Amy C. Durham
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Preliminary evaluation of the safety and feasibility of toll-like receptor ligand CB101 combined with hypofractionated radiation therapy in canine head and neck cancer: a pilot study Open
Radiation therapy (RT) is a common treatment modality for dogs with locally advanced head and neck tumors. Most dogs experience a clinical benefit secondary to RT, however, long term remissions are rare. This study evaluates the feasibilit…
View article: Clinical and histological characterization of 19 chondro-osseous respiratory epithelial adenomatoid hamartomas and 2 respiratory epithelial adenomatoid hamartomas in dogs
Clinical and histological characterization of 19 chondro-osseous respiratory epithelial adenomatoid hamartomas and 2 respiratory epithelial adenomatoid hamartomas in dogs Open
Nasal biopsies from 21 dogs diagnosed with chondro-osseous respiratory epithelial adenomatoid hamartomas or respiratory epithelial adenomatoid hamartomas were reviewed. Associated lesions included angiomatous tissue (4/21), seromucinous gl…
Canine laryngotracheal plasma cell tumors: Ten cases and literature review Open
Canine extramedullary plasma cell tumors (EMPs) most commonly arise in the skin, oral cavity, rectum, and colon. This retrospective study describes the histopathological and immunohistochemical characteristics and associated clinical signs…
View article: A combination of pre‐ and intraoperative techniques identifies sentinel lymph nodes in dogs with thyroid carcinoma: A pilot study
A combination of pre‐ and intraoperative techniques identifies sentinel lymph nodes in dogs with thyroid carcinoma: A pilot study Open
Objective The aim of this study was to develop and describe pre‐ and intra‐operative sentinel lymph node (SLN) mapping techniques in dogs with thyroid carcinoma. Study design A prospective, pilot clinical trial was performed. Animals Six c…
Hyalinizing pancreatic adenocarcinoma in a cat Open
Case summary A 6-year-old female spayed domestic shorthair cat was presented for abdominal distension and weight loss. Abdominal radiographs and ultrasound revealed two cranial abdominal masses and another mass adjacent to the jejunum. Cyt…
Clinical descriptive and long‐term outcome of melanocytic uveal lesions in young dogs: 40 cases (45 eyes) including 13 cases of sector iridectomy Open
Purpose To describe the clinical features surgical technique, early and long‐term outcome with or without surgery, and histopathological findings of melanocytic anterior uveal lesions in young dogs. Methods Medical records of dogs at a gui…
View article: Supplementary Figure Legend from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Supplementary Figure Legend from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
PDF file - 135K
View article: Supplementary Figures 1 - 9 from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Supplementary Figures 1 - 9 from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
PDF file - 1196K, Supplementary Figure 1. Phenotypic analysis of FAP+ stromal cells in untreated TC1 flank tumors in C57BL/6 mice. Supplementary Figure 2. Depletion of FAP+ cells. Supplementary Figure 3. Persistence and antitumor activitie…
View article: Supplementary Figure Legend from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Supplementary Figure Legend from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
PDF file - 135K
Supplementary Figures S1 - S8 from <i>Hif1a</i> Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia Open
Supplementary Figure S1. HIF1α is dispensable for pancreas development. Supplementary Figure S2. Additional characterization of KrasG12D;Hif1αKO animals. Supplementary Figure S3. Disease spectrum of KrasG12D and KrasG12D;Hif1αKO mice. Supp…
View article: Supplementary Methods from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Supplementary Methods from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
PDF file - 135K
Data from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal cells using CAR T cells may offer several advantages. We develo…
Supplementary Figures S1 - S8 from <i>Hif1a</i> Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia Open
Supplementary Figure S1. HIF1α is dispensable for pancreas development. Supplementary Figure S2. Additional characterization of KrasG12D;Hif1αKO animals. Supplementary Figure S3. Disease spectrum of KrasG12D and KrasG12D;Hif1αKO mice. Supp…
Data from <i>Hif1a</i> Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia Open
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths worldwide, with an exceedingly low 5-year survival rate. PDAC tumors are characterized by an extensive desmoplastic stromal response and hypovascularity, s…
Data from <i>Hif1a</i> Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia Open
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths worldwide, with an exceedingly low 5-year survival rate. PDAC tumors are characterized by an extensive desmoplastic stromal response and hypovascularity, s…
View article: Data from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Data from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal cells using CAR T cells may offer several advantages. We develo…
View article: Supplementary Methods from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Supplementary Methods from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
PDF file - 135K
View article: Supplementary Figures 1 - 9 from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Supplementary Figures 1 - 9 from Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity Open
PDF file - 1196K, Supplementary Figure 1. Phenotypic analysis of FAP+ stromal cells in untreated TC1 flank tumors in C57BL/6 mice. Supplementary Figure 2. Depletion of FAP+ cells. Supplementary Figure 3. Persistence and antitumor activitie…
Supplementary Figure 6 from Heterozygosity for <i>Hypoxia Inducible Factor 1α</i> Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model Open
Supplementary Figure 6 from Heterozygosity for Hypoxia Inducible Factor 1α Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model
Supplementary Figure 1 from Heterozygosity for <i>Hypoxia Inducible Factor 1α</i> Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model Open
Supplementary Figure 1 from Heterozygosity for Hypoxia Inducible Factor 1α Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model
Supplementary Table 1 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells Open
Reagents for immunohistochemistry studies.
Supplementary Figure 2 from Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy Open
PDF file - 3.4MB
Supplementary Figure 5 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells Open
Analysis of immune infiltrating cells in 4662 tumors following FAP-CAR Therapy.
Supplementary Figure 1 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells Open
Identification of FAP+ cancer-associated stromal cells in desmoplastic A549 tumors.
Supplementary Materials and Methods from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells Open
Supplementary materials and methods.
Supplementary Table 1 from Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner Open
Supplementary Table 1 from Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner
Supplementary Figure 6 from Heterozygosity for <i>Hypoxia Inducible Factor 1α</i> Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model Open
Supplementary Figure 6 from Heterozygosity for Hypoxia Inducible Factor 1α Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model
Supplementary Figure 1 from Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy Open
PDF file - 4.7MB