper regulation of the biosynthesis of thyroid hormones (THs), which is controlled by the h…
View article: Environmental Endocrinology: Parabens Hazardous Effects on HPT Axis
Environmental Endocrinology: Parabens Hazardous Effects on HPT Axis Open
Parabens are classified as endocrine disrupting compounds (EDCs), capable of interfering with the normal functioning of the thyroid, affecting the proper regulation of the biosynthesis of thyroid hormones (TH) which is controlled by hypoth…
View article: Use of Hemostatic Compression in the Making of the Nx 5/6 Experimental Model in Wistar Rats
Use of Hemostatic Compression in the Making of the Nx 5/6 Experimental Model in Wistar Rats Open
Objectives: To enhance the technique for the creation of the experimental model for chronic kidney disease with 5/6 nephrectomy and to establish parameters for the postoperative evaluation of animals undergoing the surgical procedure.Metho…
View article: Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats Open
Short-term exercise, continuous or HIIT, restored HFD-induced muscle atrophy and increased mTOR expression, but only HIIT maintained myocardial contractility following IRI in obese animals.
View article: Nutritional strategies to modulate inflammation pathways via regulation of peroxisome proliferator-activated receptor β/δ
Nutritional strategies to modulate inflammation pathways via regulation of peroxisome proliferator-activated receptor β/δ Open
The peroxisome proliferator-activated receptor (PPAR) β/δ has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPARβ/δ forms…
View article: Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins
Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins Open
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole a…
View article: GW501516 Ameliorates A Fructose-Induced Inflammation Independent of AT1r Downregulation in Kidney
GW501516 Ameliorates A Fructose-Induced Inflammation Independent of AT1r Downregulation in Kidney Open
AT1r high activation is linked to low-grade inflammation and oxidative stress, which yield impaired renal function. This study aimed to verify if GW501516 could improve damage in the kidney of mice with high activation of AT1r. Mice were f…
View article: GW501516, a PPAR-BETA/DELTA agonist, improves inflammatory pathways in the kidney of high-fructose fed mice
GW501516, a PPAR-BETA/DELTA agonist, improves inflammatory pathways in the kidney of high-fructose fed mice Open
Materials and methods To induce high activation of this receptor, mice were fed a high-fructose diet for eight weeks. The control group only received standard-chow (SC). After, the animals were randomly divided into four groups and the adm…