C. Elizabeth Boudreau
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View article: MRI findings in six dogs with ependymoma of the brain and spinal cord
MRI findings in six dogs with ependymoma of the brain and spinal cord Open
There are few published descriptions of the MRI appearance of canine intracranial or spinal cord ependymoma. In this multicenter, retrospective, secondary analysis, case series study, three veterinary radiologists independently reviewed an…
View article: Canine medial retropharyngeal lymph node measurements on T2 spin-echo sequences at 3T
Canine medial retropharyngeal lymph node measurements on T2 spin-echo sequences at 3T Open
Introduction The objective of this study is to estimate reference values for medial retropharyngeal lymph nodes (MRLNs) measured in high-field (3T) MRI studies of the canine head/brain using transverse T2 spin-echo images and to determine …
View article: Supplementary Table 1 from Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
Supplementary Table 1 from Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma Open
Imaging Technique
View article: Data from Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
Data from Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma Open
Purpose:Activation of STING (stimulator of interferon genes) can trigger a robust, innate antitumor immune response in immunologically “cold” tumors such as glioblastoma.Patients and Methods:A small-molecule STING agonist, IACS-8779, was s…
View article: Association of the <scp><i>FGF4L2</i></scp> retrogene with fibrocartilaginous embolic myelopathy in dogs
Association of the <span><i>FGF4L2</i></span> retrogene with fibrocartilaginous embolic myelopathy in dogs Open
Background Fibrocartilaginous embolic myelopathy (FCE) is a well‐documented condition in dogs although rarely reported in chondrodystrophic breeds. Genetic associations have not been defined. Objectives Define the association of the chondr…
View article: Issue Information
Issue Information Open
Intramural esophageal location of a portosystemic shunt in a dog with two congenital portosystemic shunts on CT angiography
View article: The “Claw Sign” may aid in axial localization in cases of peripherally located canine glioma on MRI
The “Claw Sign” may aid in axial localization in cases of peripherally located canine glioma on MRI Open
The “claw sign” is a radiographic sign studied in human imaging to determine if a mass arises from a solid structure or organ versus a close adjacent location, resulting in distortion of the outline of an organ. We investigated its utility…
View article: Temporal and sequence-related variability in diffusion-weighted imaging of presumed cerebrovascular accidents in the dog brain
Temporal and sequence-related variability in diffusion-weighted imaging of presumed cerebrovascular accidents in the dog brain Open
Diffusion-weighted MRI (DWI) is often used to guide clinical interpretation of intraparenchymal brain lesions when there is suspicion for a cerebrovascular accident (CVA). Despite widespread evidence that imaging and patient parameters can…
View article: Randomized clinical trial comparing outcomes after fentanyl or ketamine‐dexmedetomidine analgesia in thoracolumbar spinal surgery in dogs
Randomized clinical trial comparing outcomes after fentanyl or ketamine‐dexmedetomidine analgesia in thoracolumbar spinal surgery in dogs Open
Background Opioids are widely used for perioperative pain control in dogs undergoing spinal surgery, but alternatives may be required because data suggest that opioids exacerbate inflammation in the injured spinal cord and veterinary acces…
View article: Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation
Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation Open
OBJECTIVE To investigate the time course of circulating neutrophil priming and activity in dogs with spinal cord injury secondary to intervertebral disk herniation that undergo decompressive surgery. ANIMALS 9 dogs with spinal cord injury …
View article: Subclinical Hypoventilation in Dogs Undergoing Ventral Slot Decompressive Surgery for Cervical Myelopathy Due to Intervertebral Disc Herniation
Subclinical Hypoventilation in Dogs Undergoing Ventral Slot Decompressive Surgery for Cervical Myelopathy Due to Intervertebral Disc Herniation Open
The objective of this prospective cohort study was to document the occurrence of post-operative hypoventilation in dogs undergoing decompressive ventral slot or hemilaminectomy for the treatment of intervertebral disc herniation (IVDH). Tw…
View article: Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma Open
Purpose: Activation of STING (stimulator of interferon genes) can trigger a robust, innate antitumor immune response in immunologically “cold” tumors such as glioblastoma. Patients and Methods: A small-molecule STING agonist, IACS-8779, wa…
View article: Veterinary <scp>Cooperative</scp> Oncology Group—Common Terminology Criteria for Adverse Events (<scp>VCOG‐CTCAE</scp> v2) following investigational therapy in dogs and cats
Veterinary <span>Cooperative</span> Oncology Group—Common Terminology Criteria for Adverse Events (<span>VCOG‐CTCAE</span> v2) following investigational therapy in dogs and cats Open
The updated VCOG‐CTCAE v2 guidelines contain several important updates and additions since the last update (v1.1) was released in 2011 and published within Veterinary and Comparative Oncology in 2016. As the Veterinary Cooperative Oncology…
View article: Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients
Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients Open
On September 14–15, 2015, a meeting of clinicians and investigators in the fields of veterinary and human neuro-oncology, clinical trials, neuropathology, and drug development was convened at the National Institutes of Health campus in Bet…
View article: Extended durotomy to treat severe spinal cord injury after acute thoracolumbar disc herniation in dogs
Extended durotomy to treat severe spinal cord injury after acute thoracolumbar disc herniation in dogs Open
Objective To report recovery of ambulation of dogs treated with extended thoracolumbar durotomy for severe spinal cord injury caused by intervertebral disc herniation. Study design Descriptive cohort. Animals Twenty‐six consecutive paraple…
View article: Comparative molecular life history of spontaneous canine and human gliomas
Comparative molecular life history of spontaneous canine and human gliomas Open
Summary Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to cha…
View article: Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury
Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury Open
Background Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. The…
View article: Peer Review #1 of "Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury (v0.1)"
Peer Review #1 of "Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury (v0.1)" Open
Background.Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans.Ther…
View article: Putative Cerebral Microbleeds in Dogs Undergoing Magnetic Resonance Imaging of the Head: A Retrospective Study of Demographics, Clinical Associations, and Relationship to Case Outcome
Putative Cerebral Microbleeds in Dogs Undergoing Magnetic Resonance Imaging of the Head: A Retrospective Study of Demographics, Clinical Associations, and Relationship to Case Outcome Open
Background Cerebral microbleeds ( CMB s) are focal intraparenchymal signal voids on gradient‐echo magnetic resonance imaging (MRI), corresponding to regions of chronic hemorrhage. In humans, they are associated with systemic disease and sh…
View article: Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury
Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury Open
Arachidonic acid metabolism is altered in dogs with SCI, and these data suggest that these AA metabolites reflect injury severity and recovery, paralleling data from other model systems.
View article: Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients
Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients Open
On September 14-15, 2015, a meeting of clinicians and investigators in the fields of veterinary and human neuro-oncology, clinical trials, neuropathology, and drug development was convened at the National Institutes of Health campus in Bet…