A. Courtney DeVries
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View article: Circadian influences on central nervous system barriers and the glymphatic system
Circadian influences on central nervous system barriers and the glymphatic system Open
The central nervous system (CNS), comprising the brain and spinal cord, is fortified by complex barriers that protect the underlying organs and maintain homeostasis. The importance of proper fortification and homeostatic regulation provide…
View article: Challenging the norm – cull rates and farm economics
Challenging the norm – cull rates and farm economics Open
Culling has often been seen as removal of cows from the herd that were either too broken or did not pay for their feed cost anymore. This norm on cull rates may be challenged in several different ways. First, cow replacement rates are prim…
View article: Window into the Brain: In Vivo Multiphoton Imaging
Window into the Brain: In Vivo Multiphoton Imaging Open
Decoding the principles underlying neuronal information processing necessitates the emergence of techniques and methodologies to monitor multiscale brain networks in behaving animals over long periods of time. Novel advances in biophotonic…
View article: Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy
Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy Open
View article: Prediction of daily new COVID-19 cases ‐ Difficulties and possible solutions
Prediction of daily new COVID-19 cases ‐ Difficulties and possible solutions Open
Epidemiological compartmental models, such as SEIR (Susceptible, Exposed, Infectious, and Recovered) models, have been generally used in analyzing epidemiological data and forecasting the trajectory of transmission of infectious diseases s…
View article: Researchers need to better address time-of-day as a critical biological variable
Researchers need to better address time-of-day as a critical biological variable Open
Large volumes of liquid water transiently existed on the surface of Mars more than 3 billion years ago. Much of this water is hypothesized to have been sequestered in the subsurface or lost to space. We use rock physics models and Bayesian…
View article: Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice
Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice Open
View article: Chronic phase advances reduces recognition memory and increases vascular cognitive dementia-like impairments in aged mice
Chronic phase advances reduces recognition memory and increases vascular cognitive dementia-like impairments in aged mice Open
Disrupted or atypical light–dark cycles disrupts synchronization of endogenous circadian clocks to the external environment; extensive circadian rhythm desynchrony promotes adverse health outcomes. Previous studies suggest that disrupted c…
View article: Time of day bias for biological sampling in studies of mammary cancer
Time of day bias for biological sampling in studies of mammary cancer Open
Despite its demonstrated biological significance, time of day is a broadly overlooked biological variable in preclinical and clinical studies. How time of day affects the influence of peripheral tumors on central (brain) function remains u…
View article: Social enrichment alters the response of brain leukocytes to chemotherapy and tumor development in aged mice
Social enrichment alters the response of brain leukocytes to chemotherapy and tumor development in aged mice Open
View article: Chronotherapeutics for Solid Tumors
Chronotherapeutics for Solid Tumors Open
Circadian rhythms are internal manifestations of the 24-h solar day that allow for synchronization of biological and behavioral processes to the external solar day. This precise regulation of physiology and behavior improves adaptive funct…
View article: Astrocytic deletion of protein kinase R‐like <scp>ER</scp> kinase ( <scp>PERK</scp> ) does not affect learning and memory in aged mice but worsens outcome from experimental stroke
Astrocytic deletion of protein kinase R‐like <span>ER</span> kinase ( <span>PERK</span> ) does not affect learning and memory in aged mice but worsens outcome from experimental stroke Open
Aging is associated with cognitive decline and is the main risk factor for a myriad of conditions including neurodegeneration and stroke. Concomitant with aging is the progressive accumulation of misfolded proteins and loss of proteostasis…
View article: Acute exposure to artificial light at night alters hippocampal vascular structure in mice
Acute exposure to artificial light at night alters hippocampal vascular structure in mice Open
The structure and function of the cardiovascular system are modulated across the day by circadian rhythms, making this system susceptible to circadian rhythm disruption. Recent evidence demonstrated that short-term exposure to a pervasive …
View article: The role of daylight exposure on body mass in male mice
The role of daylight exposure on body mass in male mice Open
View article: Supplementary Figure 4 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 4 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Neither norepinephrine nor recombinant CCL2 have proliferative effects on B16F10 cells.
View article: Supplementary Table from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Table from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Supplementary Table for qPCR sequences
View article: Supplementary Figure 1 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 1 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Stress confers survival in a murine model of melanoma.
View article: Supplementary Figure 5 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 5 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Restraint stress increases tumor CD3+/CD4+ T cell infiltration
View article: Supplementary Figure 2 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 2 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Stress correlates with reduced tumor size and burden, VEGF and CCL2 levels, and infiltrating macrophages compared to unstressed mice.
View article: Supplementary Figure 5 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 5 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Restraint stress increases tumor CD3+/CD4+ T cell infiltration
View article: Data from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Data from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Psychological stressors have been implicated in the progression of various tumor types. We investigated a role for stress in tumor immune cell chemotaxis in the B16F10 mouse model of malignant melanoma. We exposed female mice to 6-hour per…
View article: Data from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Data from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Psychological stressors have been implicated in the progression of various tumor types. We investigated a role for stress in tumor immune cell chemotaxis in the B16F10 mouse model of malignant melanoma. We exposed female mice to 6-hour per…
View article: Supplementary Figure 1 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 1 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Stress confers survival in a murine model of melanoma.
View article: Supplementary Figure 3 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 3 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Neither norepinephrine nor recombinant CCL2 have toxic effects on B16F10 cells.
View article: Supplementary Figure 4 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 4 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Neither norepinephrine nor recombinant CCL2 have proliferative effects on B16F10 cells.
View article: Supplementary Figure 2 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 2 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Stress correlates with reduced tumor size and burden, VEGF and CCL2 levels, and infiltrating macrophages compared to unstressed mice.
View article: Supplementary Table from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Table from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Supplementary Table for qPCR sequences
View article: Supplementary Figure 3 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma
Supplementary Figure 3 from Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma Open
Neither norepinephrine nor recombinant CCL2 have toxic effects on B16F10 cells.
View article: Chronic exposure to dim light at night disrupts cell-mediated immune response and decreases longevity in aged female mice
Chronic exposure to dim light at night disrupts cell-mediated immune response and decreases longevity in aged female mice Open
Circadian rhythms are endogenous biological cycles that regulate physiology and behavior for optimal adaptive function and survival; they are synchronized to precisely 24 hours by daily light exposure. Disruption of the daily light-dark (L…
View article: Aromatase Inhibitor Induced Musculoskeletal Inflammation is Observed Independent of Oophorectomy in a Novel Mouse Model
Aromatase Inhibitor Induced Musculoskeletal Inflammation is Observed Independent of Oophorectomy in a Novel Mouse Model Open
Background Aromatase Inhibitors (AIs) block physiological estrogen production in peripheral tissues and are used clinically to reduce disease recurrences and improve overall survival rates in hormone receptor-positive breast cancer patient…