Charlotte E. Egan
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View article: CCR2 and CD44 Promote Inflammatory Cell Recruitment during Fatty Liver Formation in a Lithogenic Diet Fed Mouse Model
CCR2 and CD44 Promote Inflammatory Cell Recruitment during Fatty Liver Formation in a Lithogenic Diet Fed Mouse Model Open
Non-alcoholic fatty liver disease (NAFLD) is a common disease with a spectrum of presentations. The current study utilized a lithogenic diet model of NAFLD. The diet was fed to mice that are either resistant (AKR) or susceptible (BALB/c an…
View article: Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis
Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis Open
Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is the primary regulator of mitochondrial biogenesis and was recently found to be highly expressed within the intestinal epithelium. PGC1α is decreased in the intestinal …
View article: Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis
Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis Open
The nature and role of the intestinal leukocytes in necrotizing enterocolitis (NEC), a severe disease affecting premature infants, remain unknown. We now show that the intestine in mouse and human NEC is rich in lymphocytes that are requir…
View article: Paneth cells produce Ang4 in response to IL‑22 of which γδ iIELs are a source.
Paneth cells produce Ang4 in response to IL‑22 of which γδ iIELs are a source. Open
(A) ELISA-determined Ang4 protein levels produced by small intestinal crypts (2x103) from TCRδ-/- mice after culture at 37°C for 4h in media alone (Medium) or in media containing PMA/Io. Additional crypt samples were cultured with 103 WT i…
View article: Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut
Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut Open
The mechanisms that lead to the development of remote lung injury after trauma remain unknown, although a central role for the gut in the induction of lung injury has been postulated. We hypothesized that the development of remote lung inj…