Matt Jones
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View article: Lecanemab appropriate use recommendations for clinical practice in the UK
Lecanemab appropriate use recommendations for clinical practice in the UK Open
Lecanemab is an anti-amyloid monoclonal antibody, recently approved in the UK as a treatment for mild cognitive impairment (MCI) and mild dementia due to Alzheimer’s disease (AD) in adults who are apolipoprotein E ε4 gene ( APOE4 ) heteroz…
View article: Mandatory specialist approval requirements reduce valproate prescribing: population-based evaluation of a National Patient Safety Alert
Mandatory specialist approval requirements reduce valproate prescribing: population-based evaluation of a National Patient Safety Alert Open
Background Valproate exposure during pregnancy causes major congenital malformations in 11% and neurodevelopmental disorders in 30–40% of exposed children. Despite regulatory interventions, including the European 2018 Pregnancy Prevention …
View article: Matrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation
Matrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation Open
Summary Microenvironmental stiffness regulates fundamental aspects of cell behaviour, including proliferation, differentiation and metabolism, many of which are implicated in cancer initiation and progression. In the mammary gland, extrace…
View article: Differential roles of cyclin–CDK1 complexes in cell migration and invasion
Differential roles of cyclin–CDK1 complexes in cell migration and invasion Open
We have previously described a central role for CDK1 at the nexus of adhesion signalling and cell cycle progression, demonstrating that CDK1 has a non-canonical role in regulating integrin adhesion complexes and in the migration of cancer …
View article: Multiplexed proximity labelling proteomics identifies a non-canonical Bcl-2 family interactome associated with apoptotic priming
Multiplexed proximity labelling proteomics identifies a non-canonical Bcl-2 family interactome associated with apoptotic priming Open
Bcl-2 family proteins govern the intrinsic apoptotic pathway by regulating mitochondrial outer membrane permeabilisation (MOMP), releasing apoptogenic factors into the cytosol. How close a cell is to MOMP, termed mitochondrial priming, is …
View article: Interleukin-4 modulates type I interferon to augment antitumor immunity
Interleukin-4 modulates type I interferon to augment antitumor immunity Open
Despite advances in immunotherapy, metastatic melanoma remains a considerable therapeutic challenge due to the complexity of the tumor microenvironment. Intratumoral type I interferon (IFN-I) has long been associated with improved clinical…
View article: A novel computational method for rodent electrographic recording and analysis using off-the-shelf intracerebral depth electrodes
A novel computational method for rodent electrographic recording and analysis using off-the-shelf intracerebral depth electrodes Open
Electrographic recording of brain activity through either surface electrodes (electroencephalography, EEG) or implanted electrodes (electrocorticography, ECOG) are valuable research tools in neuroscience across many disciplines, including …
View article: Differential roles of cyclin-CDK1 complexes in cell migration and invasion
Differential roles of cyclin-CDK1 complexes in cell migration and invasion Open
Two key hallmarks of cancer are dysregulated proliferation and metastasis, which are co- ordinated at the single cell level by regulation of cell-cycle progression and invasive cell migration respectively. We have previously described a ce…
View article: Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes
Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes Open
Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response. Using murine models that exclud…
View article: Cell cycle control by cell-matrix interactions
Cell cycle control by cell-matrix interactions Open
Cell adhesion to the extracellular matrix (ECM) is required for normal cell cycle progression and accurate cell division. However, how cell adhesion to the wide range of ECM proteins found in human tissues influences the cell cycle is not …
View article: Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters
Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters Open
Endosomal Sorting Complex Required for Transport (ESCRT) proteins can be transiently recruited to the plasma membrane for membrane repair and formation of extracellular vesicles. Here, we discovered micrometer-sized worm-shaped ESCRT struc…
View article: Extended depth-of-field light-sheet microscopy improves imaging of large volumes at high numerical aperture
Extended depth-of-field light-sheet microscopy improves imaging of large volumes at high numerical aperture Open
Light-sheet microscopes must compromise between field of view, optical sectioning, resolution, and detection efficiency. High-numerical-aperture (NA) detection objective lenses provide high resolution but their narrow depth of field fails …
View article: Early clonal expansion of tumor-infiltrating lymphocytes predicts response to immune checkpoint therapy
Early clonal expansion of tumor-infiltrating lymphocytes predicts response to immune checkpoint therapy Open
Immune checkpoint therapy (ICT) causes durable tumor responses in a subgroup of patients. Profiling T cell receptor beta (TCRβ) repertoire structure in ICT responders and non-responders provides mechanistic insight into what constitutes an…
View article: Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation
Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation Open
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical intervention. Together wit…
View article: Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation
Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation Open
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical intervention. Together wit…
View article: Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1 Open
Talin is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behaviour of its multiple rod domains that modulate interactions with …
View article: Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration
Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration Open
Cell migration in 3D microenvironments is a complex process which depends on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mechanism. While the potentiation of protrusions has been widely stud…
View article: Increased microenvironment stiffness leads to altered aldehyde metabolism and DNA damage in mammary epithelial cells through a RhoA-dependent mechanism
Increased microenvironment stiffness leads to altered aldehyde metabolism and DNA damage in mammary epithelial cells through a RhoA-dependent mechanism Open
Summary Microenvironmental stiffness regulates the behaviour of both normal and cancer cells. In breast tissue, high mammographic density (HMD), which reflects greater organisation and stiffness of the periductal collagen, represents a sig…
View article: Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration
Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration Open
Cell migration in 3D micro-environments is a complex process which depends on the coordinated activity of leading edge protrusive force and rear retraction in a push-pull mechanism. While the potentiation of protrusions has been widely stu…
View article: Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation
Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation Open
Integrin adhesion complexes (IACs) bridge the extracellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mechanical cues. The composition, interactions, stoichiometry, and topological organization…
View article: Definition of the fibroblast adhesome using multiplexed proximity biotinylation
Definition of the fibroblast adhesome using multiplexed proximity biotinylation Open
Integrin adhesion complexes (IACs) bridge the extracellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mechanical cues. The composition, interactions, stoichiometry and topological organisation …
View article: Connections between the cell cycle, cell adhesion and the cytoskeleton
Connections between the cell cycle, cell adhesion and the cytoskeleton Open
Cell division, the purpose of which is to enable cell replication, and in particular to distribute complete, accurate copies of genetic material to daughter cells, is essential for the propagation of life. At a morphological level, divisio…
View article: Clathrin-containing adhesion complexes
Clathrin-containing adhesion complexes Open
An understanding of the mechanisms whereby cell adhesion complexes (ACs) relay signals bidirectionally across the plasma membrane is necessary to interpret the role of adhesion in regulating migration, differentiation, and growth. A range …