C. Edward Dixon
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View article: Perinatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters Goal-Directed Behavior and Dopamine Functioning in Wistar Rats
Perinatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters Goal-Directed Behavior and Dopamine Functioning in Wistar Rats Open
Rationale : Cannabis use during pregnancy is common as many pregnant women consider cannabis as a safe way to alleviate symptoms associated with pregnancy because it is “natural”. However, clinical evidence links perinatal cannabis exposur…
View article: Perinatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters Goal-Directed Behavior and Dopamine Functioning in Wistar Rats
Perinatal Exposure to Delta-9-tetrahydrocannabinol (THC) Alters Goal-Directed Behavior and Dopamine Functioning in Wistar Rats Open
Cannabis use during pregnancy is common as many pregnant women consider cannabis as a safe way to alleviate symptoms associated with pregnancy because it is “natural”. However, clinical evidence links perinatal exposure to cannabis to exte…
View article: Assessment of Neurobehavioral Performance and Markers of Synaptic Vesicle Trafficking in an Alpha-Synuclein Knockout Mouse Model after Controlled Cortical Impact Injury
Assessment of Neurobehavioral Performance and Markers of Synaptic Vesicle Trafficking in an Alpha-Synuclein Knockout Mouse Model after Controlled Cortical Impact Injury Open
Traumatic brain injury (TBI) is associated with significant deficits across cognitive, emotional, and somatic functions, contributing to reduced quality of life for TBI survivors. Synaptic vesicle cycling, crucial for neurotransmitter rele…
View article: Systemic treatment with ubiquitin carboxy terminal hydrolase L1 TAT protein ameliorates axonal injury and reduces functional deficits after traumatic brain injury in mice
Systemic treatment with ubiquitin carboxy terminal hydrolase L1 TAT protein ameliorates axonal injury and reduces functional deficits after traumatic brain injury in mice Open
View article: Experimental traumatic brain injury increases epichaperome formation
Experimental traumatic brain injury increases epichaperome formation Open
View article: Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis
Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis Open
View article: Assessment of behavioral, neuroinflammatory, and histological responses in a model of rat repetitive mild fluid percussion injury at 2 weeks post-injury
Assessment of behavioral, neuroinflammatory, and histological responses in a model of rat repetitive mild fluid percussion injury at 2 weeks post-injury Open
Repetitive mild traumatic brain injury (rmTBI) is a prominent public health concern, with linkage to debilitating chronic sequelae. Developing reliable and well-characterized preclinical models of rmTBI is imperative in the investigation o…
View article: Endogenous Interleukin-17a Contributes to Normal Spatial Memory Retention but Does Not Affect Early Behavioral or Neuropathological Outcomes after Experimental Traumatic Brain Injury
Endogenous Interleukin-17a Contributes to Normal Spatial Memory Retention but Does Not Affect Early Behavioral or Neuropathological Outcomes after Experimental Traumatic Brain Injury Open
Interleukin-17 (IL-17) is a proinflammatory cytokine primarily secreted in the brain by inflammatory T lymphocytes and glial cells. IL-17 + T-helper (Th17) cells are increased in the ipsilateral hemisphere after experimental traumatic brai…
View article: All-Trans Retinoic Acid Dose Response to Evaluate Therapeutic Effects on Cognition and Hippocampal Protein Expression after Controlled Cortical Impact
All-Trans Retinoic Acid Dose Response to Evaluate Therapeutic Effects on Cognition and Hippocampal Protein Expression after Controlled Cortical Impact Open
View article: Mutation of a Ubiquitin Carboxy Terminal Hydrolase L1 Lipid Binding Site Alleviates Cell Death, Axonal Injury, and Behavioral Deficits After Traumatic Brain Injury in Mice
Mutation of a Ubiquitin Carboxy Terminal Hydrolase L1 Lipid Binding Site Alleviates Cell Death, Axonal Injury, and Behavioral Deficits After Traumatic Brain Injury in Mice Open
View article: Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury
Reductions in Synaptic Vesicle Glycoprotein 2 Isoforms in the Cortex and Hippocampus in a Rat Model of Traumatic Brain Injury Open
View article: Spatial Distribution of Neuropathology and Neuroinflammation Elucidate the Biomechanics of Fluid Percussion Injury
Spatial Distribution of Neuropathology and Neuroinflammation Elucidate the Biomechanics of Fluid Percussion Injury Open
Diffuse brain injury is better described as multi-focal, where pathology can be found adjacent to seemingly uninjured neural tissue. In experimental diffuse brain injury, pathology and pathophysiology have been reported far more lateral th…
View article: Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases
Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases Open
Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury mechanism, underlying conditions, and secondary injury. Pre-clinical and clinical researchers face challenges with reproducibility that negativel…
View article: Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice
Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice Open
View article: Spatial distribution of neuropathology and neuroinflammation elucidate the biomechanics of fluid percussion injury
Spatial distribution of neuropathology and neuroinflammation elucidate the biomechanics of fluid percussion injury Open
Diffuse brain injury is better described as multi-focal, where pathology can be found adjacent to seemingly uninjured neural tissue. In experimental diffuse brain injury, pathology and pathophysiology have been reported far more lateral th…
View article: Differential Regional Responses in Soluble Monomeric Alpha Synuclein Abundance Following Traumatic Brain Injury
Differential Regional Responses in Soluble Monomeric Alpha Synuclein Abundance Following Traumatic Brain Injury Open
View article: Neurogranin Protein Expression Is Reduced after Controlled Cortical Impact in Rats
Neurogranin Protein Expression Is Reduced after Controlled Cortical Impact in Rats Open
Traumatic brain injury (TBI) is known to cause short- and long-term synaptic changes in the brain, possibly underlying downstream cognitive impairments. Neuronal levels of neurogranin, a calcium-sensitive calmodulin-binding protein essenti…
View article: Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex
Extended (10-Day) Real-Time Monitoring by Dexamethasone-Enhanced Microdialysis in the Injured Rat Cortex Open
Intracerebral microdialysis has proven useful for chemical monitoring in patients following traumatic brain injury. Recent studies in animals, however, have documented that insertion of microdialysis probes into brain tissues initiates a f…
View article: Primum non nocere: a call for balance when reporting on CTE
Primum non nocere: a call for balance when reporting on CTE Open
View article: Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision
Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision Open
New neuroprotective therapies for severe traumatic brain injury (TBI) have not translated from pre-clinical to clinical success. Numerous explanations have been suggested in both the pre-clinical and clinical arenas. Coverage of TBI in the…
View article: Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond
Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond Open
Current approaches have failed to yield success in the translation of neuroprotective therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous explanations have been put forth in both the pre-clinica…
View article: Novel therapies for combating chronic neuropathological sequelae of TBI
Novel therapies for combating chronic neuropathological sequelae of TBI Open
View article: Melatonin as a Therapy for Traumatic Brain Injury: A Review of Published Evidence
Melatonin as a Therapy for Traumatic Brain Injury: A Review of Published Evidence Open
Melatonin (MEL) is a hormone that is produced in the brain and is known to bind to MEL-specific receptors on neuronal membranes in several brain regions. MEL’s documented neuroprotective properties, low toxicity, and ability to cross the b…
View article: Pre-Clinical Testing of Therapies for Traumatic Brain Injury
Pre-Clinical Testing of Therapies for Traumatic Brain Injury Open
Despite the large number of promising neuroprotective agents identified in experimental traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long-term outcome in clinical trials. To develop recommendations an…
View article: Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice
Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice Open
View article: Operation Brain Trauma Therapy: 2016 Update
Operation Brain Trauma Therapy: 2016 Update Open
Operation brain trauma therapy (OBTT) is a multi-center, pre-clinical drug and biomarker screening consortium for traumatic brain injury (TBI). Therapies are screened across three rat models (parasagittal fluid percussion injury, controlle…
View article: Lateral Fluid Percussion Injury Impairs Hippocampal Synaptic Soluble N-Ethylmaleimide Sensitive Factor Attachment Protein Receptor Complex Formation
Lateral Fluid Percussion Injury Impairs Hippocampal Synaptic Soluble N-Ethylmaleimide Sensitive Factor Attachment Protein Receptor Complex Formation Open
Traumatic brain injury (TBI) and the activation of secondary injury mechanisms have been linked to impaired cognitive function, which, as observed in TBI patients and animal models, can persist for months and years following the initial in…
View article: Mini Review of Controlled Cortical Impact: A Well-Suited Device for Concussion Research
Mini Review of Controlled Cortical Impact: A Well-Suited Device for Concussion Research Open
Mild traumatic brain injury (mTBI) is increasingly recognized as a significant public health problem which warrants additional research. Part of the effort to understand mTBI and concussion includes modeling in animals. Controlled cortical…
View article: In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury
In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury Open
Many mechanisms or pathways are involved in secondary post-traumatic brain injury, such as the ubiquitin-proteasome pathway (UPP), axonal degeneration and neuronal cell apoptosis. UCH-L1 is a protein that is expressed in high levels in neu…
View article: Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2
Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2 Open