Charles G. Eberhart
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View article: Spinal cord neuromodulation for blood pressure control using low-intensity focused ultrasound
Spinal cord neuromodulation for blood pressure control using low-intensity focused ultrasound Open
Focused ultrasound (FUS) is an innovative technology that delivers angled acoustic energy to a small target region. Previous FUS technology has demonstrated efficacy in applications such as tumor destruction, nerve modulation, and drug del…
View article: <i>RECQL4</i> alterations in gliomas and nerve sheath tumors: Expression patterns and therapeutic implications
<i>RECQL4</i> alterations in gliomas and nerve sheath tumors: Expression patterns and therapeutic implications Open
RECQL4 plays an important role in maintaining the integrity of the genome and regulating DNA replication. However, the role of RECQL4 in CNS tumors remains unknown. Sequencing data were reviewed and immunohistochemistry was performed on a …
View article: P10.02.A CAR-T CELL-DERIVED EXOSOMES LOADED WITH THERAPEUTIC SIRNA IS A PROMISING TECHNIQUE IN THE TREATMENT OF SUBGROUP 3 MEDULLOBLASTOMA
P10.02.A CAR-T CELL-DERIVED EXOSOMES LOADED WITH THERAPEUTIC SIRNA IS A PROMISING TECHNIQUE IN THE TREATMENT OF SUBGROUP 3 MEDULLOBLASTOMA Open
BACKGROUND Medulloblastoma (MB) is a life-threatening childhood tumor that occurs in the cerebellum. This tumor showed resistance against several types of immunotherapies like anti-PD1, cancer vaccines, monoclonal antibodies (mAbs), and ev…
View article: Pineal parenchymal tumor in a domestic rabbit
Pineal parenchymal tumor in a domestic rabbit Open
An 11-y-old male lionhead rabbit ( Oryctolagus cuniculus ) was presented with progressive hindlimb weakness and right-sided neurologic deficits, and was subsequently euthanized due to poor prognosis. Autopsy revealed a 1.6 × 1.1 × 1.0-cm, …
View article: Correction: Lee et al. Establishment and Characterization of Three Human Ocular Adnexal Sebaceous Carcinoma Cell Lines. Int. J. Mol. Sci. 2024, 25, 10183
Correction: Lee et al. Establishment and Characterization of Three Human Ocular Adnexal Sebaceous Carcinoma Cell Lines. Int. J. Mol. Sci. 2024, 25, 10183 Open
In the original publication [...]
View article: Long-Term Observations of the First Human Implantation of an Artificial Endothelial Layer for Endothelial Dysfunction: A Pilot Study
Long-Term Observations of the First Human Implantation of an Artificial Endothelial Layer for Endothelial Dysfunction: A Pilot Study Open
Purpose: To describe the long-term observations of the first human implantation of EndoArt, a synthetic endothelial implant, in a small cohort of patients with corneal edema secondary to endothelial dysfunction. Methods: This retrospective…
View article: BSBM-02 WNT5A MEDIATES MELANOMA BRAIN METASTASIS
BSBM-02 WNT5A MEDIATES MELANOMA BRAIN METASTASIS Open
Melanoma brain metastasis (MBM) leads to significant morbidity and mortality. Building on previous findings that WNT5A regulates melanoma metastasis and dormancy in extracranial niches, we hypothesize that WNT5A signaling facilitates melan…
View article: Developing a zebrafish xenograft model of diffuse midline glioma
Developing a zebrafish xenograft model of diffuse midline glioma Open
Diffuse midline glioma (DMG) is a highly aggressive brain tumor that predominantly affects children. Conventional treatments such as radiation therapy can control progression for a time, but DMG kills nearly 100 percent of patients. Althou…
View article: Retinal and Choriocapillaris Thickness Changes in Spontaneously Diabetic Macaques
Retinal and Choriocapillaris Thickness Changes in Spontaneously Diabetic Macaques Open
Consistent with humans, early diabetes in cynomolgus macaques results in notable alterations in retinal thickness, particularly affecting the nasal inner retina. The observed increase in choriocapillaris thickness in both diabetic macaques…
View article: Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus
Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus Open
We provide a molecular explanation for how mechanical strain results in reduced expression of WNT10A in the corneal epithelium, which, in turn, leads to depletion of collagen type I and XII, and TGFβ1 expression. These results provide a mo…
View article: Increased SOX10, p16, and Cyclin D1 Immunoreactivity Differentiates MAP Kinase-activated Low-grade Gliomas From Piloid Gliosis
Increased SOX10, p16, and Cyclin D1 Immunoreactivity Differentiates MAP Kinase-activated Low-grade Gliomas From Piloid Gliosis Open
Low-grade gliomas and reactive piloid gliosis can present with overlapping features on conventional histology. Given the large implications for patient treatment, there is a need for effective methods to discriminate these morphologically …
View article: The CoREST complex inhibitor, corin, leads to decreased tumor growth, increased cellular differentiation and extended lifespan in atypical teratoid rhabdoid tumor xenograft models
The CoREST complex inhibitor, corin, leads to decreased tumor growth, increased cellular differentiation and extended lifespan in atypical teratoid rhabdoid tumor xenograft models Open
Background Atypical teratoid rhabdoid tumor (ATRT) is the most common malignant brain tumor in infants, and more than 60% of children with ATRT die from their tumor. ATRT is associated with mutational inactivation/deletion of SMARCB1 , a m…
View article: High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX Deficiency
High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX Deficiency Open
Neurofibromatosis type 1 (NF1)-associated high-grade gliomas (HGGs) harboring ATRX mutations exhibit an aggressive clinical phenotype, driven by heightened genomic instability and metabolic reprogramming. Existing therapies, including chem…
View article: CNSC-43. NEUROTRANSMITTER DEPENDENCY UNDERLIES TUMOR GROWTH IN HUMANIZED PEDIATRIC LOW-GRADE GLIOMA MODELS
CNSC-43. NEUROTRANSMITTER DEPENDENCY UNDERLIES TUMOR GROWTH IN HUMANIZED PEDIATRIC LOW-GRADE GLIOMA MODELS Open
Brain tumors arise in close association with neurons, suggesting that these non-neoplastic cells may be critical stromal drivers of brain tumor initiation and growth. Previously, we have shown that murine low-grade optic glioma formation a…
View article: Establishment and Characterization of Three Human Ocular Adnexal Sebaceous Carcinoma Cell Lines
Establishment and Characterization of Three Human Ocular Adnexal Sebaceous Carcinoma Cell Lines Open
Ocular adnexal sebaceous carcinoma (SebCA) represents one of the most clinically problematic periocular tumors, often requiring aggressive surgical resection. The pathobiology of this tumor remains poorly understood, and few models exist t…
View article: Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond
Toward standardized brain tumor tissue processing protocols in neuro-oncology: a perspective for gliomas and beyond Open
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently r…
View article: Radiation immunodynamics in patients with glioblastoma receiving chemoradiation
Radiation immunodynamics in patients with glioblastoma receiving chemoradiation Open
Introduction This is a prospective, rigorous inquiry into the systemic immune effects of standard adjuvant chemoradiotherapy, for WHO grade 4, glioblastoma. The purpose is to identify peripheral immunologic effects never yet reported in ke…
View article: Brain Nucleic Acid Delivery and Genome Editing via Focused Ultrasound-Mediated Blood–Brain Barrier Opening and Long-Circulating Nanoparticles
Brain Nucleic Acid Delivery and Genome Editing via Focused Ultrasound-Mediated Blood–Brain Barrier Opening and Long-Circulating Nanoparticles Open
We introduce a two-pronged strategy comprising focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening and long-circulating biodegradable nanoparticles (NPs) for systemic delivery of nucleic acids to the brain. Biodegradable po…
View article: VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma
VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma Open
Background: Relapsed medulloblastoma (MB) poses a significant therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Immune checkpoint inhibitors (ICIs) have struggled to mitigate this challenge, largely due to l…
View article: VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma
VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma Open
Background: Relapsed medulloblastoma (MB) poses a significant therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Immune checkpoint inhibitors (ICIs) have struggled to mitigate this challenge, largely due to l…
View article: ATRT-17. INHIBITING THE MAP KINASE PATHWAY WITH MEK INHIBITOR MIRDAMETINIB SUPPRESSES CANCER GROWTH IN ATYPICAL TERATOID/RHABDOID TUMORS
ATRT-17. INHIBITING THE MAP KINASE PATHWAY WITH MEK INHIBITOR MIRDAMETINIB SUPPRESSES CANCER GROWTH IN ATYPICAL TERATOID/RHABDOID TUMORS Open
BACKGROUND Atypical teratoid/rhabdoid tumors (ATRT) are poor-prognosis infantile brain tumors. Our prior studies examining ATRT primary tissues have shown an increased expression of phospho-ERK, a downstream effector of MEK in the mitogen-…
View article: MDB-70. SYSTEMATIC TRANSCRIPTOMIC ANALYSIS OF CHILDHOOD MEDULLOBLASTOMA IDENTIFIES M6A-LNCRNA SIGNATURES ASSOCIATED WITH PROGNOSIS, MOLECULAR SUBTYPE, AND IMMUNE CELL INFILTRATION
MDB-70. SYSTEMATIC TRANSCRIPTOMIC ANALYSIS OF CHILDHOOD MEDULLOBLASTOMA IDENTIFIES M6A-LNCRNA SIGNATURES ASSOCIATED WITH PROGNOSIS, MOLECULAR SUBTYPE, AND IMMUNE CELL INFILTRATION Open
BACKGROUND Medulloblastoma (MB) is the predominant pediatric brain tumor, subdivided into four molecular subgroups, with group 3 and group 4 tumors posing significant clinical challenges due to poor prognosis and classification. This study…
View article: DIPG-58. TARGETING DISORDERED DNA METHYLATION IN DIPG TO CONSTRAIN VARIABILITY AND INDUCE IMMUNE SIGNALING
DIPG-58. TARGETING DISORDERED DNA METHYLATION IN DIPG TO CONSTRAIN VARIABILITY AND INDUCE IMMUNE SIGNALING Open
BACKGROUND Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal pediatric brain cancer characterized by the histone H3 K27M mutation. The known downstream consequences of this mutation include loss of repressive chromatin marks, …
View article: MDB-01. A POSITIVE FEEDBACK LOOP BETWEEN<i>LNC-HLX-2-7</i>, HLX, AND MYC STRONGLY PROMOTES GROUP 3 MEDULLOBLASTOMA
MDB-01. A POSITIVE FEEDBACK LOOP BETWEEN<i>LNC-HLX-2-7</i>, HLX, AND MYC STRONGLY PROMOTES GROUP 3 MEDULLOBLASTOMA Open
Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma formation and progression. We have identified a lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) medulloblastomas. lnc-HLX-2-7 R…
View article: OTHR-16. HYPERACTIVATION OF THE INTEGRATED STRESS RESPONSE VIA PROTEASOME INHIBITION KILLS DMG AND ATRT WHILE SPARING NORMAL IPSC BRAIN ORGANOIDS
OTHR-16. HYPERACTIVATION OF THE INTEGRATED STRESS RESPONSE VIA PROTEASOME INHIBITION KILLS DMG AND ATRT WHILE SPARING NORMAL IPSC BRAIN ORGANOIDS Open
BACKGROUND H3K27-altered diffuse midline glioma (DMG) and atypical teratoid/rhabdoid tumor (ATRT) have increased baseline activation of the integrated stress response (ISR), an evolutionarily conserved system that enables cells to tolerate…