Carmela De Santo
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View article: Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models
Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models Open
View article: Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections
Not only COVID-19: a systematic review of anti-COVID-19 measures and their effect on healthcare-associated infections Open
Anti-COVID-19 measures have shown selective efficacy in preventing HAIs. The study emphasizes the need for context-specific strategies and increased focus on regions with limited resources. Continued research is essential to refine infecti…
View article: PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults
PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults Open
Background The survival for many children with relapsed/refractory cancers remains poor despite advances in therapies. Arginine metabolism plays a key role in the pathophysiology of a number of pediatric cancers. We report the first in chi…
View article: 712 IMPORT-201 (IMP-MEL): a phase 1 first-in-human dose finding/randomized phase 2 study of a novel iNKT agonist (PORT-2) and pembrolizumab for advanced melanoma and non-small cell lung cancer (NSCLC)
712 IMPORT-201 (IMP-MEL): a phase 1 first-in-human dose finding/randomized phase 2 study of a novel iNKT agonist (PORT-2) and pembrolizumab for advanced melanoma and non-small cell lung cancer (NSCLC) Open
Background Invariant natural killer T-cells (iNKTs) share features of NK-like cells and T-cells, playing a role in both innate and adaptive immune responses. The importance of this relatively rare lymphocyte subset has generated interest d…
View article: Costs and control strategies of healthcare-associated infections in an Italian university hospital
Costs and control strategies of healthcare-associated infections in an Italian university hospital Open
Backgrounds Healthcare-associated infections (HAIs) increase morbidity, mortality, and costs, necessitating effective prevention strategies. This study estimates the additional costs of HAIs in a university hospital in Rome, Italy Policlin…
View article: Supplementary Figure 3 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 3 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 3 Neuroblastoma conditioning upregulates IL-1ï�¢ï€ and TNF-ï�¡ï€ expression in macrophages
View article: Supplementary Materials and Methods from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Materials and Methods from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Materials and Methods CLEAN version
View article: Supplementary Figure 4 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 4 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 4 Macrophage infiltration and downstream effects on neuroblastoma tumours
View article: Supplementary figure 1 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary figure 1 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Arginase activity does not drive immunosuppressive granulocyte function
View article: Supplementary Figure 2 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 2 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 2 Cytokine profile of tumour induced macrophages or granulocytes
View article: Supplementary Figure 5 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 5 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 5 : IL-1ï�¢ï€ and TNF-ï�¡ï€ drive neuroblastoma cell proliferation
View article: Supplementary figure 2 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary figure 2 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Mesothelioma granulocytes suppress T cell activation
View article: Data from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Data from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Purpose: The cross-talk between tumor cells, myeloid cells, and T cells can play a critical role in tumor pathogenesis and response to immunotherapies. Although the etiology of mesothelioma is well understood, the impact of mesothel…
View article: Supplementary Figs and Tables from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary Figs and Tables from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Supplementary Figs and Tables
View article: Supplementary figure 3 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary figure 3 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Mesothelioma upregulates ROS production by granulocytes
View article: Supplementary Figure 4 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 4 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 4 Macrophage infiltration and downstream effects on neuroblastoma tumours
View article: Data from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Data from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeti…
View article: Supplementary Figure 2 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 2 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 2 Cytokine profile of tumour induced macrophages or granulocytes
View article: Supplementary Figs and Tables from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary Figs and Tables from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Supplementary Figs and Tables
View article: Supplementary Figure 3 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 3 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 3 Neuroblastoma conditioning upregulates IL-1ï�¢ï€ and TNF-ï�¡ï€ expression in macrophages
View article: Supplementary Figure 5 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 5 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 5 : IL-1ï�¢ï€ and TNF-ï�¡ï€ drive neuroblastoma cell proliferation
View article: Supplementary Figure 1 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure 1 from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure 1: M1-Macrophage infiltrate neuroblastoma
View article: Supplementary Figure Legends and Table from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure Legends and Table from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure Legends and Tables
View article: Supplementary figure 4 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary figure 4 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
GM-CSF drives ROS release in granulocytes
View article: Data from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Data from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Purpose: The cross-talk between tumor cells, myeloid cells, and T cells can play a critical role in tumor pathogenesis and response to immunotherapies. Although the etiology of mesothelioma is well understood, the impact of mesothel…
View article: Supplementary Figure Legends and Table from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Figure Legends and Table from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Figure Legends and Tables
View article: Supplementary figure 4 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary figure 4 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
GM-CSF drives ROS release in granulocytes
View article: Data from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Data from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeti…
View article: Supplementary Materials and Methods from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Supplementary Materials and Methods from Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma Open
Supplementary Materials and Methods CLEAN version
View article: Supplementary figure 2 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
Supplementary figure 2 from Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients Open
Mesothelioma granulocytes suppress T cell activation