Esteban C. Gabazza
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View article: First Report of <scp> <i>RET</i> </scp> Fusion‐Positive Lung Adenocarcinoma With Miliary Intrapulmonary Metastases Responsive to Selpercatinib: A Case Report
First Report of <span> <i>RET</i> </span> Fusion‐Positive Lung Adenocarcinoma With Miliary Intrapulmonary Metastases Responsive to Selpercatinib: A Case Report Open
Lung cancer presenting with miliary lung metastases on chest computed tomography is associated with poor prognosis. Recent studies indicate that non‐small cell lung cancer harboring driver gene mutations, including rearranged during transf…
View article: Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging Open
View article: Pathogen detection by multiplex PCR: A comparative study of pneumonia panel, bacterial culture, and respiratory panel in Japanese patients
Pathogen detection by multiplex PCR: A comparative study of pneumonia panel, bacterial culture, and respiratory panel in Japanese patients Open
The pneumonia panel showed superior pathogen detection compared to bacterial culture, reinforcing its clinical value in pneumonia management. Comparable viral detection between pneumonia and respiratory panels suggests diagnostic interchan…
View article: Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly
Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly Open
Aurora‐A (AurA) is a member of the mitotic kinase family and is highly expressed in various tumors. Inhibition of AurA generally leads to fetal mitotic errors. We previously reported that AurA inhibition induces G 0 /G 1 cell cycle arrest …
View article: Suitability of Specimens from Pleural Dissemination of Non-Small Cell Lung Cancer for Genetic Testing Using Forceps and Cryobiopsy
Suitability of Specimens from Pleural Dissemination of Non-Small Cell Lung Cancer for Genetic Testing Using Forceps and Cryobiopsy Open
Introduction: Pleuroscopy has significantly improved the diagnostic yield for pleural diseases, including lung cancer with pleural dissemination. However, obtaining suitable samples for genetic analysis in non-small cell lung cancer (NSCLC…
View article: Endoplasmic reticulum stress-related genes contribute to lung cancer risk: a multiomics data integration study
Endoplasmic reticulum stress-related genes contribute to lung cancer risk: a multiomics data integration study Open
This study systematically investigated the causal relationship between ERS-related genes and lung cancer risk, revealing that elevated expression of KLC1 and BCL2L1 may contribute to increased lung cancer risk and be associat…
View article: Exploratory Evaluation of Circulating Microbiota-Derived Corisin Levels in Women with Adverse Pregnancy Outcomes
Exploratory Evaluation of Circulating Microbiota-Derived Corisin Levels in Women with Adverse Pregnancy Outcomes Open
Preterm birth and low birth weight remain major contributors to neonatal morbidity and mortality, yet the underlying mechanisms are not fully understood. Maternal microbiota has been implicated in adverse pregnancy outcomes, but key mediat…
View article: The Impact of Comorbidities on Serum IgG Levels and Exacerbation Risk in Chronic Obstructive Pulmonary Disease
The Impact of Comorbidities on Serum IgG Levels and Exacerbation Risk in Chronic Obstructive Pulmonary Disease Open
View article: Effect of the number of induction chemotherapy cycles on the efficacy of first-line atezolizumab combined with chemotherapy in extensive-stage small cell lung cancer
Effect of the number of induction chemotherapy cycles on the efficacy of first-line atezolizumab combined with chemotherapy in extensive-stage small cell lung cancer Open
Receiving ≥6 cycles of induction chemotherapy significantly prolonged the median PFS and median OS of patients, highlighting its crucial factor influencing the efficacy of first-line atezolizumab combined with chemotherapy in patients with…
View article: Endoscopic Features of Early Autoimmune Gastritis: Insights From a Case Study in a Young Male Patient
Endoscopic Features of Early Autoimmune Gastritis: Insights From a Case Study in a Young Male Patient Open
Autoimmune gastritis, traditionally called type A gastritis, is characterized by cor-pus-predominant atrophic gastritis caused by autoimmune mechanisms. Most cases are diagnosed in middle-aged or elderly individuals, as complications such …
View article: Providencia rettgeri and Group G Streptococcus in Anorexia Nervosa-Related Empyema: A Case Report
Providencia rettgeri and Group G Streptococcus in Anorexia Nervosa-Related Empyema: A Case Report Open
BACKGROUND Anorexia nervosa, predominantly affecting young females, significantly compromises the immune system, rendering patients vulnerable to infections and contributing to a notably high mortality rate. The complexities involved in ma…
View article: Endobronchial tuberculosis mimicking malignancy: Lessons from a case report
Endobronchial tuberculosis mimicking malignancy: Lessons from a case report Open
View article: Radiological and Pathological Analysis of Pembrolizumab-Associated Lung Lesions: Diagnostic Challenges and Management
Radiological and Pathological Analysis of Pembrolizumab-Associated Lung Lesions: Diagnostic Challenges and Management Open
BACKGROUND Pembrolizumab, a programmed cell-death protein-1 (PD-1)-targeting antibody, extends survival in cancer patients but may cause lung injury as a side effect. This immunotherapy enhances the immune system's ability to recognize and…
View article: Construction and validation of a prognostic model based on oxidative stress-related genes in non-small cell lung cancer (NSCLC): predicting patient outcomes and therapy responses
Construction and validation of a prognostic model based on oxidative stress-related genes in non-small cell lung cancer (NSCLC): predicting patient outcomes and therapy responses Open
This study successfully developed a robust model for predicting patient prognosis in NSCLC, highlighting the critical prognostic value of OS-genes. These findings hold significant potential to refine treatment strategies, and enhance survi…
View article: Transforming Lung Cancer Management: A Promising Case Study of Immune Checkpoint Inhibitor Success Following a Multidisciplinary Approach
Transforming Lung Cancer Management: A Promising Case Study of Immune Checkpoint Inhibitor Success Following a Multidisciplinary Approach Open
A 54-year-old female patient diagnosed with Stage IIIb squamous cell carcinoma (cT2aN3M0) initially received chemoradiotherapy. Two years after initial treatment, cancer relapse led to the administration of nivolumab, which was halted due …
View article: Inhibiting Invariant Natural Killer T-Cell Activation: A Promising Strategy against Pulmonary Fibrosis
Inhibiting Invariant Natural Killer T-Cell Activation: A Promising Strategy against Pulmonary Fibrosis Open
View article: Bleomycin-Induced Pulmonary Fibrosis in Transgenic Mice Carrying the Human MUC5B rs35705950 Variant
Bleomycin-Induced Pulmonary Fibrosis in Transgenic Mice Carrying the Human MUC5B rs35705950 Variant Open
Idiopathic pulmonary fibrosis (IPF) is a progressive, often fatal lung disease characterized by tissue scarring and declining lung function. The MUC5B promoter polymorphism rs35705950, a significant genetic predisposition for IPF, paradoxi…
View article: Lymphocyte activation markers predict the therapeutic response to immune checkpoint inhibitors: A case–control study
Lymphocyte activation markers predict the therapeutic response to immune checkpoint inhibitors: A case–control study Open
Background Reports on changes in circulating immune cells induced by immune checkpoint inhibitors (ICIs) and their association with therapeutic responses are limited. This study aimed to analyze the interaction between ICIs and circulating…
View article: The Protective Role of KANK1 in Podocyte Injury
The Protective Role of KANK1 in Podocyte Injury Open
Approximately 30% of steroid-resistant nephrotic syndromes are attributed to monogenic disorders that involve 27 genes. Mutations in KANK family members have also been linked to nephrotic syndrome; however, the precise mechanism remains el…
View article: The Protective Role of KANK1 in Podocyte Injury
The Protective Role of KANK1 in Podocyte Injury Open
Approximately 30% of steroid-resistant nephrotic syndromes are attributed to monogenic disorders that involve 27 genes. Mutations in KANK family members have also been linked to nephrotic syndrome; however, the precise mechanism remains el…
View article: Impact of immune‐related adverse events on survival outcomes in extensive‐stage small cell lung cancer patients treated with immune checkpoint inhibitors
Impact of immune‐related adverse events on survival outcomes in extensive‐stage small cell lung cancer patients treated with immune checkpoint inhibitors Open
Background Immune checkpoint inhibitors have recently become the standard of care in the first‐line treatment of extensive‐stage small cell lung cancer. Although immune‐related adverse events have been reported to influence prognosis in no…
View article: Cell Death in Acute Organ Injury and Fibrosis
Cell Death in Acute Organ Injury and Fibrosis Open
Tissue fibrosis is characterized by the excessive accumulation of extracellular matrix in various organs, including the lungs, liver, skin, kidneys, pancreas, and heart, ultimately leading to organ failure [...]
View article: A case of rapidly progressive insulin-dependent diabetes mellitus without islet autoantibodies developed over two years after the first dose of nivolumab
A case of rapidly progressive insulin-dependent diabetes mellitus without islet autoantibodies developed over two years after the first dose of nivolumab Open
View article: Hangeshashinto-Associated Mesenteric Phlebosclerosis and Highly Atypical Adenoma Requiring Laparoscopic Right Hemicolectomy
Hangeshashinto-Associated Mesenteric Phlebosclerosis and Highly Atypical Adenoma Requiring Laparoscopic Right Hemicolectomy Open
Mesenteric phlebosclerosis is a rare ischemic colonic disorder caused by impaired venous drainage. Its prevalence is higher in East Asia, where herbal medicine is widely used. Treatment remains controversial. A 76-year-old woman who had ta…
View article: Role of microbiota-derived corisin in coagulation activation during SARS-CoV-2 infection
Role of microbiota-derived corisin in coagulation activation during SARS-CoV-2 infection Open
The microbiota-derived corisin is significantly increased and correlated with activation of the coagulation system during SARS-CoV-2 infection, and corisin may directly increase the procoagulant activity in epithelial, endothelial, and mon…
View article: Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis
Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis Open
"Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Adenine Nucleotide Translocases and Cellular Senescence in Idiopathic Pulmonary Fibrosis
Adenine Nucleotide Translocases and Cellular Senescence in Idiopathic Pulmonary Fibrosis Open
"Adenine Nucleotide Translocases and Cellular Senescence in Idiopathic Pulmonary Fibrosis." American Journal of Respiratory Cell and Molecular Biology, 0(ja), pp.
View article: Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis
Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis Open
Background Acute cholangitis is a severe, life-threatening infection of the biliary system that requires early diagnosis and treatment. The Tokyo Guidelines recommend a combination of clinical, laboratory, and imaging findings for diagnosi…
View article: EP12.01-34 Autopsy and Next Generation Sequencing Report of First-Line Treatment with Osimertinib for EGFR-Mutated Squamous Cell Carcinoma of the Lung
EP12.01-34 Autopsy and Next Generation Sequencing Report of First-Line Treatment with Osimertinib for EGFR-Mutated Squamous Cell Carcinoma of the Lung Open
View article: Bilateral Nephrectomy for Resistant Hypertension and Secondary Aldosteronism in a Hemodialysis Patient: A Case Report
Bilateral Nephrectomy for Resistant Hypertension and Secondary Aldosteronism in a Hemodialysis Patient: A Case Report Open
A 42-year-old Japanese woman with end-stage renal failure due to hypertension presented with a systolic blood pressure of 160-200 mmHg despite treatment with 4 different antihypertensive agents. The plasma aldosterone concentration (PAC) a…