Christopher G. Davey
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View article: Functional Connectivity of the Subgenual Anterior Cingulate Cortex Predicts Emerging Depressive Symptoms Between Mid and Late Adolescence
Functional Connectivity of the Subgenual Anterior Cingulate Cortex Predicts Emerging Depressive Symptoms Between Mid and Late Adolescence Open
Functional Connectivity of the Subgenual Anterior Cingulate Cortex Predicts Emerging Depressive Symptoms Between Mid and Late Adolescence
View article: Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group Open
The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology …
View article: Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model
Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model Open
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, l…
View article: Disorder at the Synapse: How the Active Inference Framework Unifies Competing Perspectives on Depression
Disorder at the Synapse: How the Active Inference Framework Unifies Competing Perspectives on Depression Open
Depression is one of the most disabling of all disorders across the community, yet many aspects of the disorder remain contentious. Psychosocial and biological perspectives are often placed in opposition to one another, which in part refle…
View article: Addressing the unmet needs of bipolar disorder in Australia and beyond
Addressing the unmet needs of bipolar disorder in Australia and beyond Open
People impacted by bipolar disorder are confronted by many unmet needs that contribute to the overall burden associated with the disorder. We do not have a good understanding of the underlying pathology of bipolar disorder, so we do not ha…
View article: Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders
Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders Open
Dysfunctional processing of negative emotional events is a key transdiagnostic feature of mood and anxiety disorders. This dysfunction is often associated with aberrant functioning of fronto-insular/cingulate regions involved in salience p…
View article: The elusive neural signature of emotion regulation capabilities: evidence from a large-scale consortium
The elusive neural signature of emotion regulation capabilities: evidence from a large-scale consortium Open
Cognitive reappraisal is a fundamental emotion regulation strategy for mental and physical well-being, but how its neural mechanisms relate to individual differences remains poorly understood. In a consortium effort analyzing 40 fMRI datas…
View article: Shared and Distinct Alterations in Brain Structure of Youth With Internalizing or Externalizing Disorders: Findings From the ENIGMA Antisocial Behavior, ADHD, Major Depressive Disorder, and Anxiety Working Groups
Shared and Distinct Alterations in Brain Structure of Youth With Internalizing or Externalizing Disorders: Findings From the ENIGMA Antisocial Behavior, ADHD, Major Depressive Disorder, and Anxiety Working Groups Open
View article: 621. MENTAL HEALTH AUSTRALIA GENERAL CLINICAL TRIAL NETWORK (MAGNET) – CONNECTING KNOWLEDGE FOR BETTER MENTAL HEALTH OUTCOMES
621. MENTAL HEALTH AUSTRALIA GENERAL CLINICAL TRIAL NETWORK (MAGNET) – CONNECTING KNOWLEDGE FOR BETTER MENTAL HEALTH OUTCOMES Open
Background Mental Health Australia General Clinical Trials Network (MAGNET) is the first network in Australia dedicated to clinical trials in adult mental health, aiming to advance prevention, diagnosis, treatment, and recovery. Funded thr…
View article: Are neuroanatomical phenotypes for psychiatric disorders robust? An assessment of the reproducibility of grey matter differences in mental illness
Are neuroanatomical phenotypes for psychiatric disorders robust? An assessment of the reproducibility of grey matter differences in mental illness Open
Background Despite thousands of magnetic resonance imaging (MRI) studies reporting grey matter alterations in psychiatric disorders, the field has failed to converge on robust neuroanatomical phenotypes for any specific diagnosis. Here, we…
View article: Predicting the First Onset of Suicidal Thoughts and Behaviors in Adolescents Using Multimodal Risk Factors: A 4-Year Longitudinal Study
Predicting the First Onset of Suicidal Thoughts and Behaviors in Adolescents Using Multimodal Risk Factors: A 4-Year Longitudinal Study Open
We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnai…
View article: Bipolar Early Intervention Using New Digital Technologies (BLEND): A Pilot Randomised Controlled Trial of a Novel Blended‐Digital Early Intervention Model of Care for Youth With Bipolar Disorder I or II
Bipolar Early Intervention Using New Digital Technologies (BLEND): A Pilot Randomised Controlled Trial of a Novel Blended‐Digital Early Intervention Model of Care for Youth With Bipolar Disorder I or II Open
Background Despite evidence for early interventions for bipolar disorder (BD), there are relatively few accessible treatment models. We developed a digitally augmented model of care termed BLEND (BipoLar early interventions using New Digit…
View article: The body intervenes: How active inference explains depression’s clinical presentation
The body intervenes: How active inference explains depression’s clinical presentation Open
The low mood that characterises depression is accompanied by changes in bodily processes, manifested in symptoms such as insomnia, reduced appetite and fatigue. The active inference framework provides an explanation as to how mood-related …
View article: Habenula contributions to negative self-cognitions
Habenula contributions to negative self-cognitions Open
View article: Accurate correction with a novel patient-specific instrument for medial opening wedge high tibial osteotomy
Accurate correction with a novel patient-specific instrument for medial opening wedge high tibial osteotomy Open
Level IV, Retrospective Case Series.
View article: Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study
Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study Open
Importance Major depressive disorder (MDD) is highly heterogeneous, with marked individual differences in clinical presentation and neurobiology, which may obscure identification of structural brain abnormalities in MDD. To explore this, w…
View article: Systematic Review and Meta-Analysis: Predictors of Relapsing, Recurrent, and Chronic Depression in Young People
Systematic Review and Meta-Analysis: Predictors of Relapsing, Recurrent, and Chronic Depression in Young People Open
Prognostic factors for relapsing, recurrent or chronic depression in youth: a systematic review with meta-analysis; https://www.crd.york.ac.uk/PROSPERO/view/CRD42023458646.
View article: 14 Accuracy of school-led vision checks in primary and secondary school students within the UK
14 Accuracy of school-led vision checks in primary and secondary school students within the UK Open
View article: Neural Correlates and Sex‐Specific Effects of Affectively Driven Processes Underlying Decision‐Making in Adult ADHD
Neural Correlates and Sex‐Specific Effects of Affectively Driven Processes Underlying Decision‐Making in Adult ADHD Open
Aims Adults with attention‐deficit/hyperactivity disorder (ADHD) often exhibit heightened risk‐taking behavior due to disadvantageous decision‐making. This study investigates the influence of preceding unconscious and affectively driven pr…
View article: Advancing the quality and safety of behavioural interventions in mental health research: A how-to guide from the MAGNET Clinical Trial Network
Advancing the quality and safety of behavioural interventions in mental health research: A how-to guide from the MAGNET Clinical Trial Network Open
This is the first in a series of Position Papers from the Mental Health Australia General Clinical Trials Network (MAGNET) intended to promote the standard of mental health research in Australia. This paper focuses on improving the quality…
View article: Safety and efficacy of methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in post-traumatic stress disorder: An overview of systematic reviews and meta-analyses
Safety and efficacy of methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in post-traumatic stress disorder: An overview of systematic reviews and meta-analyses Open
Objective: To critically evaluate published and unpublished systematic reviews and meta-analyses on the safety and efficacy of methylenedioxymethamphetamine-assisted psychotherapy for post-traumatic stress disorder. Methods: Six bibliometr…
View article: Towards an expanded neurocognitive account of ketamine’s rapid antidepressant effects
Towards an expanded neurocognitive account of ketamine’s rapid antidepressant effects Open
Ketamine is an N-methyl-D-aspartate receptor antagonist that has shown effectiveness as a rapidly acting treatment for depression. Although advances have been made in understanding ketamine’s antidepressant pharmacological and molecular me…
View article: Habenula neural circuitry drives negative self-cognitions
Habenula neural circuitry drives negative self-cognitions Open
Self-related cognitions are integral to personal identity and psychological wellbeing. Persistent engagement with negative self-cognitions can precipitate mental ill health; whereas the ability to restructure them is protective. Here, we l…
View article: Adverse childhood experiences and their differential relationships with transdiagnostic mental health outcomes in young adults
Adverse childhood experiences and their differential relationships with transdiagnostic mental health outcomes in young adults Open
Adverse childhood experiences (ACEs) are associated with poor mental health outcomes, which are increasingly conceptualized from a transdiagnostic perspective. We examined the impact of ACEs on transdiagnostic mental health outcomes in you…
View article: Graded changes in local functional connectivity of the cerebral cortex in young people with depression
Graded changes in local functional connectivity of the cerebral cortex in young people with depression Open
Background Major depressive disorder (MDD) is marked by significant changes to the local synchrony of spontaneous neural activity across various brain regions. However, many methods for assessing this local connectivity use fixed or arbitr…
View article: Cognitive-Behavioural Therapy Skill Acquisition: Impact on Trajectories in Depression Symptoms and Suicidal Ideation: Secondary Analysis of a Randomised Controlled Trial of Cognitive Behavioural Therapy Plus Fluoxetine in Young People Experiencing Depression
Cognitive-Behavioural Therapy Skill Acquisition: Impact on Trajectories in Depression Symptoms and Suicidal Ideation: Secondary Analysis of a Randomised Controlled Trial of Cognitive Behavioural Therapy Plus Fluoxetine in Young People Experiencing Depression Open
View article: Predicting Antidepressant Treatment Response From Cortical Structure on <scp>MRI</scp>: A Mega‐Analysis From the <scp>ENIGMA</scp>‐<scp>MDD</scp> Working Group
Predicting Antidepressant Treatment Response From Cortical Structure on <span>MRI</span>: A Mega‐Analysis From the <span>ENIGMA</span>‐<span>MDD</span> Working Group Open
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial‐and‐error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning‐based meth…
View article: Psychometric properties of the Bipolar Spectrum Diagnostic Scale in depressed youth
Psychometric properties of the Bipolar Spectrum Diagnostic Scale in depressed youth Open
At recommended thresholds, BSDS has high false positive rates for detecting current BD in youth with moderate to severe depression, especially with mental state or personality disorder comorbidities.
View article: Altered basal forebrain regulation of intrinsic brain networks in depressive and anxiety disorders
Altered basal forebrain regulation of intrinsic brain networks in depressive and anxiety disorders Open
Depressive and anxiety disorders are characterized by altered connectivity within and between the default mode (DMN) and salience networks. Basal forebrain subdivisions, critical for regulating network activity, remain understudied across …
View article: Youth codesign of a mobile phone app to facilitate self-monitoring and management of mood symptoms in young people with major depression, suicidal ideation, and self-harm
Youth codesign of a mobile phone app to facilitate self-monitoring and management of mood symptoms in young people with major depression, suicidal ideation, and self-harm Open
Background: Effective treatment of depression in young people is critical, given its prevalence, impacts, and link to suicide. Clinical practice guidelines point to the need for regular monitoring of depression symptom severity and the eme…